Skip to main content
Erschienen in: Journal of Cancer Research and Clinical Oncology 9/2016

23.01.2016 | Review – Cancer Research

TRPM8: a potential target for cancer treatment

verfasst von: Zhaoguo Liu, Hongyan Wu, Zhonghong Wei, Xu Wang, Peiliang Shen, Siliang Wang, Aiyun Wang, Wenxing Chen, Yin Lu

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 9/2016

Einloggen, um Zugang zu erhalten

Abstract

Transient receptor potential (TRP) cation channel superfamily plays critical roles in variety of processes, including temperature perception, pain transduction, vasorelaxation, male fertility, and tumorigenesis. One of seven families within the TRP superfamily of ion channels, the melastatin, or TRPM family comprises a group of eight structurally and functionally diverse channels. Of all the members of TRPM subfamily, TRPM8 is the most notable one. A lot of literatures have demonstrated that transient receptor potential melastatin 8 (TRPM8) could perform a myriad of functions in vertebrates and invertebrates alike. In addition to its well-known function in cold sensation, TRPM8 has an emerging role in a variety of biological systems, including thermoregulation, cancer, bladder function, and asthma. Recent studies have shown that TRPM8 is necessary to the initiation and progression of tumors, and the aberrant expression of TRPM8 was found in varieties of tumors, such as prostate tumor, melanoma, breast adenocarcinoma, bladder cancer, and colorectal cancer, making it a novel molecular target potentially useful in the diagnosis and treatment of cancer. This review outlines our current understanding on the role of TRPM8 in occurrence and development of different kinds of tumor and also includes discussion about the regulation of TRPM8 during carcinogenesis as well as therapeutic potential of targeting TRPM8 in tumor, which may be utilized for a potential pharmacological use as a target for anti-cancer therapy.
Literatur
Zurück zum Zitat Akiba S, Sato T (2004) Cellular function of calcium-independent phospholipase A2. Biol Pharm Bull 27:1174–1178PubMedCrossRef Akiba S, Sato T (2004) Cellular function of calcium-independent phospholipase A2. Biol Pharm Bull 27:1174–1178PubMedCrossRef
Zurück zum Zitat Alvarez JV, Pan TC, Ruth J, Feng Y, Zhou A, Pant D, Grimley JS, Wandless TJ, Demichele A, Chodosh LA (2013) Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell 24:30–44. doi:10.1016/j.ccr.2013.05.007 PubMedCrossRef Alvarez JV, Pan TC, Ruth J, Feng Y, Zhou A, Pant D, Grimley JS, Wandless TJ, Demichele A, Chodosh LA (2013) Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. Cancer Cell 24:30–44. doi:10.​1016/​j.​ccr.​2013.​05.​007 PubMedCrossRef
Zurück zum Zitat Andrews MD, Af Forselles K, Beaumont K, Galan SR, Glossop PA, Grenie M, Jessiman A, Kenyon AS, Lunn G, Maw G, Owen RM, Pryde DC, Roberts D, Tran TD (2015) Discovery of a selective TRPM8 antagonist with clinical efficacy in cold-related pain. ACS Med Chem Lett 6:419–424. doi:10.1021/ml500479v PubMedPubMedCentralCrossRef Andrews MD, Af Forselles K, Beaumont K, Galan SR, Glossop PA, Grenie M, Jessiman A, Kenyon AS, Lunn G, Maw G, Owen RM, Pryde DC, Roberts D, Tran TD (2015) Discovery of a selective TRPM8 antagonist with clinical efficacy in cold-related pain. ACS Med Chem Lett 6:419–424. doi:10.​1021/​ml500479v PubMedPubMedCentralCrossRef
Zurück zum Zitat Anzalone CL, Cohen PR, Migden MR, Tannir NM (2013) Mohs surgery in metastatic cancer: renal cell carcinoma solitary cutaneous metastasis and visceral tumor metastases to skin treated with microscopically controlled surgical excision. Int J Dermatol 52:856–861. doi:10.1111/ijd.12021 PubMedCrossRef Anzalone CL, Cohen PR, Migden MR, Tannir NM (2013) Mohs surgery in metastatic cancer: renal cell carcinoma solitary cutaneous metastasis and visceral tumor metastases to skin treated with microscopically controlled surgical excision. Int J Dermatol 52:856–861. doi:10.​1111/​ijd.​12021 PubMedCrossRef
Zurück zum Zitat Asuthkar S, Velpula KK, Elustondo PA, Demirkhanyan L, Zakharian E (2015) TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells. Oncotarget 6:17221–17236PubMedPubMedCentralCrossRef Asuthkar S, Velpula KK, Elustondo PA, Demirkhanyan L, Zakharian E (2015) TRPM8 channel as a novel molecular target in androgen-regulated prostate cancer cells. Oncotarget 6:17221–17236PubMedPubMedCentralCrossRef
Zurück zum Zitat Augustinakova A, Kodet R (2011) Gastrointestinal stromal tumor molecular diagnostics in relation to the prediction of a therapeutic response to targeted biological therapy. Ceskoslov Patol 47:148–152 Augustinakova A, Kodet R (2011) Gastrointestinal stromal tumor molecular diagnostics in relation to the prediction of a therapeutic response to targeted biological therapy. Ceskoslov Patol 47:148–152
Zurück zum Zitat Bai VU, Murthy S, Chinnakannu K, Muhletaler F, Tejwani S, Barrack ER, Kim SH, Menon M, Veer Reddy GP (2010) Androgen regulated TRPM8 expression: a potential mRNA marker for metastatic prostate cancer detection in body fluids. Int J Oncol 36:443–450PubMed Bai VU, Murthy S, Chinnakannu K, Muhletaler F, Tejwani S, Barrack ER, Kim SH, Menon M, Veer Reddy GP (2010) Androgen regulated TRPM8 expression: a potential mRNA marker for metastatic prostate cancer detection in body fluids. Int J Oncol 36:443–450PubMed
Zurück zum Zitat Bao P, Zhao W, Li Y, Liu Y, Zhou Y, Liu C (2015) Protective effect of ulinastatin in patients with non-small cell lung cancer after radiation therapy: a randomized, placebo-controlled study. Med Oncol 32:405. doi:10.1007/s12032-014-0405-x PubMedCrossRef Bao P, Zhao W, Li Y, Liu Y, Zhou Y, Liu C (2015) Protective effect of ulinastatin in patients with non-small cell lung cancer after radiation therapy: a randomized, placebo-controlled study. Med Oncol 32:405. doi:10.​1007/​s12032-014-0405-x PubMedCrossRef
Zurück zum Zitat Bates DO, Catalano PJ, Symonds KE, Varey AH, Ramani P, O’Dwyer PJ, Giantonio BJ, Meropol NJ, Benson AB, Harper SJ (2012) Association between VEGF splice isoforms and progression-free survival in metastatic colorectal cancer patients treated with bevacizumab. Clin Cancer Res 18:6384–6391. doi:10.1158/1078-0432.CCR-12-2223 PubMedPubMedCentralCrossRef Bates DO, Catalano PJ, Symonds KE, Varey AH, Ramani P, O’Dwyer PJ, Giantonio BJ, Meropol NJ, Benson AB, Harper SJ (2012) Association between VEGF splice isoforms and progression-free survival in metastatic colorectal cancer patients treated with bevacizumab. Clin Cancer Res 18:6384–6391. doi:10.​1158/​1078-0432.​CCR-12-2223 PubMedPubMedCentralCrossRef
Zurück zum Zitat Borrelli F, Pagano E, Romano B, Panzera S, Maiello F, Coppola D, De Petrocellis L, Buono L, Orlando P, Izzo AA (2014) Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. Carcinogenesis 35:2787–2797. doi:10.1093/carcin/bgu205 PubMedCrossRef Borrelli F, Pagano E, Romano B, Panzera S, Maiello F, Coppola D, De Petrocellis L, Buono L, Orlando P, Izzo AA (2014) Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. Carcinogenesis 35:2787–2797. doi:10.​1093/​carcin/​bgu205 PubMedCrossRef
Zurück zum Zitat Chen W, Lu Y, Wu J, Gao M, Wang A, Xu B (2011a) Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis. Cancer Chemother Pharmacol 67:799–808. doi:10.1007/s00280-010-1378-x PubMedCrossRef Chen W, Lu Y, Wu J, Gao M, Wang A, Xu B (2011a) Beta-elemene inhibits melanoma growth and metastasis via suppressing vascular endothelial growth factor-mediated angiogenesis. Cancer Chemother Pharmacol 67:799–808. doi:10.​1007/​s00280-010-1378-x PubMedCrossRef
Zurück zum Zitat Chen ZJ, Roberts K, Decker R, Pathare P, Rockwell S, Nath R (2011b) The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers. Phys Med Biol 56:4895–4912. doi:10.1088/0031-9155/56/15/016 PubMedCrossRef Chen ZJ, Roberts K, Decker R, Pathare P, Rockwell S, Nath R (2011b) The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers. Phys Med Biol 56:4895–4912. doi:10.​1088/​0031-9155/​56/​15/​016 PubMedCrossRef
Zurück zum Zitat Clapham DE, Julius D, Montell C, Schultz G (2005) International Union of Pharmacology. XLIX. Nomenclature and structure–function relationships of transient receptor potential channels. Pharmacol Rev 57:427–450. doi:10.1124/pr.57.4.6 PubMedCrossRef Clapham DE, Julius D, Montell C, Schultz G (2005) International Union of Pharmacology. XLIX. Nomenclature and structure–function relationships of transient receptor potential channels. Pharmacol Rev 57:427–450. doi:10.​1124/​pr.​57.​4.​6 PubMedCrossRef
Zurück zum Zitat Cosens DJ, Manning A (1969) Abnormal electroretinogram from a Drosophila mutant. Nature 224:285–287PubMedCrossRef Cosens DJ, Manning A (1969) Abnormal electroretinogram from a Drosophila mutant. Nature 224:285–287PubMedCrossRef
Zurück zum Zitat DeFalco J, Duncton MA, Emerling D (2011) TRPM8 biology and medicinal chemistry. Curr Top Med Chem 11:2237–2252PubMedCrossRef DeFalco J, Duncton MA, Emerling D (2011) TRPM8 biology and medicinal chemistry. Curr Top Med Chem 11:2237–2252PubMedCrossRef
Zurück zum Zitat Du GJ, Li JH, Liu WJ, Liu YH, Zhao B, Li HR, Hou XD, Li H, Qi XX, Duan YJ (2014) The combination of TRPM8 and TRPA1 expression causes an invasive phenotype in lung cancer. Tumour Biol 35:1251–1261. doi:10.1007/s13277-013-1167-3 PubMedCrossRef Du GJ, Li JH, Liu WJ, Liu YH, Zhao B, Li HR, Hou XD, Li H, Qi XX, Duan YJ (2014) The combination of TRPM8 and TRPA1 expression causes an invasive phenotype in lung cancer. Tumour Biol 35:1251–1261. doi:10.​1007/​s13277-013-1167-3 PubMedCrossRef
Zurück zum Zitat Fixemer T, Wissenbach U, Flockerzi V, Bonkhoff H (2003) Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene 22:7858–7861. doi:10.1038/sj.onc.1206895 PubMedCrossRef Fixemer T, Wissenbach U, Flockerzi V, Bonkhoff H (2003) Expression of the Ca2+-selective cation channel TRPV6 in human prostate cancer: a novel prognostic marker for tumor progression. Oncogene 22:7858–7861. doi:10.​1038/​sj.​onc.​1206895 PubMedCrossRef
Zurück zum Zitat Gardiner JC, Kirkup AJ, Curry J, Humphreys S, O'Regan P, Postlethwaite M, Young KC, Kitching L, Ethell BT, Winpenny D, McMurray G (2014) The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist. Eur J Pharmacol 740:398–409. doi:10.1016/j.ejphar.2014.07.022 PubMedCrossRef Gardiner JC, Kirkup AJ, Curry J, Humphreys S, O'Regan P, Postlethwaite M, Young KC, Kitching L, Ethell BT, Winpenny D, McMurray G (2014) The role of TRPM8 in the Guinea-pig bladder-cooling reflex investigated using a novel TRPM8 antagonist. Eur J Pharmacol 740:398–409. doi:10.​1016/​j.​ejphar.​2014.​07.​022 PubMedCrossRef
Zurück zum Zitat Hecquet CM, Zhang M, Mittal M, Vogel SM, Di A, Gao X, Bonini MG, Malik AB (2014) Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis. Circ Res 114:469–479. doi:10.1161/CIRCRESAHA.114.302414 PubMedCrossRef Hecquet CM, Zhang M, Mittal M, Vogel SM, Di A, Gao X, Bonini MG, Malik AB (2014) Cooperative interaction of trp melastatin channel transient receptor potential (TRPM2) with its splice variant TRPM2 short variant is essential for endothelial cell apoptosis. Circ Res 114:469–479. doi:10.​1161/​CIRCRESAHA.​114.​302414 PubMedCrossRef
Zurück zum Zitat Keh SM, Facer P, Yehia A, Sandhu G, Saleh HA, Anand P (2011) The menthol and cold sensation receptor TRPM8 in normal human nasal mucosa and rhinitis. Rhinology 49:453–457. doi:10.4193/Rhino11.089 PubMed Keh SM, Facer P, Yehia A, Sandhu G, Saleh HA, Anand P (2011) The menthol and cold sensation receptor TRPM8 in normal human nasal mucosa and rhinitis. Rhinology 49:453–457. doi:10.​4193/​Rhino11.​089 PubMed
Zurück zum Zitat Kijpornyongpan T, Sereemaspun A, Chanchao C (2014) Dose-dependent cytotoxic effects of menthol on human malignant melanoma A-375 cells: correlation with TRPM8 transcript expression. Asian Pac J Cancer Prev 15:1551–1556PubMedCrossRef Kijpornyongpan T, Sereemaspun A, Chanchao C (2014) Dose-dependent cytotoxic effects of menthol on human malignant melanoma A-375 cells: correlation with TRPM8 transcript expression. Asian Pac J Cancer Prev 15:1551–1556PubMedCrossRef
Zurück zum Zitat Knowlton WM, McKemy DD (2011) TRPM8: from cold to cancer, peppermint to pain. Curr Pharm Biotechnol 12:68–77PubMedCrossRef Knowlton WM, McKemy DD (2011) TRPM8: from cold to cancer, peppermint to pain. Curr Pharm Biotechnol 12:68–77PubMedCrossRef
Zurück zum Zitat Kong YH, Syed Zanaruddin SN, Lau SH, Ramanathan A, Kallarakkal TG, Vincent-Chong VK, Wan Mustafa WM, Abraham MT, Abdul Rahman ZA, Zain RB, Cheong SC (2015) Co-expression of TWIST1 and ZEB2 in oral squamous cell carcinoma is associated with poor survival. PLoS One 10:e0134045. doi:10.1371/journal.pone.0134045 PubMedPubMedCentralCrossRef Kong YH, Syed Zanaruddin SN, Lau SH, Ramanathan A, Kallarakkal TG, Vincent-Chong VK, Wan Mustafa WM, Abraham MT, Abdul Rahman ZA, Zain RB, Cheong SC (2015) Co-expression of TWIST1 and ZEB2 in oral squamous cell carcinoma is associated with poor survival. PLoS One 10:e0134045. doi:10.​1371/​journal.​pone.​0134045 PubMedPubMedCentralCrossRef
Zurück zum Zitat Kulkarni P (2009) TRPM8 and prostate cancer: to overexpress or repress, that is the question-comment on “Effects of TRPM8 on proliferation and motility of prostate cancer PC-3 cells” by Yang ZH et al. in Asian Journal of Andrology. Asian J Androl 11:150–151. doi:10.1038/aja.2009.13 PubMedPubMedCentralCrossRef Kulkarni P (2009) TRPM8 and prostate cancer: to overexpress or repress, that is the question-comment on “Effects of TRPM8 on proliferation and motility of prostate cancer PC-3 cells” by Yang ZH et al. in Asian Journal of Andrology. Asian J Androl 11:150–151. doi:10.​1038/​aja.​2009.​13 PubMedPubMedCentralCrossRef
Zurück zum Zitat Landsberg JW, Yuan JX (2004) Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. News Physiol Sci 19:44–50PubMed Landsberg JW, Yuan JX (2004) Calcium and TRP channels in pulmonary vascular smooth muscle cell proliferation. News Physiol Sci 19:44–50PubMed
Zurück zum Zitat Lashinger ES, Steiginga MS, Hieble JP, Leon LA, Gardner SD, Nagilla R, Davenport EA, Hoffman BE, Laping NJ, Su X (2008) AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol 295:F803–F810. doi:10.1152/ajprenal.90269.2008 PubMedCrossRef Lashinger ES, Steiginga MS, Hieble JP, Leon LA, Gardner SD, Nagilla R, Davenport EA, Hoffman BE, Laping NJ, Su X (2008) AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol 295:F803–F810. doi:10.​1152/​ajprenal.​90269.​2008 PubMedCrossRef
Zurück zum Zitat Lehto SG, Weyer AD, Zhang M, Youngblood BD, Wang J, Wang W, Kerstein PC, Davis C, Wild KD, Stucky CL, Gavva NR (2015) AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia. Naunyn Schmiedebergs Arch Pharmacol 388:465–476. doi:10.1007/s00210-015-1090-9 PubMedPubMedCentralCrossRef Lehto SG, Weyer AD, Zhang M, Youngblood BD, Wang J, Wang W, Kerstein PC, Davis C, Wild KD, Stucky CL, Gavva NR (2015) AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia. Naunyn Schmiedebergs Arch Pharmacol 388:465–476. doi:10.​1007/​s00210-015-1090-9 PubMedPubMedCentralCrossRef
Zurück zum Zitat Liapis V, Labrinidis A, Zinonos I, Hay S, Ponomarev V, Panagopoulos V, DeNichilo M, Ingman W, Atkins GJ, Findlay DM, Zannettino AC, Evdokiou A (2015) Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma. Cancer Lett 357:160–169. doi:10.1016/j.canlet.2014.11.020 PubMedCrossRef Liapis V, Labrinidis A, Zinonos I, Hay S, Ponomarev V, Panagopoulos V, DeNichilo M, Ingman W, Atkins GJ, Findlay DM, Zannettino AC, Evdokiou A (2015) Hypoxia-activated pro-drug TH-302 exhibits potent tumor suppressive activity and cooperates with chemotherapy against osteosarcoma. Cancer Lett 357:160–169. doi:10.​1016/​j.​canlet.​2014.​11.​020 PubMedCrossRef
Zurück zum Zitat Lu S, Slominski A, Yang SE, Sheehan C, Ross J, Carlson JA (2010) The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia-associated transcription factor (MITF) and other melanogenesis-related proteins in normal and pathological skin, hair follicles and melanocytic nevi. J Cutan Pathol 37(Suppl. 1):26–40. doi:10.1111/j.1600-0560.2010.01504.x PubMedPubMedCentralCrossRef Lu S, Slominski A, Yang SE, Sheehan C, Ross J, Carlson JA (2010) The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia-associated transcription factor (MITF) and other melanogenesis-related proteins in normal and pathological skin, hair follicles and melanocytic nevi. J Cutan Pathol 37(Suppl. 1):26–40. doi:10.​1111/​j.​1600-0560.​2010.​01504.​x PubMedPubMedCentralCrossRef
Zurück zum Zitat Masamoto Y, Kawabata F, Fushiki T (2009) Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice. Biosci Biotechnol Biochem 73:1021–1027. doi:10.1271/bbb.80796 PubMedCrossRef Masamoto Y, Kawabata F, Fushiki T (2009) Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice. Biosci Biotechnol Biochem 73:1021–1027. doi:10.​1271/​bbb.​80796 PubMedCrossRef
Zurück zum Zitat Mergler S, Strowski MZ, Kaiser S, Plath T, Giesecke Y, Neumann M, Hosokawa H, Kobayashi S, Langrehr J, Neuhaus P, Plockinger U, Wiedenmann B, Grotzinger C (2007) Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells. Neuroendocrinology 85:81–92. doi:10.1159/000101693 PubMedCrossRef Mergler S, Strowski MZ, Kaiser S, Plath T, Giesecke Y, Neumann M, Hosokawa H, Kobayashi S, Langrehr J, Neuhaus P, Plockinger U, Wiedenmann B, Grotzinger C (2007) Transient receptor potential channel TRPM8 agonists stimulate calcium influx and neurotensin secretion in neuroendocrine tumor cells. Neuroendocrinology 85:81–92. doi:10.​1159/​000101693 PubMedCrossRef
Zurück zum Zitat Merritt JE, Armstrong WP, Benham CD, Hallam TJ, Jacob R, Jaxa-Chamiec A, Leigh BK, McCarthy SA, Moores KE, Rink TJ (1990) SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem J 271:515–522PubMedPubMedCentralCrossRef Merritt JE, Armstrong WP, Benham CD, Hallam TJ, Jacob R, Jaxa-Chamiec A, Leigh BK, McCarthy SA, Moores KE, Rink TJ (1990) SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem J 271:515–522PubMedPubMedCentralCrossRef
Zurück zum Zitat Meseguer V, Karashima Y, Talavera K, D'Hoedt D, Donovan-Rodriguez T, Viana F, Nilius B, Voets T (2008) Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole. J Neurosci 28:576–586. doi:10.1523/JNEUROSCI.4772-07.2008 PubMedCrossRef Meseguer V, Karashima Y, Talavera K, D'Hoedt D, Donovan-Rodriguez T, Viana F, Nilius B, Voets T (2008) Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole. J Neurosci 28:576–586. doi:10.​1523/​JNEUROSCI.​4772-07.​2008 PubMedCrossRef
Zurück zum Zitat Mistretta F, Buffi NM, Lughezzani G, Lista G, Larcher A, Fossati N, Abrate A, Dell’Oglio P, Montorsi F, Guazzoni G, Lazzeri M (2014) Bladder cancer and urothelial impairment: the role of TRPV1 as potential drug target. Biomed Res Int 2014:987149. doi:10.1155/2014/987149 PubMedPubMedCentralCrossRef Mistretta F, Buffi NM, Lughezzani G, Lista G, Larcher A, Fossati N, Abrate A, Dell’Oglio P, Montorsi F, Guazzoni G, Lazzeri M (2014) Bladder cancer and urothelial impairment: the role of TRPV1 as potential drug target. Biomed Res Int 2014:987149. doi:10.​1155/​2014/​987149 PubMedPubMedCentralCrossRef
Zurück zum Zitat Montell C, Birnbaumer L, Flockerzi V (2002) The TRP channels, a remarkably functional family. Cell 108:595–598PubMedCrossRef Montell C, Birnbaumer L, Flockerzi V (2002) The TRP channels, a remarkably functional family. Cell 108:595–598PubMedCrossRef
Zurück zum Zitat Mukkamala A, Allam CL, Ellison JS, Hafez KS, Miller DC, Montgomery JS, Weizer AZ, Wolf JS Jr (2014) Tumor enucleation vs sharp excision in minimally invasive partial nephrectomy: technical benefit without impact on functional or oncologic outcomes. Urology 83:1294–1299. doi:10.1016/j.urology.2014.02.007 PubMedCrossRef Mukkamala A, Allam CL, Ellison JS, Hafez KS, Miller DC, Montgomery JS, Weizer AZ, Wolf JS Jr (2014) Tumor enucleation vs sharp excision in minimally invasive partial nephrectomy: technical benefit without impact on functional or oncologic outcomes. Urology 83:1294–1299. doi:10.​1016/​j.​urology.​2014.​02.​007 PubMedCrossRef
Zurück zum Zitat Ohmi M, Shishido Y, Inoue T, Ando K, Fujiuchi A, Yamada A, Watanabe S, Kawamura K (2014) Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist. Bioorg Med Chem Lett 24:5364–5368. doi:10.1016/j.bmcl.2014.10.074 PubMedCrossRef Ohmi M, Shishido Y, Inoue T, Ando K, Fujiuchi A, Yamada A, Watanabe S, Kawamura K (2014) Identification of a novel 2-pyridyl-benzensulfonamide derivative, RQ-00203078, as a selective and orally active TRPM8 antagonist. Bioorg Med Chem Lett 24:5364–5368. doi:10.​1016/​j.​bmcl.​2014.​10.​074 PubMedCrossRef
Zurück zum Zitat Okamoto Y, Ohkubo T, Ikebe T, Yamazaki J (2012) Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines. Int J Oncol 40:1431–1440. doi:10.3892/ijo.2012.1340 PubMed Okamoto Y, Ohkubo T, Ikebe T, Yamazaki J (2012) Blockade of TRPM8 activity reduces the invasion potential of oral squamous carcinoma cell lines. Int J Oncol 40:1431–1440. doi:10.​3892/​ijo.​2012.​1340 PubMed
Zurück zum Zitat Patel R, Goncalves L, Newman R, Jiang FL, Goldby A, Reeve J, Hendrick A, Teall M, Hannah D, Almond S, Brice N, Dickenson AH (2014) Novel TRPM8 antagonist attenuates cold hypersensitivity after peripheral nerve injury in rats. J Pharmacol Exp Ther 349:47–55. doi:10.1124/jpet.113.211243 PubMedCrossRef Patel R, Goncalves L, Newman R, Jiang FL, Goldby A, Reeve J, Hendrick A, Teall M, Hannah D, Almond S, Brice N, Dickenson AH (2014) Novel TRPM8 antagonist attenuates cold hypersensitivity after peripheral nerve injury in rats. J Pharmacol Exp Ther 349:47–55. doi:10.​1124/​jpet.​113.​211243 PubMedCrossRef
Zurück zum Zitat Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A (2002) A TRP channel that senses cold stimuli and menthol. Cell 108:705–715PubMedCrossRef Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A (2002) A TRP channel that senses cold stimuli and menthol. Cell 108:705–715PubMedCrossRef
Zurück zum Zitat Rohacs T, Lopes CM, Michailidis I, Logothetis DE (2005) PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci 8:626–634. doi:10.1038/nn1451 PubMedCrossRef Rohacs T, Lopes CM, Michailidis I, Logothetis DE (2005) PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci 8:626–634. doi:10.​1038/​nn1451 PubMedCrossRef
Zurück zum Zitat Saadoun H, Lamy PJ, Thezenas S, Pouderoux S, Bibeau F, Montels F, Romieu G, Colombo PE, Gutowski M, Jacot W (2014) Prognostic impact of the inclusion of uPA/PAI-1 tumor levels in the current adjuvant treatment decision-making for early breast cancer. Future Oncol 10:195–209. doi:10.2217/fon.13.177 PubMedCrossRef Saadoun H, Lamy PJ, Thezenas S, Pouderoux S, Bibeau F, Montels F, Romieu G, Colombo PE, Gutowski M, Jacot W (2014) Prognostic impact of the inclusion of uPA/PAI-1 tumor levels in the current adjuvant treatment decision-making for early breast cancer. Future Oncol 10:195–209. doi:10.​2217/​fon.​13.​177 PubMedCrossRef
Zurück zum Zitat Sanchez MG, Sanchez AM, Collado B, Malagarie-Cazenave S, Olea N, Carmena MJ, Prieto JC, Diaz-Laviada II (2005) Expression of the transient receptor potential vanilloid 1 (TRPV1) in LNCaP and PC-3 prostate cancer cells and in human prostate tissue. Eur J Pharmacol 515:20–27. doi:10.1016/j.ejphar.2005.04.010 PubMedCrossRef Sanchez MG, Sanchez AM, Collado B, Malagarie-Cazenave S, Olea N, Carmena MJ, Prieto JC, Diaz-Laviada II (2005) Expression of the transient receptor potential vanilloid 1 (TRPV1) in LNCaP and PC-3 prostate cancer cells and in human prostate tissue. Eur J Pharmacol 515:20–27. doi:10.​1016/​j.​ejphar.​2005.​04.​010 PubMedCrossRef
Zurück zum Zitat Sotiropoulou N, Bravou V, Kounelis S, Damaskou V, Papaspirou E, Papadaki H (2010) Tumour expression of lymphangiogenic growth factors but not lymphatic vessel density is implicated in human cervical cancer progression. Pathology 42:629–636. doi:10.3109/00313025.2010.522174 PubMedCrossRef Sotiropoulou N, Bravou V, Kounelis S, Damaskou V, Papaspirou E, Papadaki H (2010) Tumour expression of lymphangiogenic growth factors but not lymphatic vessel density is implicated in human cervical cancer progression. Pathology 42:629–636. doi:10.​3109/​00313025.​2010.​522174 PubMedCrossRef
Zurück zum Zitat Tsavaler L, Shapero MH, Morkowski S, Laus R (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760–3769PubMed Tsavaler L, Shapero MH, Morkowski S, Laus R (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760–3769PubMed
Zurück zum Zitat Vanden Abeele F, Zholos A, Bidaux G, Shuba Y, Thebault S, Beck B, Flourakis M, Panchin Y, Skryma R, Prevarskaya N (2006) Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids. J Biol Chem 281:40174–40182. doi:10.1074/jbc.M605779200 PubMedCrossRef Vanden Abeele F, Zholos A, Bidaux G, Shuba Y, Thebault S, Beck B, Flourakis M, Panchin Y, Skryma R, Prevarskaya N (2006) Ca2+-independent phospholipase A2-dependent gating of TRPM8 by lysophospholipids. J Biol Chem 281:40174–40182. doi:10.​1074/​jbc.​M605779200 PubMedCrossRef
Zurück zum Zitat Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B (2004) The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430:748–754. doi:10.1038/nature02732 PubMedCrossRef Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B (2004) The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430:748–754. doi:10.​1038/​nature02732 PubMedCrossRef
Zurück zum Zitat Wang G, Lemos JR, Iadecola C (2004) Herbal alkaloid tetrandrine: from an ion channel blocker to inhibitor of tumor proliferation. Trends Pharmacol Sci 25:120–123PubMedCrossRef Wang G, Lemos JR, Iadecola C (2004) Herbal alkaloid tetrandrine: from an ion channel blocker to inhibitor of tumor proliferation. Trends Pharmacol Sci 25:120–123PubMedCrossRef
Zurück zum Zitat Weil A, Moore SE, Waite NJ, Randall A, Gunthorpe MJ (2005) Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8. Mol Pharmacol 68:518–527. doi:10.1124/mol.105.012146 PubMed Weil A, Moore SE, Waite NJ, Randall A, Gunthorpe MJ (2005) Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8. Mol Pharmacol 68:518–527. doi:10.​1124/​mol.​105.​012146 PubMed
Zurück zum Zitat Winchester WJ, Gore K, Glatt S, Petit W, Gardiner JC, Conlon K, Postlethwaite M, Saintot PP, Roberts S, Gosset JR, Matsuura T, Andrews MD, Glossop PA, Palmer MJ, Clear N, Collins S, Beaumont K, Reynolds DS (2014) Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther 351:259–269. doi:10.1124/jpet.114.216010 PubMedCrossRef Winchester WJ, Gore K, Glatt S, Petit W, Gardiner JC, Conlon K, Postlethwaite M, Saintot PP, Roberts S, Gosset JR, Matsuura T, Andrews MD, Glossop PA, Palmer MJ, Clear N, Collins S, Beaumont K, Reynolds DS (2014) Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther 351:259–269. doi:10.​1124/​jpet.​114.​216010 PubMedCrossRef
Zurück zum Zitat Yee NS, Brown RD, Lee MS, Zhou W, Jensen C, Gerke H, Yee RK (2012a) TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target. Cancer Biol Ther 13:592–599. doi:10.4161/cbt.20079 PubMedPubMedCentralCrossRef Yee NS, Brown RD, Lee MS, Zhou W, Jensen C, Gerke H, Yee RK (2012a) TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target. Cancer Biol Ther 13:592–599. doi:10.​4161/​cbt.​20079 PubMedPubMedCentralCrossRef
Zurück zum Zitat Yu S, Xu Z, Zou C, Wu D, Wang Y, Yao X, Ng CF, Chan FL (2014) Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2-independent and RACK1-mediated mechanism of HIF-1alpha stabilization. J Pathol 234:514–525. doi:10.1002/path.4413 PubMedCrossRef Yu S, Xu Z, Zou C, Wu D, Wang Y, Yao X, Ng CF, Chan FL (2014) Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2-independent and RACK1-mediated mechanism of HIF-1alpha stabilization. J Pathol 234:514–525. doi:10.​1002/​path.​4413 PubMedCrossRef
Zurück zum Zitat Zheng T, Yin D, Lu Z, Wang J, Li Y, Chen X, Liang Y, Song X, Qi S, Sun B, Xie C, Meng X, Pan S, Liu J, Jiang H, Liu L (2014) Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in hepatocellular carcinoma. Mol Cancer 13:133. doi:10.1186/1476-4598-13-133 PubMedPubMedCentralCrossRef Zheng T, Yin D, Lu Z, Wang J, Li Y, Chen X, Liang Y, Song X, Qi S, Sun B, Xie C, Meng X, Pan S, Liu J, Jiang H, Liu L (2014) Nutlin-3 overcomes arsenic trioxide resistance and tumor metastasis mediated by mutant p53 in hepatocellular carcinoma. Mol Cancer 13:133. doi:10.​1186/​1476-4598-13-133 PubMedPubMedCentralCrossRef
Metadaten
Titel
TRPM8: a potential target for cancer treatment
verfasst von
Zhaoguo Liu
Hongyan Wu
Zhonghong Wei
Xu Wang
Peiliang Shen
Siliang Wang
Aiyun Wang
Wenxing Chen
Yin Lu
Publikationsdatum
23.01.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 9/2016
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-015-2112-1

Weitere Artikel der Ausgabe 9/2016

Journal of Cancer Research and Clinical Oncology 9/2016 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.