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01.12.2011 | Case report | Ausgabe 1/2011 Open Access

Journal of Medical Case Reports 1/2011

Treatment with gefitinib after erlotinib-induced liver injury: a case report

Journal of Medical Case Reports > Ausgabe 1/2011
Katsumi Nakatomi, Yoichi Nakamura, Iida Tetsuya, Shigeru Kohno
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-5-593) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

NK, NY, and IT were the treatment team involved in the case. NY and KS wrote and edited the manuscript. All authors read and approved the final manuscript.



Gefitinib and erlotinib have minor differences in their chemical structures, and thus it remains unclear whether the hepatotoxicity induced by one compound is affected by the other. The case of a patient who developed erlotinib-induced liver injury and was then treated with gefitinib without hepatic toxicity or disease progression is presented.

Case presentation

A 31-year-old Japanese woman, who never smoked and who was diagnosed as having lung adenocarcinoma with carcinomatous meningitis, was treated with erlotinib. She developed erlotinib-induced liver injury after four weeks of treatment. The treatment was stopped right away, but the symptoms of meningitis re-appeared immediately. Gefitinib treatment was started and continued without recurrence of drug-induced liver injury.


Gefitinib appears to be a potential treatment option after erlotinib-induced liver injury.

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