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Current Colorectal Cancer Reports

Erschienen in:

14.06.2017 | Systemic Therapies in Colorectal Cancer (RD Kim, Section Editor)

Treatment of Refractory Colorectal Cancer: Regorafenib vs. TAS-102

verfasst von: Jae Ho Jeong, Yong Sang Hong, Tae Won Kim

Erschienen in: Current Colorectal Cancer Reports | Ausgabe 4/2017

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Abstract

Purpose of Review

This paper reviews the development, mechanism of action, clinical efficacy, and safety of regorafenib and TAS-102. Through this review, we aimed to help clinicians make an appropriate choice in patients who progressed after standard therapies.

Recent Findings

Regorafenib and TAS-102 have shown superior survival results compared with placebo in refractory metastatic colorectal cancer (mCRC). In the phase III CORRECT study, regorafenib showed significant improvement in overall survival (OS) and progression-free survival (PFS). TAS-102 was associated with OS and PFS benefit as well in the phase III RECOURSE study. However, the toxicity profiles were quite different between the two agents.

Summary

Regorafenib and TAS-102 are approved for the management of refractory mCRC. Optimal treatment sequence for using these two novel agents is not defined yet. Safety profiles and patient’s condition should be considered before using these two agents in clinical settings. Further investigation is needed to identify the predictive biomarkers of both agents. These results will allow patients to benefit more from regorafenib and TAS-102.

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Titel: Treatment of Refractory Colorectal Cancer: Regorafenib vs. TAS-102
verfasst von: Jae Ho Jeong
Yong Sang Hong
Tae Won Kim
Publikationsdatum: 14.06.2017
Verlag: Springer US
Erschienen in: Current Colorectal Cancer Reports / Ausgabe 4/2017
Print ISSN: 1556-3790
Elektronische ISSN: 1556-3804
DOI: https://doi.org/10.1007/s11888-017-0381-6

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Treatment of Refractory Colorectal Cancer: Regorafenib vs. TAS-102

Abstract

Purpose of Review

Recent Findings

Summary

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