nach oben

Erschienen in:

28.01.2020 | Brief Article

Type of Anaesthetic Influences [¹¹C]MDL100,907 Binding to 5HT_2A Receptors in Porcine Brain

verfasst von: Anne M. Landau, Ove Noer, Aage Kristian Olsen Alstrup, Hélène Audrain, Gregers Wegener, Albert Gjedde, Doris J. Doudet, Michael Winterdahl

Erschienen in: Molecular Imaging and Biology | Ausgabe 4/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Anaesthesia routinely is used in animal neuroimaging in order to reduce head motion artefacts and minimize the influence of stress. However, anaesthetics can modify radioligand binding profiles at receptor targets studied by positron emission tomography (PET). Here, we determined the effects of two routine anaesthetics on the binding of a tracer of the serotonin 5HT_2A receptors.

Procedures

Isoflurane- and propofol-anesthetised Göttingen minipigs were imaged with [¹¹C]MDL100,907 PET and analysed using regions of interest and statistical non-parametric mapping.

Results

The binding potentials of the tracer in striatum under isoflurane anaesthesia significantly exceeded those obtained under propofol anaesthesia, an effect we attribute to the higher blood flow in brain induced by the former.

Conclusions

Interactions between radioligands and anaesthesia must be carefully evaluated in the design of in vivo neuroimaging and interpretation of data.

Waaben J, Husum B, Hansen AJ, Gjedde A (1989) Hypocapnia prevents the decrease in regional cerebral metabolism during isoflurane-induced hypotension. J Neurosurg Anesthesiol 1:29–34CrossRef

Ferris CF, Febo M, Luo F, Schmidt K, Brevard M, Harder JA, Kulkarni P, Messenger T, King JA (2006) Functional magnetic resonance imaging in conscious animals: a new tool in behavioural neuroscience research. J Neuroendocrinol 18:307–318CrossRef

Tsukada H, Miyasato K, Kakiuchi T, Nishiyama S, Harada N, Domino EF (2002) Comparative effects of methamphetamine and nicotine on the striatal [(11)C]raclopride binding in unanesthetized monkeys. Synapse 45:207–212CrossRef

Alstrup AK, Smith DF (2013) Anaesthesia for positron emission tomography scanning of animal brains. Lab Anim 47:12–18CrossRef

Tsukada H, Nishiyama S, Kakiuchi T et al (1999) Isoflurane anesthesia enhances the inhibitory effects of cocaine and GBR12909 on dopamine transporter: PET studies in combination with microdialysis in the monkey brain. Brain Res 849:85–96CrossRef

Hassoun W, Le Cavorsin M, Ginovart N et al (2003) PET study of the [11C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow. Eur J Nucl Med Mol Imaging 30:141–148CrossRef

Alstrup AKO, Simonsen M, Landau AM (2011) Type of anesthesia influences positron emission tomography measurements of dopamine D-2/3 receptor binding in the rat brains. Scand J Lab Anim Sci 38:195–200

Pedersen K, Simonsen M, Ostergaard SD et al (2007) Mapping the amphetamine-evoked changes in [11C]raclopride binding in living rat using small animal PET: modulation by MAO-inhibition. NeuroImage 35:38–46CrossRef

Alstrup AK, Landau AM, Holden JE et al (2013) Effects of anesthesia and species on the uptake or binding of radioligands in vivo in the Gottingen minipig. Biomed Res Int 2013:808713CrossRef

10.

Landau AM, Alstrup AK, Audrain H et al (2018) Elevated dopamine D1 receptor availability in striatum of Gottingen minipigs after electroconvulsive therapy. J Cereb Blood Flow Metab 38(5):881–887

11.

Landau AM, Dyve S, Jakobsen S, Alstrup AK, Gjedde A, Doudet DJ (2015) Acute vagal nerve stimulation lowers alpha2 adrenoceptor availability: possible mechanism of therapeutic action. Brain stimul 8:702–707CrossRef

12.

Landau AM, Alstrup AKO, Noer O et al (2019) Electroconvulsive stimulation differentially affects [(11)C]MDL100,907 binding to cortical and subcortical 5HT2A receptors in porcine brain. J Psychopharmacol 33(6):714–721

13.

Winterdahl M, Noer O, Orlowski D et al (2019) Sucrose intake lowers mu-opioid and dopamine D2/3 receptor availability in porcine brain. Sci Rep 9:16918CrossRef

14.

Watanabe H, Andersen F, Simonsen CZ, Evans SM, Gjedde A, Cumming P (2001) MR-based statistical atlas of the Gottingen minipig brain. NeuroImage 14:1089–1096CrossRef

15.

Ichise M, Toyama H, Innis RB, Carson RE (2002) Strategies to improve neuroreceptor parameter estimation by linear regression analysis. J Cereb Blood Flow Metab 22:1271–1281CrossRef

16.

Ikemoto K, Nishimura A, Okado N, Mikuni M, Nishi K, Nagatsu I (2000) Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration. Brain Res 853:377–380CrossRef

17.

Yokoyama C, Yamanaka H, Onoe K, Kawasaki A, Nagata H, Shirakami K, Doi H, Onoe H (2010) Mapping of serotonin transporters by positron emission tomography with [11C] DASB in conscious common marmosets: comparison with rhesus monkeys. Synapse 64:594–601CrossRef

18.

Yokoyama C, Mawatari A, Kawasaki A et al (2016) Marmoset serotonin 5-HT1A receptor mapping with a biased agonist PET probe 18F-F13714: comparison with an antagonist tracer 18F-MPPF in awake and anesthetized states. Int J Neuropsychopharmacol 19(12). https://doi.org/10.1093/ijnp/pyw079

19.

Tokugawa J, Ravasi L, Nakayama T, Lang L, Schmidt KC, Seidel J, Green MV, Sokoloff L, Eckelman WC (2007) Distribution of the 5-HT(1A) receptor antagonist [ (18)F] FPWAY in blood and brain of the rat with and without isoflurane anesthesia. Eur J Nucl Med Mol Imaging 34:259–266CrossRef

20.

Mukaida K, Shichino T, Koyanagi S, Himukashi S, Fukuda K (2007) Activity of the serotonergic system during isoflurane anesthesia. Anesth Analg 104:836–839CrossRef

21.

Whittington RA, Virag L (2006) Isoflurane decreases extracellular serotonin in the mouse hippocampus. Anesth Analg 103:92–98 table of contentsCrossRef

22.

Johansen SL, Iceman KE, Iceman CR, Taylor BE, Harris MB (2015) Isoflurane causes concentration-dependent inhibition of medullary raphe 5-HT neurons in situ. Auton Neurosci 193:51–56CrossRef

23.

Elfving B, Bjornholm B, Knudsen GM (2003) Interference of anaesthetics with radioligand binding in neuroreceptor studies. Eur J Nucl Med Mol Imaging 30:912–915CrossRef

24.

Laruelle M (2000) Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. J Cereb Blood Flow Metab 20:423–451CrossRef

25.

Kobayashi K, Inoue O, Watanabe Y, Onoe H, Langstrom B (1995) Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anesthetics in rhesus monkey brain. J Neural Transm Gen Sect 100:147–151CrossRef

26.

Schlunzen L, Vafaee MS, Cold GE, Rasmussen M, Nielsen JF, Gjedde A (2004) Effects of subanaesthetic and anaesthetic doses of sevoflurane on regional cerebral blood flow in healthy volunteers. A positron emission tomographic study. Acta Anaesthesiol Scand 48:1268–1276CrossRef

27.

Gjedde A, Johannsen P, Cold GE, Ostergaard L (2005) Cerebral metabolic response to low blood flow: possible role of cytochrome oxidase inhibition. J Cereb Blood Flow Metab 25:1183–1196CrossRef

28.

Fiset P, Paus T, Daloze T et al (1999) Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study. J Neurosci 19:5506–5513CrossRef

29.

Kaisti KK, Langsjo JW, Aalto S et al (2003) Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 99:603–613CrossRef

30.

Lagerkranser M, Stange K, Sollevi A (1997) Effects of propofol on cerebral blood flow, metabolism, and cerebral autoregulation in the anesthetized pig. J Neurosurg Anesthesiol 9:188–193CrossRef

31.

Enlund M, Andersson J, Hartvig P, Valtysson J, Wiklund L (1997) Cerebral normoxia in the rhesus monkey during isoflurane- or propofol-induced hypotension and hypocapnia, despite disparate blood-flow patterns. A positron emission tomography study. Acta Anaesthesiol Scand 41:1002–1010CrossRef

32.

Kuroda Y, Murakami M, Tsuruta J, Murakawa T, Sakabe T (1996) Preservation of the ration of cerebral blood flow/metabolic rate for oxygen during prolonged anesthesia with isoflurane, sevoflurane, and halothane in humans. Anesthesiology 84:555–561CrossRef

33.

Kapur S, Seeman P (2002) NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2)receptors-implications for models of schizophrenia. Mol Psychiatry 7:837–844CrossRef

Titel: Type of Anaesthetic Influences [11C]MDL100,907 Binding to 5HT2A Receptors in Porcine Brain
verfasst von: Anne M. Landau
Ove Noer
Aage Kristian Olsen Alstrup
Hélène Audrain
Gregers Wegener
Albert Gjedde
Doris J. Doudet
Michael Winterdahl
Publikationsdatum: 28.01.2020
Verlag: Springer International Publishing
Erschienen in: Molecular Imaging and Biology / Ausgabe 4/2020
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-020-01476-x

Neu im Fachgebiet Radiologie

23.04.2024 | Pankreaskarzinom | Nachrichten

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Type of Anaesthetic Influences [¹¹C]MDL100,907 Binding to 5HT_2A Receptors in Porcine Brain

Abstract

Purpose

Procedures

Results

Conclusions

Neu im Fachgebiet Radiologie

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Radiologie

Springer Medizin

Abstract

Purpose

Procedures

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2020

Glutamate-Weighted CEST Contrast After Removal of Magnetization Transfer Effect in Human Brain and Rat Brain with Tumor

A Pretargeted Imaging Strategy for Immune Checkpoint Ligand PD-L1 Expression in Tumor Based on Bioorthogonal Diels-Alder Click Chemistry

Preclinical Evaluation and Dosimetry of [111In]CHX-DTPA-scFv78-Fc Targeting Endosialin/Tumor Endothelial Marker 1 (TEM1)

Next-Generation Radiogenomics Sequencing for Prediction of EGFR and KRAS Mutation Status in NSCLC Patients Using Multimodal Imaging and Machine Learning Algorithms

Application of [68Ga]PSMA PET/CT in Diagnosis and Management of Prostate Cancer Patients

Magnetic Particle Imaging of Macrophages Associated with Cancer: Filling the Voids Left by Iron-Based Magnetic Resonance Imaging

Neu im Fachgebiet Radiologie

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

„Nur wer sich gut aufgehoben fühlt, kann auch für Patientensicherheit sorgen“

Wie toxische Männlichkeit der Gesundheit von Männern schadet

Update Radiologie