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Cancer Chemotherapy and Pharmacology

Erschienen in:

15.10.2016 | Review Article

Trends on polymer- and lipid-based nanostructures for parenteral drug delivery to tumors

verfasst von: Elham Ajorlou, Ahmad Yari Khosroushahi

Erschienen in: Cancer Chemotherapy and Pharmacology | Ausgabe 2/2017

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Abstract

Purpose

The dawn of the state-of-the-art methods of cancer treatments, nano-based delivery systems, has dispensed with the mainstream chemotherapy for being inadequate in yielding productive results and the numerous reported side effects. The popularity of this complementary approach in the course of the last two decades has been primarily attributed to its capacity to elevate the therapeutic index of anticancer drugs as well as removing the impassable delivery barriers in solid tumors with the minimal damage to the normal tissues.

Methods

The PubMed database was consulted to compile this review.

Results

A wide range of minuscule organic and inorganic nanomaterials, with dimensions not exceeding hundred nanometers, has led to hope for cancer therapy to flare-up once again due to possessing a number of exclusive traits for passive and active tumor targeting, some of which are EPR effect, high interstitial pressure of tumor, overexpressed receptors and angiogenesis. Although a limited number of liposomal and polymer-based therapeutic nanoparticles have gained applicability, a vast number of nanoparticles are still being trailed in order to be fully developed.

Conclusions

This study provides an overview of the advantages/disadvantages of nanocarriers for cancer drug delivery.

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Titel: Trends on polymer- and lipid-based nanostructures for parenteral drug delivery to tumors
verfasst von: Elham Ajorlou
Ahmad Yari Khosroushahi
Publikationsdatum: 15.10.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Chemotherapy and Pharmacology / Ausgabe 2/2017
Print ISSN: 0344-5704
Elektronische ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-016-3168-6

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Trends on polymer- and lipid-based nanostructures for parenteral drug delivery to tumors

Abstract

Purpose

Methods

Results

Conclusions

Neu im Fachgebiet Onkologie

Prostatakarzinom: EU initiiert neues Screeningkonzept

Blasenkarzinom – Biomarker statt Zytologie?

Stereotaktische Radiatio schlägt konventionelle Bestrahlung

Adjuvante Brustkrebstherapie: Doppelt hält besser

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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