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01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Journal of Medical Case Reports 1/2014

Tubulocystic renal cell carcinoma in the left kidney: a case report

Journal of Medical Case Reports > Ausgabe 1/2014
Yusuke Ishibashi, Takuya Koie, Naoki Fujita, Tendo Satoh, Jotaro Mikami, Shingo Hatakeyama, Chikara Ohyama, Yuki Tobisawa, Tohru Yoneyama
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-8-265) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

YT drafted the manuscript. TK was involved in the drafting of the manuscript. NF, TS, and JM performed the clinical follow-up. YI and SH performed the operation. YT and TY analyzed the pathological specimens. TK and CO were responsible for the conception and design of this study, interpretation of the data, and critical revision of the manuscript. All authors have read and approved the final manuscript.



Tubulocystic renal carcinoma is a rare tumor and has been recently recognized as a neoplastic entity. We report a case of tubulocystic renal carcinoma in the left kidney and present a review of relevant literature.

Case presentation

A 35-year-old Japanese woman visited our hospital with the chief complaint of left-sided back pain. Computed tomography revealed a hemorrhagic cyst (size, 7×8cm) in the upper pole of her left kidney. Approximately 3 years after the initial diagnosis, she complained of left-sided back pain again. Magnetic resonance imaging revealed an enlarged left renal cyst (size, 10×12cm) with a slightly enhanced cystic wall. The tumor was clinically diagnosed as a renal cell carcinoma in the cT2N0M0 stage, which arose from the cyst wall; therefore, left nephrectomy was performed. On histological examination, the tumor showed circumscribed proliferation with cystically dilated tubules. The tubules and cysts were lined by a single layer of flat, hobnail, and cuboidal cells. Immunohistochemical analysis revealed that the tumor cells were strongly positive for E-cadherin and P504S.


Examination of more cases of tubulocystic renal carcinoma is required to better understand the biology of this tumor and to ascertain its prognosis.

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