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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

Tumor characteristics and the clinical outcome of invasive lobular carcinoma compared to infiltrating ductal carcinoma in a Chinese population

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
A-Yong Cao, Liang Huang, Jiong Wu, Jin-Song Lu, Guang-Yu Liu, Zhen-Zhou Shen, Zhi-Ming Shao, Gen-Hong Di
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-152) contains supplementary material, which is available to authorized users.

Competing interests

There is no any conflict of interest about the study.

Authors’ contributions

GD carried out the study conception and design. AC was responsible for data collecting and manuscript writing. MH, ZMS and JW participated in the technique support and results analysis. GYL and JSL participated in the design of the study and performed the statistical analysis. ZZS conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.

Abstract

Background

We sought to compare the baseline demographics, standard pathologic factors and long- term clinical outcomes between ILC and infiltrating ductal carcinoma (IDC) using a large database.

Methods

Clinicopathologic features, overall survival (OS), and recurrence/metastasis-free survival (RFS) were compared between 2,202 patients with IDC and 215 patients with ILC.

Results

ILC was significantly more likely to be associated with a favorable phenotype, but the incidence of contralateral breast cancer was higher for ILC patients than for IDC patients (8.4% vs. 3.9%; P =0.001). The frequencies of recurrence/metastasis (P = 0.980) and death (P = 0.064) were similar among patients with IDC and patients with ILC after adjustment for tumor size and nodal status. The median follow-up was 42.8 months.

Conclusions

Chinese women with ILCs do not have better clinical outcomes than their counterparts with IDC. Management decisions should be based on individual patient and tumor biologic characteristics, and not on lobular histology.
Zusatzmaterial
Authors’ original file for figure 1
12957_2012_1117_MOESM1_ESM.tiff
Authors’ original file for figure 2
12957_2012_1117_MOESM2_ESM.tiff
Authors’ original file for figure 3
12957_2012_1117_MOESM3_ESM.tiff
Literatur
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