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Erschienen in: Intensive Care Medicine 2/2021

07.08.2020 | Original

Trends in clinical profiles, organ support use and outcomes of patients with cancer requiring unplanned ICU admission: a multicenter cohort study

verfasst von: Fernando G. Zampieri, Thiago G. Romano, Jorge I. F. Salluh, Leandro U. Taniguchi, Pedro V. Mendes, Antonio P. Nassar Jr, Roberto Costa, William N. Viana, Marcelo O. Maia, Mariza F. A. Lima, Sylas B. Cappi, Alexandre G. R. Carvalho, Fernando V. C. De Marco, Marcelo S. Santino, Eric Perecmanis, Fabio G. Miranda, Grazielle V. Ramos, Aline R. Silva, Paulo M. Hoff, Fernando A. Bozza, Marcio Soares

Erschienen in: Intensive Care Medicine | Ausgabe 2/2021

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Abstract

Purpose

To describe trends in outcomes of cancer patients with unplanned admissions to intensive-care units (ICU) according to cancer type, organ support use, and performance status (PS) over an 8-year period.

Methods

We retrospectively analyzed prospectively collected data from all cancer patients admitted to 92 medical–surgical ICUs from July/2011 to June/2019. We assessed trends in mortality through a Bayesian hierarchical model adjusted for relevant clinical confounders and whether there was a reduction in ICU length-of-stay (LOS) over time using a competing risk model.

Results

32,096 patients (8.7% of all ICU admissions; solid tumors, 90%; hematological malignancies, 10%) were studied. Bed/days use by cancer patients increased up to more than 30% during the period. Overall adjusted mortality decreased by 9.2% [95% credible interval (CI), 13.1–5.6%]. The largest reductions in mortality occurred in patients without need for organ support (9.6%) and in those with need for mechanical ventilation (MV) only (11%). Smallest reductions occurred in patients requiring MV, vasopressors, and dialysis (3.9%) simultaneously. Survival gains over time decreased as PS worsened. Lung cancer patients had the lowest decrease in mortality. Each year was associated with a lower sub-hazard for ICU death [SHR 0.93 (0.91–0.94)] and a higher chance of being discharged alive from the ICU earlier [SHR 1.01 (1–1.01)].

Conclusion

Outcomes in critically ill cancer patients improved in the past 8 years, with reductions in both mortality and ICU LOS, suggesting improvements in overall care. However, outcomes remained poor in patients with lung cancer, requiring multiple organ support and compromised PS.
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Literatur
12.
Zurück zum Zitat Azoulay E, Mokart D, Pène F et al (2013) Outcomes of critically ill patients with hematologic malignancies: prospective multicenter data from France and Belgium–a groupe de recherche respiratoire en réanimation onco-hématologique study. J Clin Oncol Off J Am Soc Clin Oncol 31:2810–2818. https://doi.org/10.1200/JCO.2012.47.2365CrossRef Azoulay E, Mokart D, Pène F et al (2013) Outcomes of critically ill patients with hematologic malignancies: prospective multicenter data from France and Belgium–a groupe de recherche respiratoire en réanimation onco-hématologique study. J Clin Oncol Off J Am Soc Clin Oncol 31:2810–2818. https://​doi.​org/​10.​1200/​JCO.​2012.​47.​2365CrossRef
Metadaten
Titel
Trends in clinical profiles, organ support use and outcomes of patients with cancer requiring unplanned ICU admission: a multicenter cohort study
verfasst von
Fernando G. Zampieri
Thiago G. Romano
Jorge I. F. Salluh
Leandro U. Taniguchi
Pedro V. Mendes
Antonio P. Nassar Jr
Roberto Costa
William N. Viana
Marcelo O. Maia
Mariza F. A. Lima
Sylas B. Cappi
Alexandre G. R. Carvalho
Fernando V. C. De Marco
Marcelo S. Santino
Eric Perecmanis
Fabio G. Miranda
Grazielle V. Ramos
Aline R. Silva
Paulo M. Hoff
Fernando A. Bozza
Marcio Soares
Publikationsdatum
07.08.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Intensive Care Medicine / Ausgabe 2/2021
Print ISSN: 0342-4642
Elektronische ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-020-06184-2

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