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International Journal of Colorectal Disease
Erschienen in: International Journal of Colorectal Disease 7/2020

17.04.2020 | Original Article

Tumor-associated macrophage infiltration and prognosis in colorectal cancer: systematic review and meta-analysis

verfasst von: Jinyuan Li, Linhai Li, Yuejin Li, Yaxin Long, Quan Zhao, Yiming Ouyang, Weimin Bao, Kunmei Gong

Erschienen in: International Journal of Colorectal Disease | Ausgabe 7/2020

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Abstract

Background

Tumor-associated macrophages (TAMs) are key components of colorectal cancer (CRC) microenvironment, but their role in CRC prognosis is not fully defined.

Objective

This study aimed to evaluate prognostic value of different types and distribution of TAMs in CRC.

Methods

Total 27 studies with 6115 patients were searched from PubMed and Embase and analyzed to determine the association between TAMs, including distinct TAM subsets and infiltration location, and CRC survival. The prognostic impact of TAMs on CRC was further stratified by tumor type and mismatch repair system (MMR) status.

Results

A pooled analysis indicated that high density of TAMs in CRC tissue was significantly associated with favorable 5-year overall survival (OS) but not with disease-free survival (DFS). CD 68+ TAM subset correlated with better 5-year OS, while neither CD68+NOS2+ M1 subset nor CD163+ M2 subset was correlated with 5-year OS. Increased CD68+ TAM infiltration in tumor stroma but not in tumor islet predicted improved 5-year OS. Stratification by tumor type and MMR status showed that in colon cancer or MMR-proficient CRC, elevated TAM density was associated with better 5-year OS.

Conclusions

High infiltration of CD68+ TAMs could be a favorable prognostic marker in CRC. Future therapies stimulating CD68+ TAM infiltration may be promising in CRC treatment.
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Metadaten
Titel
Tumor-associated macrophage infiltration and prognosis in colorectal cancer: systematic review and meta-analysis
verfasst von
Jinyuan Li
Linhai Li
Yuejin Li
Yaxin Long
Quan Zhao
Yiming Ouyang
Weimin Bao
Kunmei Gong
Publikationsdatum
17.04.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
International Journal of Colorectal Disease / Ausgabe 7/2020
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-020-03593-z

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