Tuberous sclerosis complex (TSC) is a challenge for physicians to diagnose and treat because it affects every patient in a different way. Multi-organs could be involved such as brain, skin, kidney, lung, retina, and heart. This adds to difficulties of accurately diagnosing and treating the disease [
1]. For those who suffer from refractory epilepsy, simultaneous PET/MR of neuro system plays an important role in the evaluation of TSC, not only in initial diagnosis but also in the indication, timing of surgery, and planning the treatment [
2]. …