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Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases 9/2022

01.08.2022 | Brief Report

Treatment duration for central line-associated infection caused by Enterococcus spp.: a retrospective evaluation of a multicenter cohort

verfasst von: Elena Rosselli Del Turco, Zeno Pasquini, Kristian Scolz, Alberto Amedeo, Giacomo Beci, Maddalena Giglia, Linda Bussini, Sulamita Carvalho-Brugger, Laura Gutiérrez, Sara Tedeschi, Mercè Garcia, Simone Ambretti, Juan M. Pericàs, Maddalena Giannella, Pierluigi Viale, Michele Bartoletti

Erschienen in: European Journal of Clinical Microbiology & Infectious Diseases | Ausgabe 9/2022

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Abstract

Objective of this study was to assess the appropriate treatment duration for enterococcal central line-associated bloodstream infections (CLABSIs). This observational, retrospective, multicenter study conducted between 2011 and 2019 enrolled all hospitalized patients with monomicrobial enterococcal CLABSI. Those with infective endocarditis and non-survivors at least 7 days from index blood culture (BC) were excluded. Primary endpoint was 30-day mortality. We enrolled 113 patients, of whom 59% were male, median age was 64 (SD ± 15) and median Charlson’s index score 5 (IQR 3–8). Enterococcus faecalis and Enterococcus faecium were found in 51% and 44% of cases, respectively. Median treatment duration was 11 days (IQR 6–17), and 32% of patients (n = 36) received ≤ 7 days. Characteristics of patients receiving more or less than 7 days of treatment were similar. Central line was removed in 82% (n = 93) of cases within a median of 3 days (1–8). At both uni- and multivariate analysis, duration of antibiotic treatment > 7 days was not associated with 30-day mortality [HR 0.41 (95% CI, 0.13–1.24), p = 0.12] even after adjustment with propensity score [HR 0.47 (95% CI 0.17–1.26), p = 0.13]. A 7-day treatment course appears to be safe in non-complicated enterococcal CLABSIs.
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Metadaten
Titel
Treatment duration for central line-associated infection caused by Enterococcus spp.: a retrospective evaluation of a multicenter cohort
verfasst von
Elena Rosselli Del Turco
Zeno Pasquini
Kristian Scolz
Alberto Amedeo
Giacomo Beci
Maddalena Giglia
Linda Bussini
Sulamita Carvalho-Brugger
Laura Gutiérrez
Sara Tedeschi
Mercè Garcia
Simone Ambretti
Juan M. Pericàs
Maddalena Giannella
Pierluigi Viale
Michele Bartoletti
Publikationsdatum
01.08.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Clinical Microbiology & Infectious Diseases / Ausgabe 9/2022
Print ISSN: 0934-9723
Elektronische ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-022-04481-w

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