Transitions of multifocal electroretinography in patients with age-related macular degeneration after combination therapy with photodynamic therapy and intravitreal bevacizumab

To evaluate by multifocal electroretinograms (mfERG) the macular function before and after combined treatment with photodynamic therapy (PDT) and intravitreal bevacizumab in eyes suffering from choroidal neovascularization (CNV) due to age-related macular degeneration (AMD). 15 eyes of 15 patients with subfoveal CNV were studied before and after the combined treatment. The post-treatment follow-up was 6 months. MfERG recordings were performed in each patient before and 1, 3, and 6 months after the treatment. The mean N1 response amplitudes tended to increase after the treatment, and ring 2 response amplitude was significantly increased at 3 and 6 months compared to baseline (P = 0.033, 0.005, respectively). For mean P1 response amplitudes, there was a significant increase in retinal response amplitudes in ring 1–3 at 6 months (P = 0.036, 0.013, 0.008, respectively). No statistically significant difference in both mean N1 and P1 latency was observed for any ring over the course of treatment. PDT combined with intravitreal bevacizumab can increase the response amplitudes of mfERG in neovascular AMD patients.