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Journal of Natural Medicines
Erschienen in: Journal of Natural Medicines 3/2018

26.02.2018 | Note

Two flavonol glycosides from Liparis bootanensis

verfasst von: Shuai Huang, Run Wu, Feng Gao, Chunying Li, Xianli Zhou

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2018

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Abstract

Two new flavonol glycosides, bootanenside I and II (1 and 2), along with ten known compounds (3–12), were isolated from whole plant of Liparis bootanensis Griff. Their structures were elucidated on the basis of extensive spectroscopic analyses, including high-resolution electrospray-ionization mass spectrometry (HR–ESIMS) and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR). The cytotoxicity of the compounds was investigated against HCT116 human cancer cell line, revealing that none of them possessed considerable cytotoxic activity. Bioassays of the new metabolites showed that compounds 1 and 2 displayed moderate in vitro antiinflammatory activity by inhibiting expression of inducible nitric oxide synthase (iNOS) protein in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
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Metadaten
Titel
Two flavonol glycosides from Liparis bootanensis
verfasst von
Shuai Huang
Run Wu
Feng Gao
Chunying Li
Xianli Zhou
Publikationsdatum
26.02.2018
Verlag
Springer Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 3/2018
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-018-1189-7

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