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01.12.2014 | Case Report

Transient leukemia in a newborn without Down syndrome: case report and review of the literature

verfasst von: Laurence Rozen, Sophie Huybrechts, Laurence Dedeken, Catherine Heijmans, Barbara Dessars, Pierre Heimann, Frédéric Lambert, Denis F. Noubouossie, Alina Ferster, Anne Demulder

Erschienen in: European Journal of Pediatrics | Ausgabe 12/2014

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Abstract

Transient neonatal leukemia occurs almost exclusively in Down syndrome babies. We report here the unusual case of a newborn without Down syndrome who presented neonatal transient leukemia and who achieved spontaneously complete remission. Trisomy 21 and GATA1 mutation were both present in leukemic cells. While close follow-up is advised since true leukemia may develop later, the patient is still in remission for 2.5 years. We performed a literature review of 15 other similar cases. Conclusion: Our case of transient leukemia without Down syndrome and the literature review highlight the important role of trisomy 21 and GATA1 mutation in the development of transient neonatal leukemia.

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Titel: Transient leukemia in a newborn without Down syndrome: case report and review of the literature
verfasst von: Laurence Rozen
Sophie Huybrechts
Laurence Dedeken
Catherine Heijmans
Barbara Dessars
Pierre Heimann
Frédéric Lambert
Denis F. Noubouossie
Alina Ferster
Anne Demulder
Publikationsdatum: 01.12.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Pediatrics / Ausgabe 12/2014
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-013-2163-8

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Transient leukemia in a newborn without Down syndrome: case report and review of the literature

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