nach oben

Tumor Biology

Erschienen in:

15.02.2016 | Review

Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers

verfasst von: Shiwei He, Yancheng Zhong, Cijun Shuai, Dan Gao, Pingpin Wei, Guiyuan Li, Shuping Peng

Erschienen in: Tumor Biology | Ausgabe 5/2016

Einloggen, um Zugang zu erhalten

Abstract

Nasopharyngeal carcinoma-associated gene 6 (NGX6) is a membrane protein primarily located in the nuclear membrane and cell membrane. Several groups reported that NGX6 gene was down-regulated in nasopharyngeal carcinoma (NPC), gastric cancer, lung cancer, liver cancer, and colorectal cancer and even less in the carcinomas with metastasis. Current studies have demonstrated that NGX6 possesses various biological functions, such as regulating protein expression of related genes, involving cell signal transduction pathways, negatively controlling cell cycle progression, inhibiting angiogenesis, and increasing the sensitivity of patients to anti-cancer drugs. Some factors regulating the expression level of NGX6 gene also have been studied. The methylation of promoter of NGX6 and histone H3K9 negatively regulates its expression, similar to the function of transcription factor special protein-1 (Sp1). However, the regulatory factor early growth response gene 1 (Egr-1) is provided with positive regulation function. This review will summarize the progress of those studies on NGX6 and elucidate the potential application of NGX6 for some malignant diseases.

Cao Y, DePinho RA, Ernst M, Vousden K. Cancer research: past, present and future. Nat Rev Cancer. 2011;11(10):749–54.CrossRefPubMed

McNeish IA, Bell SJ, Lemoine NR. Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes. Gene Ther. 2004;11(6):497–503.CrossRefPubMed

Salazar-Montes AM, Hernandez-Ortega LD, Lucano-Landeros MS, Armendariz-Borunda J. New gene therapy strategies for hepatic fibrosis. World J Gastroenterol. 2015;21(13):3813–25.CrossRefPubMedPubMedCentral

Yang J, Bin L, Li Z, Zhang X, Qian J, Zhang B, et al. Refined localization and cloning of a novel putative tumor suppressor gene associated with nasopharyngeal carcinoma on chromosome 9p21-22. Chin J Cancer. 2000;19(1):6–9.

Ma J, Zhou J, Fan S, Wang L, Li X, Yan Q, et al. Role of a novel EGF-like domain-containing gene NGX6 in cell adhesion modulation in nasopharyngeal carcinoma cells. Carcinogenesis. 2005;26(2):281–91.CrossRefPubMed

Lin ZF, Shen XY, Lu FZ, Ruan Z, Huang HL, Zhen J. Reveals new lung adenocarcinoma cancer genes based on gene expression. Eur Rev Med Pharmacol. 2012;16(9):1249–56.

Su Z, Wang X, Shen S, Wang L, Li Y, Li N, et al. Expression of 2 transcripts of NGX6 gene in colorectal cancer and the correlation with carcinoembryonic antigen. J Cent South Univ (Med Sci). 2010;35(5):401–08.

Li X, Li J, Huang Y, Dong L, Zhang Q, Tan C, et al. Expression and purification of NGX6 in Escherichia coli. Life Sci Res. 2003;7(2):151–55.

Tang X, Long C, Liu F, Lv H, Hu J, Shen S. Expression of BRD7 and NGX6 gene in acute leukemia. Cancer Res Prev Treat. 2008;35(9):635–38.

10.

Peng SP, Li XL, Wang L, Ou-Yang J, Ma J, Wang LL, et al. The role of NGX6 and its deletion mutants in the proliferation, adhesion and migration of nasopharyngeal carcinoma 5-8F cells. Oncology. 2006;71(3–4):273–81.PubMed

11.

Wang L, Xiang B, Yi M, Zhang WL, Yang JB, Peng SP, et al. Identification of a new seven-span transmembrane protein: NGX6a is downregulated in nasopharyngeal carcinoma and is associated with tumor metastasis. J Histochem Cytochem. 2010;58(1):41–51.CrossRefPubMedPubMedCentral

12.

Liu MJ, Wang XY, Shen SR, Li N, Zhang DC, Peng Y, et al. Cloning and identification of promoter of suppressed-tumor gene NGX6. Prog Biochem Biophys. 2010;37(10):1082–9.CrossRef

13.

Ma J, Zhou J, Li X, Gong J, He X, Tang K, et al. Changes of expression profile induced by NGX6 transfection in nasopharyngeal carcinoma cells. Chin J Biochem Mol Biol. 2002;18(4):416–22.

14.

Wang L, Zhang Q, Ma J, Peng C, Cao L, Tang K, et al. Role of NGX6 in nasopharyngeal carcinoma with high ability of metastasis cell line 5-8F. Prog Biochem Biophys. 2005;32(7):618–24.

15.

Wang XY, Wu MH, Liu F, Li Y, Li N, Li GY, et al. Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells. Mol Cell Biochem. 2010;345(1–2):283–90.CrossRefPubMed

16.

Peng S, Fan S, Li X, Wang L, Liu H, Zhou M, et al. The expression of ezrin in NPC and its interaction with NGX6, a novel candidate suppressor. Cancer Sci. 2007;98(3):341–9.CrossRefPubMed

17.

Li X, Wu M, Li G. Functional genomics of nasopharyngeal carcinoma a susceptibility/suppressor gene. J Cent South Univ (Med Sci). 2007;33(7):553–58.

18.

Wang L, Li XL, Xiang B, Zhou M, Li XY, Xiong W, et al. NGX6a is degraded through a proteasome-dependent pathway without ubiquitination mediated by Ezrin, a cytoskeleton-membrane linker. J Biol Chem. 2014;289(52):35731–42.CrossRefPubMedPubMedCentral

19.

Guo Q, Shen S, Liao M, Lian P, Wang X. NGX6 inhibits cell invasion and adhesion through suppression of Wnt/beta-catenin signal pathway in colon cancer. Acta Biochim Biophys Sin (Shanghai). 2010;42(7):450–56.CrossRef

20.

Li Y, Luo Y, Wang X, Shen S, Yu H, Yang J, et al. Tumor suppressor gene NGX6 induces changes in protein expression profiles in colon cancer HT-29 cells. Acta Biochim Biophys Sin (Shanghai). 2012;44(7):584–90.CrossRef

21.

Lian P, Guo Q, Peng Y, Xiao Z, Liu F, Wang X, et al. Effect of NGX6 gene with 5-FU on the apoptosis of colon cancer cells. Chin J Clin Oncol. 2009;36(21):1239–42,47.

22.

Peng S, Li X, Li H, Wang L, Zhou M, Zhou H, et al. Inhibitory effect of NGX6 gene on migration and mobility of nasopharyngeal carcinoma cells. Chin J Biochem Mol Biol. 2007;23(4):309–15.

23.

Liu F, Wang XY, Lian P, Xiao ZM, Shen SR, Ma J, et al. Effect of NGX6 on gene expression profile of colon carcinoma cell line HT-29. Chin J Cancer. 2005;24(9):1064–70.

24.

Liu F, Shen S, Li H, Wang X, Peng Y, Liao M, et al. Effects of NGX6 on the transcriptional activation of β-catenin signal pathway. J Cent South Univ (Med Sci). 2007;32(6):985–91.

25.

Guo Q, Wu M, Lian P, Liao M, Xiao Z, Wang X, et al. Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/beta-catenin signaling pathway. Mol Cell Biochem. 2009;330(1–2):71–81.CrossRefPubMed

26.

Wu MH, Li XY, Li XL, Li GY. Signaling transduction network mediated by tumor suppressor/susceptibility genes in NPC. Curr Genom. 2009;10(4):216–22.CrossRef

27.

Wang L, Ma J, Li J, Li X, Zhang Q, Peng S, et al. NGX6 gene inhibits cell proliferation and plays a negative role in EGFR pathway in nasopharyngeal carcinoma cells. J Cell Biochem. 2005;95(1):64–73.CrossRefPubMed

28.

Wang L. Molecular mechanism of Ezrin facilitating degradation of NGX6a protein promoting invasion and metastasis in nasopharyngeal carcinoma cells [Doctoral thesis]. Hunan: Central South University; 2009.

29.

Peng Y, Li H, Wu M, Wang X, Fan S, Liu F, et al. NGX6 inhibits AP-1 and Ets-1 expression and down-regulates cyclin D1 in human colorectal cancer. Acta Biochim Biophys Sin (Shanghai). 2009;41(6):504–14.CrossRef

30.

Wang XY, Shen SR, Liu F, Peng Y, Li GY, Fan SQ. Inhibitory effects of NGX6 gene on EGFR/K-ras/JNK/c-Jun/cyclin D1 signal pathway in the colon cancer. Prog Biochem Biophys. 2008;35(5):570–6.

31.

Zhao WJ, Wang K. NGX6 expression improves the sensitivity of tamoxifen-resistant MCF-7 cells through modulation of the Smad signaling pathway. Int J Oncol. 2013;42(6):2060–68.PubMed

32.

Wang G, Jiang Q, Zhang R, Shen S, Li Y. Expression of NGX6, CyclinD1 protein in esophageal squamous cell carcinoma tissue and their significance. China Oncol. 2010;20(12):887–91.

33.

Wang XY, Shen SR, Liu F, Li XL, Fan SQ. Effects of NGX6 gene on cell cycle in colon cancer cell line HT-29. Prog Biochem Biophys. 2006;33(1):45–50.

34.

Ma J, Li J, Zhou J, Li XL, Tang K, Zhou M, et al. Profiling genes differentially expressed in NGX6 overexpressed nasopharyngeal carcinoma cells by cDNA array. J Cancer Res Clin Oncol. 2002;128(12):683–90.CrossRefPubMed

35.

Li J, Huang Y, Zhang Q, Tan C, Li X, Li G. NGX6 effect on the cell cycle of NPC cell line HNE1 cells. Life Sci Res. 2002;6(4):300–04.

36.

Zhang H, Tao F, Cao X, Yang Z. Expressions of NGX6 and p21 WAF1 in colorectal carcinoma and their clinical significance. Mod Pract Med. 2012;14(7):733–34,810.

37.

Lian P, Guo Q, Peng Y, Xiao Z, Liu F, Wang X, et al. Nasopharyngeal carcinoma-associated gene 6 inhibits tumor angiogenesis in colon cancer. World Chin J Digestol. 2009;17(25):2577–84.CrossRef

38.

Zhang J, Wang Z, Shi X, Meng W, Ma F, Wang J, et al. NGX6 gene combined with cisplatin in treatment of lung cancer in vitro and in vivo. Chin J Biochem Pharm. 2015;35(5):33–6.

39.

Fan S, Zhang W, Zhou M, Peng S, Li G. Study of in situ expression of NGX6 in the several common types of cancer and its clinical significance. Prog Biochem Biophys. 2008;35(9):1014–20.

40.

Wang X, Shen S, Liu H, Zhang X, Peng C, Huang H, et al. Effects of tumor suppressor gene NGX6 on growth of human colon cancer cell line HT-29. World Chin J Digestol. 2004;12(3):574–79.

41.

Zhang XM, Wang XY, Sheng SR, Wang JR, Li J. Expression of tumor related genes NGX6, NAG-7, BRD7 in gastric and colorectal cancer. World J Gastroenterol. 2003;9(8):1729–33.CrossRefPubMedPubMedCentral

42.

Xiao Z, Shen S, Lian P, Wang X, Liu F. Intraspleenic tumor model of nude mice in the anti-metastasis roles of a NGX6 gene against colon cancer. J Cent South Univ (Med Sci). 2007;32(5):753–57.

43.

Lian P, Guo Q, Peng Y, Xiao ZM, Liu F, Wang XY, et al. The role of NGX6 gene on apoptosis of human colon cancer. Prog Biochem Biophys. 2008;35(10):1154–60.

44.

Zhang X, Sheng S, Wang X, Wang J, Li J. Expression of tumor related gene NGX6 in gastric cancer and colorectal cancer. World Chin J Digestol. 2001;10(8):873–76.

45.

Xiao J, Zhou Y, Liu B. Correlation of NGX6 expression with clinicopathologic features and prognosis in colon cancer. Int J Clin Exp Med. 2015;8(8):13644–48.PubMedPubMedCentral

46.

Liu J, Zhu X, Xu X, Dai D. DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells. Med Oncol. 2014;31(1):817.CrossRefPubMed

47.

Zhang H, Cao X, Fan G, Sun G, Yang Z, Gu H, et al. Expression of NGX6 and cyclin D1 in gastric carcinoma and its clinical significance. Chin J Cancer Prev Treat. 2012;19(18):612–14.

48.

Xiao J, Shen S. Expression and significance of NGX6 gene in human hepatocellular carcinoma. J Cent South Univ (Med Sci). 2008;33(10):937–41.

49.

Eskandari-Nasab E, Hashemi M, Rezaei H, Fazaeli A, Mashhadi MA, Moghaddam SS, et al. Evaluation of UDP-glucuronosyltransferase 2B17 (UGT2B17) and dihydrofolate reductase (DHFR) genes deletion and the expression level of NGX6 mRNA in breast cancer. Mol Biol Rep. 2012;39(12):10531–39.CrossRefPubMed

50.

Xiao J, Zhou Y, Zhu W. Association of ultrasonographic features with NGX6 expression and prognosis in invasive ductal breast carcinoma. Int J Clin Exp Pathol. 2015;8(6):6458–65.PubMedPubMedCentral

51.

Xiong W, Zeng ZY, Li XL, Li WF, Li J, He L, et al. Single-nucleotide polymorphisms in NGX6 gene and their correlation with nasopharyngeal carcinoma. Acta Bioch Bioph Sin (Shanghai). 2002;34(4):512–15.

52.

Liu M, Peng Y, Wang X, Guo Q, Shen S, Li G. NGX6 gene mediated by promoter methylation as a potential molecular marker in colorectal cancer. BMC Cancer. 2010;10:160.CrossRefPubMedPubMedCentral

53.

Liu M, Wang X, Peng Y, Shen S, Li G. Egr-1 regulates the transcription of NGX6 gene through a Sp1/Egr-1 overlapping site in the promoter. BMC Mol Biol. 2014;15:14.CrossRefPubMedPubMedCentral

54.

Chew MMS, Gan SY, Khoo ASB, Tan EL. Interleukins, laminin and Epstein-Barr virus latent membrane protein 1 (EBV LMP1) Promote metastatic phenotype in nasopharyngeal carcinoma. BMC Cancer. 2010;10:574.CrossRefPubMedPubMedCentral

55.

Cross D, Burmester JK. Gene therapy for cancer treatment: past, present and future. Clin Med Res. 2006;4(3):218–27.CrossRefPubMedPubMedCentral

56.

Li J, Huang Y, Li W, Tan C, Zhang Q, Peng C, et al. The effects of NGX6 on cells from human nasopharyngeal carcinoma cell line HNE1. Chin J Biochem Mol Biol. 2002;18(4):398–03.

Titel: Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers
verfasst von: Shiwei He
Yancheng Zhong
Cijun Shuai
Dan Gao
Pingpin Wei
Guiyuan Li
Shuping Peng
Publikationsdatum: 15.02.2016
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 5/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-016-4966-5

Neu im Fachgebiet Onkologie

24.04.2024 | DGIM 2024 | Nachrichten

Springer Medizin

Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers

Abstract

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2016

MiR-195 inhibits the proliferation of human cervical cancer cells by directly targeting cyclin D1

Ultrastructural changes of mitochondria in human retinoblastoma: correlation with tumor differentiation and invasiveness

In search of underlying mechanisms and potential drugs of melphalan-induced vascular toxicity through retinal endothelial cells using bioinformatics approach

13-Oxyingenol dodecanoate, a cytotoxic ingenol derivative, induces mitochondrial apoptosis and caspase-dependent Akt decrease in K562 cells

Gankyrin regulates cell signaling network

Combinations of FUT2 gene polymorphisms and environmental factors are associated with oral cancer risk

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie