Background
Methods
Data analysis and statistics
Results
Patient’s characteristics
Year | Female | Male |
P
*
| ||
---|---|---|---|---|---|
N (%) | Median age (IQR) | N (%) | Median age (IQR) | ||
2008 | 656 (42.6) | 28 (20–54) | 884 (57.4) | 38 (21–59) | <0.001 |
2009 | 682 (39.7) | 26 (20–55) | 1037 (60.3) | 38 (21–59) | <0.001 |
2010 | 625 (43.0) | 33 (20–59) | 829 (57.0) | 38 (21–60) | 0.046 |
2011 | 581 (38.7) | 29 (21–56) | 920 (61.3) | 37 (21–59) | 0.056 |
2012 | 538 (41.0) | 28 (21–55) | 775 (59.0) | 39 (22–59) | 0.001 |
2013 | 518 (40.1) | 30 (22–59) | 773 (59.9) | 37 (23–60) | 0.131 |
2014 | 513 (37.9) | 37 (23–60) | 841 (62.1) | 38 (22–61) | 0.609 |
2015 | 421 (38.6) | 42 (24–63) | 669 (61.4) | 34 (23–60) | 0.002 |
2016 | 398 (35.9) | 51 (26–67) | 711 (64.1) | 42 (23–63) | <0.001 |
2017 | 469 (38.1) | 48 (26–65) | 763 (61.9) | 49 (26–65) | 0.780 |
Total | 5401 (39.7) | 34 (21–60) | 8202 (60.3) | 39 (22–61) | <0.001 |
Time trends of diagnostic delay from 2008 to 2017
Year | Median delay time (IQR) | Crude HR (95% CI) |
P
| Adjusted HR (95% CI)* |
P
|
---|---|---|---|---|---|
2008 | 60 (31–93) | 1 | – | 1 | – |
2009 | 34 (16–77) | 1.31 (1.03–1.67) | 0.026 | 1.31 (1.03–1.66) | 0.028 |
2010 | 34 (17–68) | 1.42 (1.17–1.71) | <0.001 | 1.41 (1.18–1.69) | <0.001 |
2011 | 29 (14–59) | 1.71 (1.40–2.08) | <0.001 | 1.69 (1.39–2.06) | <0.001 |
2012 | 30 (13–59) | 1.67 (1.36–2.05) | <0.001 | 1.63 (1.32–2.00) | <0.001 |
2013 | 29 (14–57) | 1.61 (1.26–2.06) | <0.001 | 1.55 (1.22–1.97) | <0.001 |
2014 | 32 (15–60) | 1.68 (1.40–2.03) | <0.001 | 1.61 (1.34–1.92) | <0.001 |
2015 | 31 (14–60) | 1.66 (1.37–2.02) | <0.001 | 1.58 (1.30–1.92) | <0.001 |
2016 | 30 (13–59) | 1.69 (1.24–2.32) | 0.001 | 1.63 (1.18–2.25) | 0.003 |
2017 | 33 (16–71) | 1.28 (1.01–1.64) | 0.044 | 1.29 (1.02–1.62) | 0.030 |
2008–2017 | 33 (16–65) | – | – | – |
Variance components estimation each year
Random-effects Parameter | Estimate* | Standard error | 95%CI |
---|---|---|---|
Dispensaries | |||
Var (2008) | 0.18 | 0.09 | 0.07–0.46 |
Var (2009) | 0.37 | 0.17 | 0.15–0.92 |
Var (2010) | 0.13 | 0.06 | 0.49–0.32 |
Var (2011) | 0.12 | 0.06 | 0.04–0.32 |
Var (2012) | 0.12 | 0.06 | 0.04–0.33 |
Var (2013) | 0.25 | 0.12 | 0.10–0.64 |
Var (2014) | 0.28 | 0.13 | 0.11–0.71 |
Var (2015) | 0.05 | 0.04 | 0.01–0.20 |
Var (2016) | 0.13 | 0.07 | 0.05–0.37 |
Var (2017) | 0.03 | 0.02 | 0.01–0.12 |
Time trends of diagnostic delay by gender from 2008 to 2017
Year | Female | Male | Adjusted female: male (HR, 95%CI) |
P
|
---|---|---|---|---|
Median delay time (IQR) | Median delay time (IQR) | |||
2008 | 60 (31–97) | 59 (31–91) | 0.99 (0.89–1.12)* | 0.986 |
2009 | 35 (16–79) | 34 (16–75) | 1.05 (0.95–1.17)* | 0.331 |
2010 | 34 (17–71) | 34 (17–66) | 0.94 (0.84–1.04)* | 0.221 |
2011 | 30 (14–61) | 28 (15–57) | 0.93 (0.83–1.03)* | 0.147 |
2012 | 31 (13–57) | 30 (14–61) | 0.99 (0.88–1.11)* | 0.836 |
2013 | 30 (16–63) | 29 (14–53) | 0.91 (0.81–1.02)* | 0.099 |
2014 | 31 (15–60) | 32 (15–60) | 0.99 (0.86–1.12)* | 0.927 |
2015 | 32 (17–61) | 29 (13–59) | 0.91 (0.80–1.05)* | 0.191 |
2016 | 29 (13–57) | 30 (13–61) | 0.96 (0.84–1.10)* | 0.570 |
2017 | 36 (19–72) | 32 (15–69) | 0.95 (0.84–1.07)* | 0.385 |
2008–2017 | 34 (16–67) | 32 (15–63) | 0.95 (0.91–0.99)† | 0.022 |
Time trends of diagnostic delay by age group from 2008 to 2017
Year | Age>45 years | Age ≤ 45 years | Adjusted >45: ≤45 (HR, 95%CI) |
P
| ||
---|---|---|---|---|---|---|
N (%) | Median delay time (IQR) | N (%) | Median delay time (IQR) | |||
2008 | 526 | 61 (35–104) | 769 | 51 (31–89) | 0.84 (0.75–0.94) * | 0.002 |
2009 | 644 | 42 (20–98) | 929 | 32 (14–66) | 0.82 (0.74–0.90) * | <0.001 |
2010 | 583 | 35 (18–72) | 865 | 34 (16–66) | 0.92 (0.83–1.02) * | 0.128 |
2011 | 570 | 30 (15–63) | 911 | 28 (14–56) | 0.76 (0.68–0.85) * | <0.001 |
2012 | 511 | 33 (15–65) | 783 | 28 (12–54) | 0.74 (0.66–0.83) * | <0.001 |
2013 | 511 | 30 (16–61) | 748 | 29 (13–55) | 0.82 (0.73–0.93) * | 0.001 |
2014 | 524 | 31 (14–63) | 726 | 32 (15–57) | 0.93 (0.82–1.04) * | 0.195 |
2015 | 390 | 32 (16–63) | 556 | 31 (13–57) | 0.92 (0.80–1.05) * | 0.198 |
2016 | 485 | 31 (14–62) | 510 | 27 (12–57) | 0.84 (0.73–0.95) * | 0.007 |
2017 | 617 | 33 (15–70) | 534 | 32 (17–72) | 0.99 (0.88–1.11) * | 0.857 |
2008–2017 | 5361 | 35 (17–70) | 7331 | 32 (15–62) | 0.87 (0.82–0.93)† | <0.001 |
Time trends of diagnostic delay by smear result from 2008 to 2017
Year | Smear positive | Smear negative | Adjusted Pos:Neg (HR, 95%CI) |
P
| ||
---|---|---|---|---|---|---|
N (%) | Median delay time (IQR) | N (%) | Median delay time (IQR) | |||
2008 | 518 | 61 (33–122) | 777 | 58 (31–88) | 0.77 (0.69–0.86) * | <0.001 |
2009 | 551 | 43 (17–93) | 1022 | 32 (15–70) | 0.83 (0.74–0.93) * | 0.001 |
2010 | 628 | 36 (17–70) | 820 | 33 (17–66) | 0.92 (0.83–1.02) * | 0.124 |
2011 | 599 | 29 (14–59) | 882 | 29 (15–59) | 0.98 (0.88–1.09) * | 0.742 |
2012 | 340 | 31 (14–60) | 954 | 30 (13–58) | 0.97 (0.86–1.11) * | 0.693 |
2013 | 236 | 30 (15–61) | 1023 | 29 (14–56) | 0.91 (0.78–1.06) * | 0.228 |
2014 | 169 | 29 (15–60) | 1081 | 32 (15–60) | 1.07 (0.90–1.26) * | 0.453 |
2015 | 107 | 21 (12–39) | 839 | 32 (15–62) | 1.44 (1.17–1.78) * | 0.001 |
2016 | 104 | 25 (14–62) | 891 | 30 (13–59) | 0.89 (0.72–1.10) * | 0.268 |
2017 | 294 | 53 (20–184) | 857 | 31 (15–62) | 0.45 (0.39–0.52) * | <0.001 |
2008–2017 | 3546 | 36 (17–74) | 9146 | 32 (15–62) | 0.86 (0.78–0.95)† | 0.002 |