Tumoral calcinosis is rarely located in spine. A 55-year-old Japanese woman with cervical tumoral calcinosis is presented, along with a review of the literature relating to tumoral calcinosis in the spine. We discussed the etiology, diagnosis, and management of this condition.
We report a case of a patient with cervical tumoral calcinosis with end-stage renal disease. A computed tomography scan showed a lobulated, calcified mass around the right facet joint at the fourth-fifth cervical spine and calcifications were also observed in the right intervertebral foramens at fourth-fifth cervical spine and fifth-sixth cervical spine levels and the anterior wall of the spinal canal. By performing a cervical decompression and stabilization, the patient recovered from her neurological symptoms.
Although tumoral calcinosis is rarely located in the spine, it should be considered in the differential diagnosis of spinal lesions. If a calcified mass causes acute neurological symptoms, resection of the mass is still the most important treatment.
Inclan A, Leon PP, Camejo M. Tumoral calcinosis. J Am Med Ass. 1943;121:490–5. CrossRef
Carlson AP, Yonas HM, Turner PT. Disorders of tumoral calcification of the spine illustrative case study and review of the literature. J Spinal Disord. 2007;20(1):97–103. CrossRef
Emon ST, Bozkurt SU, Gercek A, Ozgen S. Tumoral calcinosis and epidural lipomatosis of the lumbar spine. Turk Neurosurg. 2011;21(1):110–2. PubMed
Matsukado K, Amano T, Itou O, Yuhi F, Nagata S. Tumoral calcinosis in the upper cervical spine causing progressive radiculomyelopathy. Neurol Med Chir (Tokyo). 2001;41(8):411–4. CrossRef
Mooney 3rd JF, Glazier SS. Tumoral calcinosis of the cervical spine in an infant. J Neurosrug. 1997;86(1):162. CrossRef
Rafaelsen S, Johansson S, Ræder H, Bjerknes R. Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature. BMC Genet. 2014;15:98. doi: 10.1186/s12863-014-0098-3. CrossRefPubMedPubMedCentral
Shah A, Miller CJ, Nast CC, Adams MD, Truitt B, Tayek JA, Tong L, Mehtani P, Monteon F, Sedor JR, Clinkenbeard EL, White K, Mehrotra R, LaPage J, Dickson P, Adler SG, Iyengar SK. Severe vascular calcification and tumoral calcinosis in a family with hyperphosphatemia: a fibroblast growth factor 23 mutation identified by exome sequencing. Nephrol Dial Transplant. 2014;29(12):2235–43. doi: 10.1093/ndt/gfu324. Epub 2014 Nov 5. CrossRefPubMedPubMedCentral
Tuy BE, John TK, Uglialoro AD, Beebe KS, Vives MJ, Patterson FR. Tumoral calcinosis presenting as neck pain and mass lesion of the cervical spine. Am J Orthop (Belle Mead, NJ). 2008;37(11):E191–5.
Watanabe A, Isoe S, Kaneko M, Nukui H. Tumoral calcinosis of the lumbar meninges: case report. Neurosurgery. 2000;47(1):230–2. PubMed
Cofan F, Garcia S, Combalia A, Campistol JM, Oppenheimer F, Ramón R. Uremic tumoral calcinosis in patients receiving longterm hemodialysis therapy. J Rheumatol. 1999;26(2):379–85. PubMed
Sunder S, Verma H, Venkataramanan K. Cervical tumoral calcinosis with secondary hyperparathyroidism in a chronic hemodialysis patient. Hemodial Int. 2013;17:441–62. CrossRef
- Tumoral calcinosis in the cervical spine: a case report and review of the literature
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