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Erschienen in:

04.01.2022 | Note

Two new ɑ-pyrone derivatives from the endophytic Diaporthe sp. ECN371

verfasst von: Ken-ichi Nakashima, Yuka Higuchi, Junko Tomida, Yoshiaki Kawamura, Makoto Inoue

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2022

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Abstract

Diaportholides A (1) and B (2), two polyketides with ɑ-pyrone moieties, were isolated from the cultures of an endophytic Diaporthe sp. ECN371 isolated from Orixa japonica, together with four known polyketides, phomopsolide B (3), phomopsolidones A (4) and B (5), and 5-[(1R)-1-hydroxyethyl]-γ-oxo-2-furanbutanoic acid (6). The structures of 1 and 2 were determined by extensive analysis of NMR and MS spectroscopic data. Furthermore, the structure of 2 was confirmed by analyzing the single-crystal X-ray diffraction data. The luciferase reporter gene assay revealed that among all isolated compounds (1–6), 3, a known ɑ-pyrone derivative, exhibited agonistic activity against the peroxisome proliferator-activated receptor ɑ, which is an important regulator of lipid metabolism in humans.

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Literatur
11.
Metadaten
Titel
Two new ɑ-pyrone derivatives from the endophytic Diaporthe sp. ECN371
verfasst von
Ken-ichi Nakashima
Yuka Higuchi
Junko Tomida
Yoshiaki Kawamura
Makoto Inoue
Publikationsdatum
04.01.2022
Verlag
Springer Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 2/2022
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-021-01586-y