Trichogerminoma with malignant transformation
- 24.01.2025
- BRIEF REPORT
- Verfasst von
- Thibault Kervarrec
- Maxence Mancini
- Anne Tallet
- Samia Mourah
- Maxime Battistella
- Eric Frouin
- Erschienen in
- Virchows Archiv | Ausgabe 4/2025
Abstract
Trichogerminoma (TG) is a rare adnexal tumor with hair follicle differentiation with less than 50 cases reported in the literature. In 2022, by investigating the genetic profile of 21 cases, our group identified recurrent rearrangements of the GRHL1/2/3 genes in this tumor entity, suggesting such alteration as the main oncogenic driver in TG. Up to now, only one TG case of malignant transformation has been reported. In the present letter, we report a second case of TG with malignant transformation and provide molecular characterization of this tumor.
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- Titel
- Trichogerminoma with malignant transformation
- Verfasst von
-
Thibault Kervarrec
Maxence Mancini
Anne Tallet
Samia Mourah
Maxime Battistella
Eric Frouin
- Publikationsdatum
- 24.01.2025
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Virchows Archiv / Ausgabe 4/2025
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307 - DOI
- https://doi.org/10.1007/s00428-025-04032-6
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