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European Journal of Orthopaedic Surgery & Traumatology

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28.10.2017 | General Review • BONE - TRAUMA

Treatment of critical-sized bone defects: clinical and tissue engineering perspectives

verfasst von: Erika Roddy, Malcolm R. DeBaun, Adam Daoud-Gray, Yunzhi P. Yang, Michael J. Gardner

Erschienen in: European Journal of Orthopaedic Surgery & Traumatology | Ausgabe 3/2018

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Abstract

Critical-sized bone defects are defined as those that will not heal spontaneously within a patient’s lifetime. Current treatment options include vascularized bone grafts, distraction osteogenesis, and the induced membrane technique. The induced membrane technique is an increasingly utilized method with favorable results including high rates of union. Tissue engineering holds promise in the treatment of large bone defects due to advancement of stem cell biology, novel biomaterials, and 3D bioprinting. In this review, we provide an overview of the current operative treatment strategies of critical-sized bone defects as well as the current state of tissue engineering for such defects.

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Titel: Treatment of critical-sized bone defects: clinical and tissue engineering perspectives
verfasst von: Erika Roddy
Malcolm R. DeBaun
Adam Daoud-Gray
Yunzhi P. Yang
Michael J. Gardner
Publikationsdatum: 28.10.2017
Verlag: Springer Paris
Erschienen in: European Journal of Orthopaedic Surgery & Traumatology / Ausgabe 3/2018
Print ISSN: 1633-8065
Elektronische ISSN: 1432-1068
DOI: https://doi.org/10.1007/s00590-017-2063-0

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