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Cancer Immunology, Immunotherapy

Erschienen in:

01.11.2005 | Symposium Paper

Tumor counterattack: fact or fiction?

verfasst von: Frederik H. Igney, Peter H. Krammer

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 11/2005

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Abstract

Cancer development relies on a variety of mechanisms that facilitate tumor growth despite the presence of a functioning immune system. Understanding these mechanisms may foster novel therapeutic approaches for oncology and organ transplantation. By expression of the apoptosis-inducing protein CD95L (FasL, APO-1L, CD178), tumors may eliminate tumor-infiltrating lymphocytes and suppress anti-tumor immune responses, a phenomenon called “tumor counterattack”. On the one hand, preliminary evidence of tumor counterattack in human tumors exists, and CD95L expression can prevent T-cell responses in vitro. On the other hand, CD95L-expressing tumors are rapidly rejected and induce inflammation in mice. Here, we summarize and discuss the consequences of CD95L expression of tumor cells and its contribution to immune escape.

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Titel: Tumor counterattack: fact or fiction?
verfasst von: Frederik H. Igney
Peter H. Krammer
Publikationsdatum: 01.11.2005
Verlag: Springer-Verlag
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 11/2005
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-005-0680-7

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