The online version of this article (doi:10.1186/1477-7819-10-152) contains supplementary material, which is available to authorized users.
There is no any conflict of interest about the study.
GD carried out the study conception and design. AC was responsible for data collecting and manuscript writing. MH, ZMS and JW participated in the technique support and results analysis. GYL and JSL participated in the design of the study and performed the statistical analysis. ZZS conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.
We sought to compare the baseline demographics, standard pathologic factors and long- term clinical outcomes between ILC and infiltrating ductal carcinoma (IDC) using a large database.
Clinicopathologic features, overall survival (OS), and recurrence/metastasis-free survival (RFS) were compared between 2,202 patients with IDC and 215 patients with ILC.
ILC was significantly more likely to be associated with a favorable phenotype, but the incidence of contralateral breast cancer was higher for ILC patients than for IDC patients (8.4% vs. 3.9%; P =0.001). The frequencies of recurrence/metastasis (P = 0.980) and death (P = 0.064) were similar among patients with IDC and patients with ILC after adjustment for tumor size and nodal status. The median follow-up was 42.8 months.
Chinese women with ILCs do not have better clinical outcomes than their counterparts with IDC. Management decisions should be based on individual patient and tumor biologic characteristics, and not on lobular histology.
Borst MJ, Ingold JA: Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery. 1993, 114: 637-641. PubMed
Sastre-Garau X, Jouve M, Asselain B, Vincent-Salomon A, Beuzeboc P, Dorval T, Durand JC, Fourquet A, Pouillart P: Infiltrating lobular carcinoma of the breast. Clinicopathologic analysis of 975 cases with reference to data on conservative therapy and metastatic patterns. Cancer. 1996, 77: 113-120. 10.1002/(SICI)1097-0142(19960101)77:1<113::AID-CNCR19>3.0.CO;2-8. CrossRefPubMed
Sasson AR, Fowble B, Hanlon AL, Torosian MH, Freedman G, Boraas M, Sigurdson ER, Hoffman JP, Eisenberg BL, Patchefsky A: Lobular carcinoma in situ increases the risk of local recurrence in selected patients with stages I and II breast carcinoma treated with conservative surgery and radiation. Cancer. 2001, 91: 1862-1869. 10.1002/1097-0142(20010515)91:10<1862::AID-CNCR1207>3.0.CO;2-#. CrossRefPubMed
Franceschini G, Manno A, Mulè A, Verbo A, Rizzo G, Sermoneta D, Petito L, D'alba P, Maggiore C, Terribile D, Masetti R, Coco C: Gastro-intestinal symptoms as clinical manifestation of peritoneal and retroperitoneal spread of an invasive lobular breast cancer: report of a case and review of the literature. BMC Cancer. 2006, 6: 193-10.1186/1471-2407-6-193. PubMedCentralCrossRefPubMed
Fortunato L, Mascaro A, Poccia I, Andrich R, Amini M, Costarelli L, Cortese G, Farina M, Vitelli C: Lobular breast cancer: same survival and local control compared with ductal cancer, but should both be treated the same way? Analysis of an institutional database over a 10-year period. Ann Surg Oncol. 2012, 19: 1107-1114. 10.1245/s10434-011-1907-9. CrossRefPubMed
Rakha EA, Reis-Filho JS, Baehner F, Dabbs DJ, Decker T, Eusebi V, Fox SB, Ichihara S, Jacquemier J, Lakhani SR, Palacios J, Richardson AL, Schnitt SJ, Schmitt FC, Tan PH, Tse GM, Badve S, Ellis IO: Breast cancer prognostic classification in the molecular era: the role of histological grade. Breast Cancer Res. 2010, 12: 207- PubMedCentralPubMed
Papaioannou N, Zervoudis S, Grammatikakis I, Peitsidis P, Palvakis K, Youssef TF: Metastatic lobular carcinoma of the breast to the vulva: a case report and review of the literature. J Egypt Natl Canc Inst. 2010, 22: 57-60. PubMed
Pestalozzi BC, Zahrieh D, Mallon E, Gusterson BA, Price KN, Gelber RD, Holmberg SB, Lindtner J, Snyder R, Thürlimann B, Murray E, Viale G, Castiglione-Gertsch M, Coates AS, Goldhirsch A: International Breast Cancer Study Group: Distinct clinical and prognostic features of infiltrating lobular carcinoma of the breast: combined results of 15 International Breast Cancer Study Group clinical trials. J Clin Oncol. 2008, 26: 3006-3014. 10.1200/JCO.2007.14.9336. CrossRefPubMed
Adams AL, Li Y, Pfeifer JD, Hameed O: Nuclear grade and survival in invasive lobular carcinoma: a case series with long-term follow-up. Breast J. 2010, 16: 445-447. PubMed
- Tumor characteristics and the clinical outcome of invasive lobular carcinoma compared to infiltrating ductal carcinoma in a Chinese population
- BioMed Central
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