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31.08.2018 | Note | Ausgabe 1/2019 Open Access

Journal of Natural Medicines 1/2019

Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana

Journal of Natural Medicines > Ausgabe 1/2019
Sutin Kaennakam, Kamonwan Mudsing, Kitiya Rassamee, Pongpun Siripong, Santi Tip-pyang
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Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s11418-018-1240-8) contains supplementary material, which is available to authorized users.


Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (38) and anthraquinones (910) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2). Compounds 36 and 8 showed good cytotoxicity against all the five cancer cell lines with IC50 values in the range of 1.45–9.46 µM.

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