Treatment of lichen amyloidosis with fractional CO2 laser and topical steroid: a preliminary study of 10 cases

The primary localized cutaneous amyloidosis (PLCA) is characterized by the extracellular deposition of amyloid proteins in previously normal skin without systematic involvement [1]. The main subtypes of PLCA have been identified, which comprises lichen amyloidosis (LA), macular amyloidosis (MA), and nodular amyloidosis (NA). Additionally, the combined appearance of different subtypes will occur [2, 3]. Lichen amyloidosis (LA), the most common form of PLCA, presents with localized or rarely generalized, hyperpigmented macules or papules, which is usually located on the shins, calves, dorsal feet, forearms, or thighs [4, 5] with severe pruritus. And LA is reported to commonly present with MA lesions. Etiopathology and causal factors of LA have not been fully elucidated. And LA is considered to be related to heredity, long-term friction stimulation, EB virus infection, environment, and other factors [6]. …