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Journal of Neuro-Oncology

Erschienen in:

24.05.2018 | Topic Review

Tumor-related epilepsy: epidemiology, pathogenesis and management

verfasst von: Dillon Y. Chen, Clark C. Chen, John R. Crawford, Sonya G. Wang

Erschienen in: Journal of Neuro-Oncology | Ausgabe 1/2018

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Abstract

Introduction

Seizure is a common comorbidity in patients with brain tumor. It may be the presenting symptom or develop after the tumor diagnosis. The underlying pathophysiology of brain tumor-related epilepsy remains poorly understood.

Methods

A comprehensive literature review of Pubmed English articles from 1980–2017 was performed to summarize current knowledge and treatment options of brain tumor-related epilepsy.

Results

Multiple factors have been found to contribute to tumor-related epilepsy, including tumor type, speed of tumor growth, location, and tumor burden. The underlying pathogenesis of epilepsy is not clear but perturbations in the peri-tumoral regions, both structural and cellular communications, have been implicated.

Conclusions

Surgical and medical treatments of tumor-related epilepsy remain challenging as additional factors such as the extent of surgical resection, interactions with tumor-related oncological treatments and anti-epileptic medication related side effects need to be considered.

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Titel: Tumor-related epilepsy: epidemiology, pathogenesis and management
verfasst von: Dillon Y. Chen
Clark C. Chen
John R. Crawford
Sonya G. Wang
Publikationsdatum: 24.05.2018
Verlag: Springer US
Erschienen in: Journal of Neuro-Oncology / Ausgabe 1/2018
Print ISSN: 0167-594X
Elektronische ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-018-2862-0

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Tumor-related epilepsy: epidemiology, pathogenesis and management

Abstract

Introduction

Methods

Results

Conclusions

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Abstract

Introduction

Methods

Results

Conclusions

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