Only a limited number of multiple synchronous primary malignancies of the pancreas have been reported in the medical literature. We report a case of two solid malignant tumors of the pancreas diagnosed preoperatively.
We describe a 65-year-old Sri Lankan woman who presented with progressive obstructive jaundice. Initial contrast-enhanced computed tomography imaging detected a malignant tumor at the tail of her pancreas. A second tumor of the pancreatic head was detected with integrated imaging using multidetector computed tomography and multimodal magnetic resonance imaging. She underwent total pancreaticoduodenectomy and splenectomy. Gross examination of the specimen confirmed the presence of two separate tumors. Histology of the ampullary tumor showed pancreatic-type adenocarcinoma and the tumor in the tail of her pancreas showed a colloid-type adenocarcinoma.
The possibility of multiple primary malignant solid tumors of different types with malignant potential has to be considered even without background pathology when managing multiple tumors in the pancreas.
Koji Y, u S, Hatori T, et al. Pancreatic Ductal Adenocarcinoma Derived From IPMN and Pancreatic Ductal Adenocarcinoma Concomitant with IPMN. Pancreas. 2011;40(4):571–80. CrossRef
Lin F, Wang HL. Chapter 25: Pancreas and ampulla. Tables 25.1 and 25.6. In: Lin F, Prichard J, editors. Handbook of Practical Immunohistochemistry, vol. 2. New York: Springer-Verlag; 2015. p. 482–8. ISBN 978-1-4939-1577-4.
- Two synchronous malignant tumors of the pancreas: a case report
W. S. L. De Silva
A. A. Pathirana
S. A. P. D. Rajapakse
P. S. H. Hettiarachchi
D. S. Manawasinghe
B. K. Dassanayake
- BioMed Central