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Journal of Natural Medicines

Erschienen in:

12.10.2017 | Note

Two new cytotoxic stilbenoid dimers isolated from Cajanus cajan

verfasst von: Nenling Zhang, Xiangchun Shen, Xiaofei Jiang, Jiazhong Cai, Xiaoling Shen, Yingjie Hu, Samuel X. Qiu

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2018

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Abstract

Two new stilbenoid dimers, cajanstilbenoids A (1) and B (2), were isolated from the leaves of Cajanus cajan. Planar structures of these compounds were verified by NMR (1D and 2D) and high-resolution electrospray ionization mass spectroscopy (HR-ESI–MS). Absolute configurations were assigned by comparing experimental and calculated electronic CD values. The cytotoxicity of 1 and 2 against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7), and human lung cancer (A549) cells were evaluated in vitro. Compound 1 showed strong cytotoxicity against all the tested cell lines (IC₅₀ values: 2.14–2.56 µM), whereas compound 2 showed strong toxicity only against HepG2 (IC₅₀ value: 5.99 µM) and A549 cells (IC₅₀ value: 6.18 µM).

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Titel: Two new cytotoxic stilbenoid dimers isolated from Cajanus cajan
verfasst von: Nenling Zhang
Xiangchun Shen
Xiaofei Jiang
Jiazhong Cai
Xiaoling Shen
Yingjie Hu
Samuel X. Qiu
Publikationsdatum: 12.10.2017
Verlag: Springer Singapore
Erschienen in: Journal of Natural Medicines / Ausgabe 1/2018
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-017-1138-x

Springer Medizin

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