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Erschienen in: Discover Oncology 3/2018

09.03.2018 | Original Paper

Type 1 IGF Receptor Localization in Paediatric Gliomas: Significant Association with WHO Grading and Clinical Outcome

verfasst von: Florencia Clément, Ayelen Martin, Marcela Venara, Maria de Luján Calcagno, Cecilia Mathó, Silvana Maglio, Mercedes García Lombardi, Ignacio Bergadá, Patricia A Pennisi

Erschienen in: Discover Oncology | Ausgabe 3/2018

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Abstract

Nuclear localization of insulin-like growth factor receptor type 1 (IGF-1R) has been described as adverse prognostic factor in some cancers. We studied the expression and localization of IGF-1R in paediatric patients with gliomas, as well as its association with World Health Organization (WHO) grading and survival. We conducted a single cohort, prospective study of paediatric patients with gliomas. Samples were taken at the time of the initial surgery; IGF-1R expression and localization were characterized by immunohistochemistry (IHC), subcellular fractionation and western blotting. Tumours (47/53) showed positive staining for IGF-1R by IHC. IGF-1R nuclear labelling was observed in 10/47 cases. IGF-1R staining was mostly non-nuclear in low-grade tumours, while IGF-1R nuclear labelling was predominant in high-grade gliomas (p = 0.0001). Survival was significantly longer in patients with gliomas having non-nuclear IGF-1R localization than in patients with nuclear IGF-1R tumours (p = 0.016). In gliomas, IGF-1R nuclear localization was significantly associated with both high-grade tumours and increased risk of death. Based on a prospective design, we provide evidence of a potential usefulness of intracellular localization of IGF-1R as prognostic factor in paediatric patients with gliomas.
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Zurück zum Zitat F. Clément, M. Venara, S. Maglio, A. Martin, C. Matho, C. Petre, M. García Lombardi, I. Bergadá and Pennisi. 2015. Characterization of IGF-1 receptor expression and localization in paediatric tumours of the central nervous system upon diagnosis according to WHO 2007 grading. Endocrine Reviews (36) 2, Suppl F. Clément, M. Venara, S. Maglio, A. Martin, C. Matho, C. Petre, M. García Lombardi, I. Bergadá and Pennisi. 2015. Characterization of IGF-1 receptor expression and localization in paediatric tumours of the central nervous system upon diagnosis according to WHO 2007 grading. Endocrine Reviews (36) 2, Suppl
Metadaten
Titel
Type 1 IGF Receptor Localization in Paediatric Gliomas: Significant Association with WHO Grading and Clinical Outcome
verfasst von
Florencia Clément
Ayelen Martin
Marcela Venara
Maria de Luján Calcagno
Cecilia Mathó
Silvana Maglio
Mercedes García Lombardi
Ignacio Bergadá
Patricia A Pennisi
Publikationsdatum
09.03.2018
Verlag
Springer US
Erschienen in
Discover Oncology / Ausgabe 3/2018
Print ISSN: 1868-8497
Elektronische ISSN: 2730-6011
DOI
https://doi.org/10.1007/s12672-018-0328-7

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