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Erschienen in: HNO 8/2021

14.05.2021 | Riechstörungen | Übersichten

Zukunftsweisende Therapieansätze bei Riechstörungen: elektrische Stimulation, Stammzelltherapie und Transplantation von Riechepithel – eine Übersicht

verfasst von: Dr. med. P. Dörig, N. Gunder, M. Witt, A. Welge-Lüssen, T. Hummel

Erschienen in: HNO | Ausgabe 8/2021

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Zusammenfassung

Passagere oder permanente Riechstörungen können verschiedene Ursachen haben. Ganz aktuell berichtet eine Vielzahl von Patienten im Rahmen von COVID-19-Infektionen über ein fehlendes oder vermindertes Riechvermögen. In der Vergangenheit wurden vielfältige Therapieoptionen untersucht, diese variieren vom Riechtraining über Akupunktur und medikamentöse Therapien bis hin zur transkraniellen Magnetstimulation oder, z. B. bei ausgeprägten qualitativen Riechstörungen, der chirurgischen Resektion der Riechschleimhaut. Die Entwicklung einer bioelektrischen Nase, z. B. in Verbindung mit direkter elektrischer Stimulation des Bulbus olfactorius, oder die Transplantation von Riechschleimhaut oder von Stammzellen stellen Behandlungsmöglichkeiten der Zukunft dar. Die Grundlagen für diese Entwicklungen sowie der Stand des Wissens werden in der vorliegenden Arbeit erläutert.
Literatur
1.
Zurück zum Zitat Andy OJ (1967) The amygdala and hippocampus in olfactory aura. Electroencephalogr Clin Neurophysiol 23:292PubMed Andy OJ (1967) The amygdala and hippocampus in olfactory aura. Electroencephalogr Clin Neurophysiol 23:292PubMed
3.
Zurück zum Zitat Aronsohn E (1886) Experimentelle Untersuchungen zur Physiologie des Geruches. In: Archiv für Anatomie und Physiologie, S 321 Aronsohn E (1886) Experimentelle Untersuchungen zur Physiologie des Geruches. In: Archiv für Anatomie und Physiologie, S 321
4.
Zurück zum Zitat Balassa K, Danby R, Rocha V (2019) Haematopoietic stem cell transplants: principles and indications. Br J Hosp Med (Lond) 80:33–39CrossRef Balassa K, Danby R, Rocha V (2019) Haematopoietic stem cell transplants: principles and indications. Br J Hosp Med (Lond) 80:33–39CrossRef
5.
Zurück zum Zitat Berard N, Landis BN, Legrand L et al (2020) Electrical stimulation of the medial orbitofrontal cortex in humans elicits pleasant olfactory perceptions. Epilepsy Behav 114:107559PubMedCrossRef Berard N, Landis BN, Legrand L et al (2020) Electrical stimulation of the medial orbitofrontal cortex in humans elicits pleasant olfactory perceptions. Epilepsy Behav 114:107559PubMedCrossRef
6.
Zurück zum Zitat Besser G, Liu DT, Renner B et al (2019) Olfactory implant: demand for a future treatment option in patients with olfactory dysfunction. Laryngoscope 129:312–316PubMedCrossRef Besser G, Liu DT, Renner B et al (2019) Olfactory implant: demand for a future treatment option in patients with olfactory dysfunction. Laryngoscope 129:312–316PubMedCrossRef
7.
Zurück zum Zitat Bocksberger S, Wagner W, Hummel T et al (2020) Temporary hyposmia in COVID-19 patients. HNO 68:440–443PubMedCrossRef Bocksberger S, Wagner W, Hummel T et al (2020) Temporary hyposmia in COVID-19 patients. HNO 68:440–443PubMedCrossRef
8.
Zurück zum Zitat Bramerson A, Johansson L, Ek L et al (2004) Prevalence of olfactory dysfunction: the skovde population-based study. Laryngoscope 114:733–737PubMedCrossRef Bramerson A, Johansson L, Ek L et al (2004) Prevalence of olfactory dysfunction: the skovde population-based study. Laryngoscope 114:733–737PubMedCrossRef
9.
Zurück zum Zitat Buck LB (2000) Smell and taste: the chemical senses. In: Kandel ER, Schwartz JH, Jessell TM (Hrsg) Principles of neural science. McGraw-Hill, New York, S 625–652 Buck LB (2000) Smell and taste: the chemical senses. In: Kandel ER, Schwartz JH, Jessell TM (Hrsg) Principles of neural science. McGraw-Hill, New York, S 625–652
10.
Zurück zum Zitat Buschhuter D, Smitka M, Puschmann S et al (2008) Correlation between olfactory bulb volume and olfactory function. Neuroimage 42:498–502PubMedCrossRef Buschhuter D, Smitka M, Puschmann S et al (2008) Correlation between olfactory bulb volume and olfactory function. Neuroimage 42:498–502PubMedCrossRef
11.
Zurück zum Zitat Bushdid C, Magnasco MO, Vosshall LB et al (2014) Humans can discriminate more than 1 trillion olfactory stimuli. Science 343:1370–1372PubMedPubMedCentralCrossRef Bushdid C, Magnasco MO, Vosshall LB et al (2014) Humans can discriminate more than 1 trillion olfactory stimuli. Science 343:1370–1372PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Child KM, Herrick DB, Schwob JE et al (2018) The neuroregenerative capacity of olfactory stem cells is not limitless: implications for aging. J Neurosci 38:6806–6824PubMedPubMedCentralCrossRef Child KM, Herrick DB, Schwob JE et al (2018) The neuroregenerative capacity of olfactory stem cells is not limitless: implications for aging. J Neurosci 38:6806–6824PubMedPubMedCentralCrossRef
14.
Zurück zum Zitat Coelho DH, Costanzo RM (2016) Spatial mapping in the rat olfactory bulb by odor and direct electrical stimulation. Otolaryngol Head Neck Surg 155:526–532PubMedCrossRef Coelho DH, Costanzo RM (2016) Spatial mapping in the rat olfactory bulb by odor and direct electrical stimulation. Otolaryngol Head Neck Surg 155:526–532PubMedCrossRef
15.
Zurück zum Zitat Coleman JH, Lin B, Louie JD et al (2019) Spatial determination of neuronal diversification in the olfactory epithelium. J Neurosci 39:814–832PubMedPubMedCentralCrossRef Coleman JH, Lin B, Louie JD et al (2019) Spatial determination of neuronal diversification in the olfactory epithelium. J Neurosci 39:814–832PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Costanzo RM, Yagi S (2011) Olfactory epithelial transplantation: possible mechanism for restoration of smell. Curr Opin Otolaryngol Head Neck Surg 19:54–57PubMedPubMedCentralCrossRef Costanzo RM, Yagi S (2011) Olfactory epithelial transplantation: possible mechanism for restoration of smell. Curr Opin Otolaryngol Head Neck Surg 19:54–57PubMedPubMedCentralCrossRef
17.
Zurück zum Zitat Croy I, Nordin S, Hummel T (2014) Olfactory disorders and quality of life—an updated review. Chem Senses 39:185–194PubMedCrossRef Croy I, Nordin S, Hummel T (2014) Olfactory disorders and quality of life—an updated review. Chem Senses 39:185–194PubMedCrossRef
18.
Zurück zum Zitat Dai Q, Pang Z, Yu H (2016) Recovery of olfactory function in postviral olfactory dysfunction patients after acupuncture treatment. Evid Based Complement Alternat Med 2016:4986034PubMedPubMedCentral Dai Q, Pang Z, Yu H (2016) Recovery of olfactory function in postviral olfactory dysfunction patients after acupuncture treatment. Evid Based Complement Alternat Med 2016:4986034PubMedPubMedCentral
19.
Zurück zum Zitat Damm M, Pikart LK, Reimann H et al (2014) Olfactory training is helpful in postinfectious olfactory loss: a randomized, controlled, multicenter study. Laryngoscope 124:826–831PubMedCrossRef Damm M, Pikart LK, Reimann H et al (2014) Olfactory training is helpful in postinfectious olfactory loss: a randomized, controlled, multicenter study. Laryngoscope 124:826–831PubMedCrossRef
20.
Zurück zum Zitat Damm M, Schmitl L, Muller CA et al (2019) Diagnostics and treatment of olfactory dysfunction. HNO 67:274–281PubMedCrossRef Damm M, Schmitl L, Muller CA et al (2019) Diagnostics and treatment of olfactory dysfunction. HNO 67:274–281PubMedCrossRef
21.
Zurück zum Zitat Diaz D, Lepousez G, Gheusi G et al (2012) Bone marrow cell transplantation restores olfaction in the degenerated olfactory bulb. J Neurosci 32:9053–9058PubMedPubMedCentralCrossRef Diaz D, Lepousez G, Gheusi G et al (2012) Bone marrow cell transplantation restores olfaction in the degenerated olfactory bulb. J Neurosci 32:9053–9058PubMedPubMedCentralCrossRef
22.
Zurück zum Zitat Dong Q, Du L, Zhuang L et al (2013) A novel bioelectronic nose based on brain-machine interface using implanted electrode recording in vivo in olfactory bulb. Biosens Bioelectron 49:263–269PubMedCrossRef Dong Q, Du L, Zhuang L et al (2013) A novel bioelectronic nose based on brain-machine interface using implanted electrode recording in vivo in olfactory bulb. Biosens Bioelectron 49:263–269PubMedCrossRef
23.
Zurück zum Zitat Durante MA, Kurtenbach S, Sargi ZB et al (2020) Single-cell analysis of olfactory neurogenesis and differentiation in adult humans. Nat Neurosci 23:323–326PubMedPubMedCentralCrossRef Durante MA, Kurtenbach S, Sargi ZB et al (2020) Single-cell analysis of olfactory neurogenesis and differentiation in adult humans. Nat Neurosci 23:323–326PubMedPubMedCentralCrossRef
24.
25.
Zurück zum Zitat Graziadei PP, Monti Graziadei AG (1983) Regeneration in the olfactory system of vertebrates. Am J Otolaryngol 4:228–233PubMedCrossRef Graziadei PP, Monti Graziadei AG (1983) Regeneration in the olfactory system of vertebrates. Am J Otolaryngol 4:228–233PubMedCrossRef
26.
Zurück zum Zitat Gudziol V, Buschhuter D, Abolmaali N et al (2009) Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis—a longitudinal study. Brain 132:3096–3101PubMedCrossRef Gudziol V, Buschhuter D, Abolmaali N et al (2009) Increasing olfactory bulb volume due to treatment of chronic rhinosinusitis—a longitudinal study. Brain 132:3096–3101PubMedCrossRef
27.
Zurück zum Zitat Hatzinger M, Stastny M, Grutzmacher P et al (2016) The history of kidney transplantation. Urologe A 55:1353–1359PubMedCrossRef Hatzinger M, Stastny M, Grutzmacher P et al (2016) The history of kidney transplantation. Urologe A 55:1353–1359PubMedCrossRef
28.
Zurück zum Zitat Henkin RI, Potolicchio SJ Jr., Levy LM (2011) Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation. Am J Otolaryngol 32:38–46PubMedCrossRef Henkin RI, Potolicchio SJ Jr., Levy LM (2011) Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation. Am J Otolaryngol 32:38–46PubMedCrossRef
29.
Zurück zum Zitat Holbrook EH, Dinardo LJ, Costanzo RM (2001) Olfactory epithelium grafts in the cerebral cortex: an immunohistochemical analysis. Laryngoscope 111:1964–1969PubMedPubMedCentralCrossRef Holbrook EH, Dinardo LJ, Costanzo RM (2001) Olfactory epithelium grafts in the cerebral cortex: an immunohistochemical analysis. Laryngoscope 111:1964–1969PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Holbrook EH, Puram SV, See RB et al (2019) Induction of smell through transethmoid electrical stimulation of the olfactory bulb. Int Forum Allergy Rhinol 9:158–164PubMedCrossRef Holbrook EH, Puram SV, See RB et al (2019) Induction of smell through transethmoid electrical stimulation of the olfactory bulb. Int Forum Allergy Rhinol 9:158–164PubMedCrossRef
31.
Zurück zum Zitat Hummel T, Heilmann S, Huttenbriuk KB (2002) Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract. Laryngoscope 112:2076–2080PubMedCrossRef Hummel T, Heilmann S, Huttenbriuk KB (2002) Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract. Laryngoscope 112:2076–2080PubMedCrossRef
33.
Zurück zum Zitat Ishimaru T, Shimada T, Sakumoto M et al (1997) Olfactory evoked potential produced by electrical stimulation of the human olfactory mucosa. Chem Senses 22:77–81PubMedCrossRef Ishimaru T, Shimada T, Sakumoto M et al (1997) Olfactory evoked potential produced by electrical stimulation of the human olfactory mucosa. Chem Senses 22:77–81PubMedCrossRef
35.
Zurück zum Zitat Kumar G, Juhasz C, Sood S et al (2012) Olfactory hallucinations elicited by electrical stimulation via subdural electrodes: effects of direct stimulation of olfactory bulb and tract. Epilepsy Behav 24:264–268PubMedPubMedCentralCrossRef Kumar G, Juhasz C, Sood S et al (2012) Olfactory hallucinations elicited by electrical stimulation via subdural electrodes: effects of direct stimulation of olfactory bulb and tract. Epilepsy Behav 24:264–268PubMedPubMedCentralCrossRef
36.
Zurück zum Zitat Kurtenbach S, Goss GM, Goncalves S et al (2019) Cell-based therapy restores olfactory function in an inducible model of hyposmia. Stem Cell Reports 12:1354–1365PubMedPubMedCentralCrossRef Kurtenbach S, Goss GM, Goncalves S et al (2019) Cell-based therapy restores olfactory function in an inducible model of hyposmia. Stem Cell Reports 12:1354–1365PubMedPubMedCentralCrossRef
37.
Zurück zum Zitat Landis BN, Konnerth CG, Hummel T (2004) A study on the frequency of olfactory dysfunction. Laryngoscope 114:1764–1769PubMedCrossRef Landis BN, Konnerth CG, Hummel T (2004) A study on the frequency of olfactory dysfunction. Laryngoscope 114:1764–1769PubMedCrossRef
38.
Zurück zum Zitat Leopold DA, Loehrl TA, Schwob JE (2002) Long-term follow-up of surgically treated phantosmia. Arch Otolaryngol Head Neck Surg 128:642–647PubMedCrossRef Leopold DA, Loehrl TA, Schwob JE (2002) Long-term follow-up of surgically treated phantosmia. Arch Otolaryngol Head Neck Surg 128:642–647PubMedCrossRef
39.
Zurück zum Zitat Malnic B, Hirono J, Sato T et al (1999) Combinatorial receptor codes for odors. Cell 96:713–723PubMedCrossRef Malnic B, Hirono J, Sato T et al (1999) Combinatorial receptor codes for odors. Cell 96:713–723PubMedCrossRef
40.
Zurück zum Zitat Mazzola L, Royet JP, Catenoix H et al (2017) Gustatory and olfactory responses to stimulation of the human insula. Ann Neurol 82:360–370PubMedCrossRef Mazzola L, Royet JP, Catenoix H et al (2017) Gustatory and olfactory responses to stimulation of the human insula. Ann Neurol 82:360–370PubMedCrossRef
41.
Zurück zum Zitat Meisami E (1976) Effects of olfactory deprivation on postnatal growth of the rat olfactory bulb utilizing a new method for production of neonatal unilateral anosmia. Brain Res 107:437–444PubMedCrossRef Meisami E (1976) Effects of olfactory deprivation on postnatal growth of the rat olfactory bulb utilizing a new method for production of neonatal unilateral anosmia. Brain Res 107:437–444PubMedCrossRef
42.
Zurück zum Zitat Mombaerts P (1999) Seven-transmembrane proteins as odorant and chemosensory receptors. Science 286:707–711PubMedCrossRef Mombaerts P (1999) Seven-transmembrane proteins as odorant and chemosensory receptors. Science 286:707–711PubMedCrossRef
43.
Zurück zum Zitat Morrison EE, Graziadei PP (1983) Transplants of olfactory mucosa in the rat brain I. A light microscopic study of transplant organization. Brain Res 279:241–245PubMedCrossRef Morrison EE, Graziadei PP (1983) Transplants of olfactory mucosa in the rat brain I. A light microscopic study of transplant organization. Brain Res 279:241–245PubMedCrossRef
44.
Zurück zum Zitat Morrissey DK, Pratap U, Brown C et al (2016) The role of surgery in the management of phantosmia. Laryngoscope 126:575–578PubMedCrossRef Morrissey DK, Pratap U, Brown C et al (2016) The role of surgery in the management of phantosmia. Laryngoscope 126:575–578PubMedCrossRef
45.
Zurück zum Zitat Mudry A, Mills M (2013) The early history of the cochlear implant: a retrospective. JAMA Otolaryngol Head Neck Surg 139:446–453PubMedCrossRef Mudry A, Mills M (2013) The early history of the cochlear implant: a retrospective. JAMA Otolaryngol Head Neck Surg 139:446–453PubMedCrossRef
46.
Zurück zum Zitat Mueller A, Rodewald A, Reden J et al (2005) Reduced olfactory bulb volume in post-traumatic and post-infectious olfactory dysfunction. NeuroReport 16:475–478PubMedCrossRef Mueller A, Rodewald A, Reden J et al (2005) Reduced olfactory bulb volume in post-traumatic and post-infectious olfactory dysfunction. NeuroReport 16:475–478PubMedCrossRef
47.
Zurück zum Zitat Murrell W, Bushell GR, Livesey J et al (1996) Neurogenesis in adult human. NeuroReport 7:1189–1194PubMedCrossRef Murrell W, Bushell GR, Livesey J et al (1996) Neurogenesis in adult human. NeuroReport 7:1189–1194PubMedCrossRef
48.
Zurück zum Zitat Nashold BS, Wilson WP (1970) Olfactory hallucinations evoked from stimulation of human thalamus. Confin Neurol 32:298–306PubMedCrossRef Nashold BS, Wilson WP (1970) Olfactory hallucinations evoked from stimulation of human thalamus. Confin Neurol 32:298–306PubMedCrossRef
49.
Zurück zum Zitat Ochi N, Doi K, Uranagase M et al (2010) Bone marrow stem cell transplantation to olfactory epithelium. Ann Otol Rhinol Laryngol 119:535–540PubMedCrossRef Ochi N, Doi K, Uranagase M et al (2010) Bone marrow stem cell transplantation to olfactory epithelium. Ann Otol Rhinol Laryngol 119:535–540PubMedCrossRef
50.
51.
Zurück zum Zitat Ottoson D (1959) Olfactory bulb potentials induced by electrical stimulation of the nasal mucosa in the frog. Acta Physiol Scand 47:160–172PubMedCrossRef Ottoson D (1959) Olfactory bulb potentials induced by electrical stimulation of the nasal mucosa in the frog. Acta Physiol Scand 47:160–172PubMedCrossRef
52.
Zurück zum Zitat Penfield W, Jasper H (1954) Epilepsy and the functional anatomy of the human brain. Little Brown, BostonCrossRef Penfield W, Jasper H (1954) Epilepsy and the functional anatomy of the human brain. Little Brown, BostonCrossRef
53.
Zurück zum Zitat Peterson NR, Pisoni DB, Miyamoto RT (2010) Cochlear implants and spoken language processing abilities: review and assessment of the literature. Restor Neurol Neurosci 28:237–250PubMedPubMedCentral Peterson NR, Pisoni DB, Miyamoto RT (2010) Cochlear implants and spoken language processing abilities: review and assessment of the literature. Restor Neurol Neurosci 28:237–250PubMedPubMedCentral
54.
Zurück zum Zitat Philpott CM, Boak D (2014) The impact of olfactory disorders in the United Kingdom. Chem Senses 39:711–718PubMedCrossRef Philpott CM, Boak D (2014) The impact of olfactory disorders in the United Kingdom. Chem Senses 39:711–718PubMedCrossRef
55.
Zurück zum Zitat Qiao XF, Wang GP, Li X et al (2019) Analysis of the clinical effect of olfactory training on olfactory dysfunction after upper respiratory tract infection. Acta Otolaryngol 139:643–646PubMedCrossRef Qiao XF, Wang GP, Li X et al (2019) Analysis of the clinical effect of olfactory training on olfactory dysfunction after upper respiratory tract infection. Acta Otolaryngol 139:643–646PubMedCrossRef
56.
Zurück zum Zitat Quint C, Temmel AF, Hummel T et al (2002) The quinoxaline derivative caroverine in the treatment of sensorineural smell disorders: a proof-of-concept study. Acta Otolaryngol 122:877–881PubMedCrossRef Quint C, Temmel AF, Hummel T et al (2002) The quinoxaline derivative caroverine in the treatment of sensorineural smell disorders: a proof-of-concept study. Acta Otolaryngol 122:877–881PubMedCrossRef
57.
Zurück zum Zitat Rachitskaya AV, Yuan A (2016) Argus II retinal prosthesis system: an update. Ophthalmic Genet 37:260–266PubMedCrossRef Rachitskaya AV, Yuan A (2016) Argus II retinal prosthesis system: an update. Ophthalmic Genet 37:260–266PubMedCrossRef
58.
Zurück zum Zitat Ressler KJ, Sullivan SL, Buck LB (1994) Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell 79:1245–1255PubMedCrossRef Ressler KJ, Sullivan SL, Buck LB (1994) Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb. Cell 79:1245–1255PubMedCrossRef
59.
Zurück zum Zitat Rombaux P, Potier H, Markessis E et al (2010) Olfactory bulb volume and depth of olfactory sulcus in patients with idiopathic olfactory loss. Eur Arch Otorhinolaryngol 267:1551–1556PubMedCrossRef Rombaux P, Potier H, Markessis E et al (2010) Olfactory bulb volume and depth of olfactory sulcus in patients with idiopathic olfactory loss. Eur Arch Otorhinolaryngol 267:1551–1556PubMedCrossRef
61.
Zurück zum Zitat Schriever VA, Merkonidis C, Gupta N et al (2012) Treatment of smell loss with systemic methylprednisolone. Rhinology 50:284–289PubMedCrossRef Schriever VA, Merkonidis C, Gupta N et al (2012) Treatment of smell loss with systemic methylprednisolone. Rhinology 50:284–289PubMedCrossRef
62.
Zurück zum Zitat Schwob JE (2002) Neural regeneration and the peripheral olfactory system. Anat Rec 269:33–49PubMedCrossRef Schwob JE (2002) Neural regeneration and the peripheral olfactory system. Anat Rec 269:33–49PubMedCrossRef
63.
Zurück zum Zitat Serizawa S, Ishii T, Nakatani H et al (2000) Mutually exclusive expression of odorant receptor transgenes. Nat Neurosci 3:687–693PubMedCrossRef Serizawa S, Ishii T, Nakatani H et al (2000) Mutually exclusive expression of odorant receptor transgenes. Nat Neurosci 3:687–693PubMedCrossRef
64.
Zurück zum Zitat Sharma A, Kumar R, Aier I et al (2019) Sense of smell: structural, functional, mechanistic advancements and challenges in human olfactory research. Curr Neuropharmacol 17:891–911PubMedPubMedCentralCrossRef Sharma A, Kumar R, Aier I et al (2019) Sense of smell: structural, functional, mechanistic advancements and challenges in human olfactory research. Curr Neuropharmacol 17:891–911PubMedPubMedCentralCrossRef
65.
Zurück zum Zitat Sorokowska A, Drechsler E, Karwowski M et al (2017) Effects of olfactory training: a meta-analysis. Rhinology 55:17–26PubMedCrossRef Sorokowska A, Drechsler E, Karwowski M et al (2017) Effects of olfactory training: a meta-analysis. Rhinology 55:17–26PubMedCrossRef
66.
Zurück zum Zitat Straschill M, Stahl H, Gorkisch K (1983) Effects of electrical stimulation of the human olfactory mucosa. Appl Neurophysiol 46:286–289PubMed Straschill M, Stahl H, Gorkisch K (1983) Effects of electrical stimulation of the human olfactory mucosa. Appl Neurophysiol 46:286–289PubMed
67.
Zurück zum Zitat Tsujigiwa H, Nishizaki K, Teshima T et al (2005) The engraftment of transplanted bone marrow-derived cells into the olfactory epithelium. Brain Res 1052:10–15PubMedCrossRef Tsujigiwa H, Nishizaki K, Teshima T et al (2005) The engraftment of transplanted bone marrow-derived cells into the olfactory epithelium. Brain Res 1052:10–15PubMedCrossRef
68.
Zurück zum Zitat Uchida N, Takahashi YK, Tanifuji M et al (2000) Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features. Nat Neurosci 3:1035–1043PubMedCrossRef Uchida N, Takahashi YK, Tanifuji M et al (2000) Odor maps in the mammalian olfactory bulb: domain organization and odorant structural features. Nat Neurosci 3:1035–1043PubMedCrossRef
69.
Zurück zum Zitat Uziel A (1973) Stimulation of human olfactory neuro-epithelium by long-term continuous electrical currents. J Physiol (Paris) 66:409–422 Uziel A (1973) Stimulation of human olfactory neuro-epithelium by long-term continuous electrical currents. J Physiol (Paris) 66:409–422
70.
Zurück zum Zitat Van Der Linden CJ, Gupta P, Bhuiya AI et al (2020) Olfactory stimulation regulates the birth of neurons that express specific odorant receptors. Cell Rep 33:108210PubMedPubMedCentralCrossRef Van Der Linden CJ, Gupta P, Bhuiya AI et al (2020) Olfactory stimulation regulates the birth of neurons that express specific odorant receptors. Cell Rep 33:108210PubMedPubMedCentralCrossRef
71.
Zurück zum Zitat Vassar R, Chao SK, Sitcheran R et al (1994) Topographic organization of sensory projections to the olfactory bulb. Cell 79:981–991PubMedCrossRef Vassar R, Chao SK, Sitcheran R et al (1994) Topographic organization of sensory projections to the olfactory bulb. Cell 79:981–991PubMedCrossRef
72.
Zurück zum Zitat Vassar R, Ngai J, Axel R (1993) Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell 74:309–318PubMedCrossRef Vassar R, Ngai J, Axel R (1993) Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell 74:309–318PubMedCrossRef
73.
Zurück zum Zitat Vennemann MM, Hummel T, Berger K (2008) The association between smoking and smell and taste impairment in the general population. J Neurol 255:1121–1126PubMedCrossRef Vennemann MM, Hummel T, Berger K (2008) The association between smoking and smell and taste impairment in the general population. J Neurol 255:1121–1126PubMedCrossRef
74.
Zurück zum Zitat Verbeurgt C, Wilkin F, Tarabichi M et al (2014) Profiling of olfactory receptor gene expression in whole human olfactory mucosa. PLoS ONE 9:e96333PubMedPubMedCentralCrossRef Verbeurgt C, Wilkin F, Tarabichi M et al (2014) Profiling of olfactory receptor gene expression in whole human olfactory mucosa. PLoS ONE 9:e96333PubMedPubMedCentralCrossRef
75.
Zurück zum Zitat Weiss T, Shushan S, Ravia A et al (2016) From nose to brain: un-sensed electrical currents applied in the nose alter activity in deep brain structures. Cereb Cortex 26:4180–4191PubMedPubMedCentralCrossRef Weiss T, Shushan S, Ravia A et al (2016) From nose to brain: un-sensed electrical currents applied in the nose alter activity in deep brain structures. Cereb Cortex 26:4180–4191PubMedPubMedCentralCrossRef
76.
Zurück zum Zitat Whitcroft KL, Cuevas M, Haehner A et al (2017) Patterns of olfactory impairment reflect underlying disease etiology. Laryngoscope 127:291–295PubMedCrossRef Whitcroft KL, Cuevas M, Haehner A et al (2017) Patterns of olfactory impairment reflect underlying disease etiology. Laryngoscope 127:291–295PubMedCrossRef
77.
Zurück zum Zitat Witt M (2020) Anatomy and development of the human gustatory and olfactory system. In: Fritzsch B (Hrsg) The senses: a comprehensive reference, 2. Aufl. Elsevier, Amsterdam, S 85–118CrossRef Witt M (2020) Anatomy and development of the human gustatory and olfactory system. In: Fritzsch B (Hrsg) The senses: a comprehensive reference, 2. Aufl. Elsevier, Amsterdam, S 85–118CrossRef
78.
Zurück zum Zitat Witt M, Hansen A (2009) Strukturelle und funktionelle Grundlagen des Riechens. In: Hummel T, Welge-Luessen A (Hrsg) Riech- und Schmeckstörungen. Thieme, Stuttgart, S 11–26 Witt M, Hansen A (2009) Strukturelle und funktionelle Grundlagen des Riechens. In: Hummel T, Welge-Luessen A (Hrsg) Riech- und Schmeckstörungen. Thieme, Stuttgart, S 11–26
79.
Zurück zum Zitat Yagi S, Costanzo RM (2009) Grafting the olfactory epithelium to the olfactory bulb. Am J Rhinol Allergy 23:239–243PubMedCrossRef Yagi S, Costanzo RM (2009) Grafting the olfactory epithelium to the olfactory bulb. Am J Rhinol Allergy 23:239–243PubMedCrossRef
Metadaten
Titel
Zukunftsweisende Therapieansätze bei Riechstörungen: elektrische Stimulation, Stammzelltherapie und Transplantation von Riechepithel – eine Übersicht
verfasst von
Dr. med. P. Dörig
N. Gunder
M. Witt
A. Welge-Lüssen
T. Hummel
Publikationsdatum
14.05.2021
Verlag
Springer Medizin
Erschienen in
HNO / Ausgabe 8/2021
Print ISSN: 0017-6192
Elektronische ISSN: 1433-0458
DOI
https://doi.org/10.1007/s00106-021-01060-x

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