Tumor location and patient age predict biological signatures of high-grade gliomas
- 31.08.2017
- Original Article
Erschienen in:
- Verfasst von
- Roberto Altieri
- Francesco Zenga
- Alessandro Ducati
- Antonio Melcarne
- Fabio Cofano
- Marco Mammi
- Giuseppe Di Perna
- Riccardo Savastano
- Diego Garbossa
- Erschienen in
- Neurosurgical Review | Ausgabe 2/2018
Abstract
Prognostic factors for high-grade gliomas include patient age, IDH1 mutation, MGMT methylation, and Ki67 value. We assessed the predictive role of topographic location of gliomas for their biological signatures. Collecting all neuroradiological and histological data of patients with histologically proven HGG, we performed a retrospective monocentric study. A predictive value of frontal location for a lower Ki67 value (especially in the left hemisphere) and mutation of IDH1 (especially in the right hemisphere) was found. Temporal location was predictive for IDH1 wild-type. Involvement of the parietal lobe was found to be predictive of methylated MGMT, while insular lobe involvement predicted an unmethylated MGMT. There was no statistically significant difference of IDH1 mutation and MGMT methylation between left and right sides.
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- Titel
- Tumor location and patient age predict biological signatures of high-grade gliomas
- Verfasst von
-
Roberto Altieri
Francesco Zenga
Alessandro Ducati
Antonio Melcarne
Fabio Cofano
Marco Mammi
Giuseppe Di Perna
Riccardo Savastano
Diego Garbossa
- Publikationsdatum
- 31.08.2017
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Neurosurgical Review / Ausgabe 2/2018
Print ISSN: 0344-5607
Elektronische ISSN: 1437-2320 - DOI
- https://doi.org/10.1007/s10143-017-0899-8
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