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Intensive Care Medicine

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01.12.2014 | Editorial

Treating HSV and CMV reactivations in critically ill patients who are not immunocompromised: pro

verfasst von: Jean-Marie Forel, Ignacio Martin-Loeches, Charles-Edouard Luyt

Erschienen in: Intensive Care Medicine | Ausgabe 12/2014

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Excerpt

Cytomegalovirus (CMV) and herpes simplex virus-1 (HSV-1) have received increasing attention as potential pathogens in critically ill patients. Both have the ability to develop viral latency, and critically ill patients, especially those with sepsis, can develop an immunosuppressed state that might reactivate the lysogenic part of the viral life cycle [1]. The mechanisms of this immunosuppression which can contribute to viral reactivation include apoptotic depletion of CD4 and CD8 T cells, T cell exhaustion, increased T-regulatory cells, myeloid-derived suppressor cells and impaired natural killer cell function [2, 3]. However, no study has been conducted in order to analyse the impact of antiviral treatment in immunocompetent critically ill patients with HSV or CMV reactivation. …

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Titel: Treating HSV and CMV reactivations in critically ill patients who are not immunocompromised: pro
verfasst von: Jean-Marie Forel
Ignacio Martin-Loeches
Charles-Edouard Luyt
Publikationsdatum: 01.12.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Intensive Care Medicine / Ausgabe 12/2014
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-014-3445-y

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