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Erschienen in: Abdominal Radiology 4/2019

29.11.2018 | Review

Tumor markers: myths and facts unfolded

verfasst von: S. C. Faria, T. Sagebiel, M. Patnana, V. Cox, C. Viswanathan, C. Lall, A. Qayyum, P. R. Bhosale

Erschienen in: Abdominal Radiology | Ausgabe 4/2019

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Abstract

Objective

The purpose of this article is to review the most commonly used tumor markers in abdominal and pelvic tumors, describe their limitations and explain how to use them in the context of known cancer in order to optimize multidisciplinary care of oncologic patients.

Conclusion

Tumor markers are important for the diagnosis, staging, monitoring of treatment and detection of recurrence in many cancers. This knowledge is crucial in the daily interpretation of images of oncologic and non-oncologic patients. However, radiologists should also be aware of the limitations of the most commonly used tumor markers and they should not be used solely, but interpreted in conjunction with diagnostic imaging, clinical history and physical examination that will help optimize the multidisciplinary care and management of oncologic patients.
Literatur
6.
Zurück zum Zitat Goldstein MJ, Mitchell EP (2005) Carcinoembryonic antigen in the staging and follow-up of patients with colorectal cancer. Cancer Invest 23(4):338–351CrossRef Goldstein MJ, Mitchell EP (2005) Carcinoembryonic antigen in the staging and follow-up of patients with colorectal cancer. Cancer Invest 23(4):338–351CrossRef
9.
Zurück zum Zitat Wiratkapun S, Kraemer M, Seow-Choen F, Ho YH, Eu KW (2001) High preoperative serum carcinoembryonic antigen predicts metastatic recurrence in potentially curative colonic cancer: results of a five-year study. Dis Colon Rectum 44(2):231–235CrossRef Wiratkapun S, Kraemer M, Seow-Choen F, Ho YH, Eu KW (2001) High preoperative serum carcinoembryonic antigen predicts metastatic recurrence in potentially curative colonic cancer: results of a five-year study. Dis Colon Rectum 44(2):231–235CrossRef
15.
Zurück zum Zitat Konishi F (2002) CEA doubling time and CEA half-life in the prediction of recurrences after colorectal cancer surgery. Jpn J Clin Oncol 32(2):41–42CrossRef Konishi F (2002) CEA doubling time and CEA half-life in the prediction of recurrences after colorectal cancer surgery. Jpn J Clin Oncol 32(2):41–42CrossRef
18.
Zurück zum Zitat Vreugdenburg TD, Ma N, Duncan JK, et al. (2016) Comparative diagnostic accuracy of hepatocyte-specific gadoxetic acid (Gd-EOB-DTPA) enhanced MR imaging and contrast enhanced CT for the detection of liver metastases: a systematic review and meta-analysis. Int J Colorectal Dis 31(11):1739–1749. https://doi.org/10.1007/s00384-016-2664-9 CrossRefPubMed Vreugdenburg TD, Ma N, Duncan JK, et al. (2016) Comparative diagnostic accuracy of hepatocyte-specific gadoxetic acid (Gd-EOB-DTPA) enhanced MR imaging and contrast enhanced CT for the detection of liver metastases: a systematic review and meta-analysis. Int J Colorectal Dis 31(11):1739–1749. https://​doi.​org/​10.​1007/​s00384-016-2664-9 CrossRefPubMed
22.
Zurück zum Zitat Selzner M, Hany TF, Wildbrett P, et al. (2004) Does the novel PET/CT imaging modality impact on the treatment of patients with metastatic colorectal cancer of the liver? Ann Surg 240(6):1027–1034 ((discussion 1035–1026))CrossRef Selzner M, Hany TF, Wildbrett P, et al. (2004) Does the novel PET/CT imaging modality impact on the treatment of patients with metastatic colorectal cancer of the liver? Ann Surg 240(6):1027–1034 ((discussion 1035–1026))CrossRef
25.
34.
Zurück zum Zitat Makarewicz R, Lebioda A, Terlikiewicz J, Biedka M, Wisniewski T (2009) PSA bouncing after brachytherapy HDR and external beam radiation therapy: a study of 121 patients with minimum 5-years follow-up. J Contemp Brachyther 1(2):92–96 Makarewicz R, Lebioda A, Terlikiewicz J, Biedka M, Wisniewski T (2009) PSA bouncing after brachytherapy HDR and external beam radiation therapy: a study of 121 patients with minimum 5-years follow-up. J Contemp Brachyther 1(2):92–96
43.
Zurück zum Zitat Kew M (1974) Alpha-fetoprotein in primary liver cancer and other diseases. Gut 15(10):814–821CrossRef Kew M (1974) Alpha-fetoprotein in primary liver cancer and other diseases. Gut 15(10):814–821CrossRef
44.
Zurück zum Zitat Gupta S, Bent S, Kohlwes J (2003) Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C. A systematic review and critical analysis. Ann Intern Med 139(1):46–50CrossRef Gupta S, Bent S, Kohlwes J (2003) Test characteristics of alpha-fetoprotein for detecting hepatocellular carcinoma in patients with hepatitis C. A systematic review and critical analysis. Ann Intern Med 139(1):46–50CrossRef
45.
Zurück zum Zitat Trevisani F, D’Intino PE, Morselli-Labate AM, et al. (2001) Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status. J Hepatol 34(4):570–575CrossRef Trevisani F, D’Intino PE, Morselli-Labate AM, et al. (2001) Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status. J Hepatol 34(4):570–575CrossRef
48.
Zurück zum Zitat Johnson PJ, Williams R (1980) Serum alpha-fetoprotein estimations and doubling time in hepatocellular carcinoma: influence of therapy and possible value in early detection. J Natl Cancer Inst 64(6):1329–1332CrossRef Johnson PJ, Williams R (1980) Serum alpha-fetoprotein estimations and doubling time in hepatocellular carcinoma: influence of therapy and possible value in early detection. J Natl Cancer Inst 64(6):1329–1332CrossRef
51.
Zurück zum Zitat McIntire KR, Vogel CL, Primack A, Waldmann TA, Kyalwazi SK (1976) Effect of surgical and chemotherapeutic treatment on alpha-fetoprotein levels in patients with hepatocellular carcinoma. Cancer 37(2):677–683CrossRef McIntire KR, Vogel CL, Primack A, Waldmann TA, Kyalwazi SK (1976) Effect of surgical and chemotherapeutic treatment on alpha-fetoprotein levels in patients with hepatocellular carcinoma. Cancer 37(2):677–683CrossRef
54.
Zurück zum Zitat Oka H, Saito A, Ito K, et al. (2001) Multicenter prospective analysis of newly diagnosed hepatocellular carcinoma with respect to the percentage of Lens culinaris agglutinin-reactive alpha-fetoprotein. J Gastroenterol Hepatol 16(12):1378–1383CrossRef Oka H, Saito A, Ito K, et al. (2001) Multicenter prospective analysis of newly diagnosed hepatocellular carcinoma with respect to the percentage of Lens culinaris agglutinin-reactive alpha-fetoprotein. J Gastroenterol Hepatol 16(12):1378–1383CrossRef
60.
Zurück zum Zitat Del Villano BC, Brennan S, Brock P, et al. (1983) Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9. Clin Chem 29(3):549–552PubMed Del Villano BC, Brennan S, Brock P, et al. (1983) Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9. Clin Chem 29(3):549–552PubMed
61.
Zurück zum Zitat Poruk KE, Gay DZ, Brown K, et al. (2013) The clinical utility of CA 19-9 in pancreatic adenocarcinoma: diagnostic and prognostic updates. Curr Mol Med 13(3):340–351PubMedPubMedCentral Poruk KE, Gay DZ, Brown K, et al. (2013) The clinical utility of CA 19-9 in pancreatic adenocarcinoma: diagnostic and prognostic updates. Curr Mol Med 13(3):340–351PubMedPubMedCentral
73.
Zurück zum Zitat Petrucelli N, Daly MB, Feldman GL (1993) BRCA1 and BRCA2 hereditary breast and ovarian cancer. In: Pagon RA, Adam MP, Ardinger HH, et al. (eds) GeneReviews(R). Seattle: University of Washington, Seattle Petrucelli N, Daly MB, Feldman GL (1993) BRCA1 and BRCA2 hereditary breast and ovarian cancer. In: Pagon RA, Adam MP, Ardinger HH, et al. (eds) GeneReviews(R). Seattle: University of Washington, Seattle
75.
Zurück zum Zitat Bast RC Jr, Xu FJ, Yu YH, et al. (1998) CA 125: the past and the future. Int J Biol Mark 13(4):179–187CrossRef Bast RC Jr, Xu FJ, Yu YH, et al. (1998) CA 125: the past and the future. Int J Biol Mark 13(4):179–187CrossRef
81.
Zurück zum Zitat Balestreri L, Bison L, Sorio R, et al. (2002) Abdominal recurrence of ovarian cancer: value of abdominal MR in patients with positive CA125 and negative CT. Radiol Med 104(5–6):426–436PubMed Balestreri L, Bison L, Sorio R, et al. (2002) Abdominal recurrence of ovarian cancer: value of abdominal MR in patients with positive CA125 and negative CT. Radiol Med 104(5–6):426–436PubMed
90.
Zurück zum Zitat Jacobs I, Oram D, Fairbanks J, et al. (1990) A risk of malignancy index incorporating CA 125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer. Br J Obstet Gynaecol 97(10):922–929CrossRef Jacobs I, Oram D, Fairbanks J, et al. (1990) A risk of malignancy index incorporating CA 125, ultrasound and menopausal status for the accurate preoperative diagnosis of ovarian cancer. Br J Obstet Gynaecol 97(10):922–929CrossRef
91.
Zurück zum Zitat Tingulstad S, Hagen B, Skjeldestad FE, et al. (1996) Evaluation of a risk of malignancy index based on serum CA125, ultrasound findings and menopausal status in the pre-operative diagnosis of pelvic masses. Br J Obstet Gynaecol 103(8):826–831CrossRef Tingulstad S, Hagen B, Skjeldestad FE, et al. (1996) Evaluation of a risk of malignancy index based on serum CA125, ultrasound findings and menopausal status in the pre-operative diagnosis of pelvic masses. Br J Obstet Gynaecol 103(8):826–831CrossRef
93.
97.
Zurück zum Zitat Germa-Lluch JR, del Muro XG, Maroto P, et al. (2002) Clinical pattern and therapeutic results achieved in 1490 patients with germ-cell tumours of the testis: the experience of the Spanish germ-cell cancer group (GG). Eur Urol 42(6):553–562 ((discussion 562-553))CrossRef Germa-Lluch JR, del Muro XG, Maroto P, et al. (2002) Clinical pattern and therapeutic results achieved in 1490 patients with germ-cell tumours of the testis: the experience of the Spanish germ-cell cancer group (GG). Eur Urol 42(6):553–562 ((discussion 562-553))CrossRef
99.
Zurück zum Zitat Favilla V, Cimino S, Madonia M, Morgia G (2010) New advances in clinical biomarkers in testis cancer. Front Biosci (Elite Ed) 2:456–477 Favilla V, Cimino S, Madonia M, Morgia G (2010) New advances in clinical biomarkers in testis cancer. Front Biosci (Elite Ed) 2:456–477
103.
Zurück zum Zitat Modlin IM, Moss SF, Oberg K, et al. (2010) Gastrointestinal neuroendocrine (carcinoid) tumours: current diagnosis and management. Med J Aust 193(1):46–52PubMed Modlin IM, Moss SF, Oberg K, et al. (2010) Gastrointestinal neuroendocrine (carcinoid) tumours: current diagnosis and management. Med J Aust 193(1):46–52PubMed
108.
Zurück zum Zitat Bajetta E, Ferrari L, Martinetti A, et al. (1999) Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors. Cancer 86(5):858–865CrossRef Bajetta E, Ferrari L, Martinetti A, et al. (1999) Chromogranin A, neuron specific enolase, carcinoembryonic antigen, and hydroxyindole acetic acid evaluation in patients with neuroendocrine tumors. Cancer 86(5):858–865CrossRef
Metadaten
Titel
Tumor markers: myths and facts unfolded
verfasst von
S. C. Faria
T. Sagebiel
M. Patnana
V. Cox
C. Viswanathan
C. Lall
A. Qayyum
P. R. Bhosale
Publikationsdatum
29.11.2018
Verlag
Springer US
Erschienen in
Abdominal Radiology / Ausgabe 4/2019
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI
https://doi.org/10.1007/s00261-018-1845-0

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