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Breast Cancer Research
Erschienen in: Breast Cancer Research 3/2000

01.06.2000 | Review

Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases

verfasst von: David F Stern

Erschienen in: Breast Cancer Research | Ausgabe 3/2000

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Abstract

ERBB family receptor tyrosine kinases are overexpressed in a significant subset of breast cancers. One of these receptors, HER2/neu, or ErbB-2, is the target for a new rational therapeutic antibody, Herceptin. Other inhibitors that target this receptor, and another family member, the epidermal growth factor (EGF) receptor, are moving into clinical trials. Both of these receptors are sometimes overexpressed in breast cancer, and still subject to regulation by hormones and other physiological regulators. Optimal use of therapeutics targeting these receptors will require consideration of the several modes of regulation of these receptors and their interactions with steroid receptors.
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Metadaten
Titel
Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
verfasst von
David F Stern
Publikationsdatum
01.06.2000
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 3/2000
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr51

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