Contrast-induced encephalopathy (CIE) is a rare complication of cerebral angiography. Clinical effects of iodinated-agents neurotoxicity include encephalopathy, convulsions, cortical blindness, and/or focal neurologic deficits [
1]. Imaging is essential in the diagnosis by showing typical computed tomography (CT)/magnetic resonance imaging (MRI) findings that are described in association with CIE and excluding thromboembolic and/or hemorrhagic complications [
1,
2]. Here, we report two cases of probable CIE which highlights that contrast-induced neurotoxicity may not always present with the typical clinical and radiological findings and we discuss the pathophysiological overlap with posterior reversible encephalopathy syndrome (PRES). …