Skip to main content
Erschienen in: Pneumo News 4/2021

10.09.2021 | NSCLC | CME Fortbildung

Neuerungen in der thorakalen Onkologie

NSCLC und SCLC

verfasst von: Priv.-Doz. Dr. med. Niels Reinmuth, Martina Merk, Thomas Duell

Erschienen in: Pneumo News | Ausgabe 4/2021

Einloggen, um Zugang zu erhalten

Auszug

Mit der Entdeckung der therapeutischen Relevanz von Checkpointinhibitoren hat sich die Therapie insbesondere des nichtkleinzelligen Lungenkarzinoms (NSCLC) erheblich verändert. Eine Untergruppe der NSCLC ist durch die Detektion spezifischer molekularer Veränderungen charakterisiert, die in vielen Fällen gezielte Therapieansätze erlauben. Auch in frühen Therapiestadien und beim kleinzelligen Lungenkarzinom (SCLC) werden aktuell neue Behandlungsansätze klinisch evaluiert.
Literatur
1.
Zurück zum Zitat Reinmuth N. Lungenkrebsscreening - wer, wo und wie? Dtsch Med Wochenschr. 2019;144:1721-5 Reinmuth N. Lungenkrebsscreening - wer, wo und wie? Dtsch Med Wochenschr. 2019;144:1721-5
2.
Zurück zum Zitat Aberle DR, Adams AM, Berg CD et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365:395-409 Aberle DR, Adams AM, Berg CD et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med. 2011;365:395-409
3.
Zurück zum Zitat National Lung Screening Trial Research Team. Lung Cancer Incidence and Mortality with Extended Follow-up in the National Lung Screening Trial. J Thorac Oncol. 2019;14:1732-42 National Lung Screening Trial Research Team. Lung Cancer Incidence and Mortality with Extended Follow-up in the National Lung Screening Trial. J Thorac Oncol. 2019;14:1732-42
4.
Zurück zum Zitat De Koning HJ, Van Der Aalst CM, De Jong PA et al. Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial. N Engl J Med. 2020;382:503-13 De Koning HJ, Van Der Aalst CM, De Jong PA et al. Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial. N Engl J Med. 2020;382:503-13
5.
Zurück zum Zitat Becker N, Motsch E, Trotter A et al. Lung cancer mortality reduction by LDCT screening-Results from the randomized German LUSI trial. Int J Cancer. 2020;146(6):1503-13 Becker N, Motsch E, Trotter A et al. Lung cancer mortality reduction by LDCT screening-Results from the randomized German LUSI trial. Int J Cancer. 2020;146(6):1503-13
6.
Zurück zum Zitat Reinmuth N, Schumann C. [Fundamental Changes in the Treatment of Lung Cancer]. Pneumologie. 2018;72:732-5 Reinmuth N, Schumann C. [Fundamental Changes in the Treatment of Lung Cancer]. Pneumologie. 2018;72:732-5
7.
Zurück zum Zitat Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. Nature. 2018;553:446-54 Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. Nature. 2018;553:446-54
8.
Zurück zum Zitat Griesinger F, Eberhardt W, Früh M et al. Lungenkarzinom, nicht-kleinzellig (NSCLC). Onkopedia. 2021; https://www.onkopedia.com/de/onkopedia/guidelines/lungenkarzinom-nicht-kleinzellig-nsclc/@@guideline/html/index.html; zugegriffen am 25.5.2021 Griesinger F, Eberhardt W, Früh M et al. Lungenkarzinom, nicht-kleinzellig (NSCLC). Onkopedia. 2021; https://​www.​onkopedia.​com/​de/​onkopedia/​guidelines/​lungenkarzinom-nicht-kleinzellig-nsclc/​@@guideline/html/index.html; zugegriffen am 25.5.2021
9.
Zurück zum Zitat Planchard D, Popat S, Kerr K et al. Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29 Suppl 4:iv192-iv237 Planchard D, Popat S, Kerr K et al. Metastatic non-small cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018;29 Suppl 4:iv192-iv237
10.
Zurück zum Zitat Ramalingam SS, Vansteenkiste J, Planchard D et al. Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC. N Engl J Med. 2020;382(1):41-50 Ramalingam SS, Vansteenkiste J, Planchard D et al. Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC. N Engl J Med. 2020;382(1):41-50
11.
Zurück zum Zitat Shaw AT, Yeap BY, Mino-Kenudson M et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009;27:4247-53 Shaw AT, Yeap BY, Mino-Kenudson M et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol. 2009;27:4247-53
12.
Zurück zum Zitat Camidge R, Kim HR, Ahn M et al. Brigatinib vs crizotinib in patients with ALK inhibitor-naive advanced ALK+ NSCLC: Updated results from the phase III ALTA-1L trial. Annals of Oncology. 2019; https://doi.org/10.1093/annonc/mdz446 Camidge R, Kim HR, Ahn M et al. Brigatinib vs crizotinib in patients with ALK inhibitor-naive advanced ALK+ NSCLC: Updated results from the phase III ALTA-1L trial. Annals of Oncology. 2019; https://​doi.​org/​10.​1093/​annonc/​mdz446
13.
Zurück zum Zitat Peters S, Camidge DR, Shaw AT et al. Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer. N Engl J Med. 2017;377(9):829-38 Peters S, Camidge DR, Shaw AT et al. Alectinib versus Crizotinib in Untreated ALK-Positive Non-Small-Cell Lung Cancer. N Engl J Med. 2017;377(9):829-38
14.
Zurück zum Zitat Shaw AT, Solomon BJ. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med. 2015;372:683-4 Shaw AT, Solomon BJ. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med. 2015;372:683-4
15.
Zurück zum Zitat Planchard D, Besse B, Groen HJM et al. Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial. Lancet Oncol. 2016;17:984-93 Planchard D, Besse B, Groen HJM et al. Dabrafenib plus trametinib in patients with previously treated BRAF(V600E)-mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial. Lancet Oncol. 2016;17:984-93
16.
Zurück zum Zitat Drilon A, Laetsch TW, Kummar S et al. Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children. N Engl J Med. 2018;378:731-9 Drilon A, Laetsch TW, Kummar S et al. Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children. N Engl J Med. 2018;378:731-9
17.
Zurück zum Zitat Reinmuth N, Merk M, Duell T. Immuntherapie des nichtkleinzelligen Lungenkarzinoms. Onkologe. 2021;27:179-90 Reinmuth N, Merk M, Duell T. Immuntherapie des nichtkleinzelligen Lungenkarzinoms. Onkologe. 2021;27:179-90
18.
Zurück zum Zitat Reck M, Rodriguez-Abreu D, Robinson AG et al. Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50 % or Greater. J Clin Oncol. 2019;37:537-46 Reck M, Rodriguez-Abreu D, Robinson AG et al. Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50 % or Greater. J Clin Oncol. 2019;37:537-46
19.
Zurück zum Zitat Brahmer JR, Rodriguez-Abreu D, Robinson AG et al. KEYNOTE-024 5-year OS update: First-line (1L) pembrolizumab (pembro) vs platinum-based chemotherapy (chemo) in patients (pts) with metastatic NSCLC and PD-L1 tumour proportion score (TPS) ≥50 %. Ann Oncol. 2020;31:S1142-S1215; Abstract LBA1151 Brahmer JR, Rodriguez-Abreu D, Robinson AG et al. KEYNOTE-024 5-year OS update: First-line (1L) pembrolizumab (pembro) vs platinum-based chemotherapy (chemo) in patients (pts) with metastatic NSCLC and PD-L1 tumour proportion score (TPS) ≥50 %. Ann Oncol. 2020;31:S1142-S1215; Abstract LBA1151
20.
Zurück zum Zitat Spigel D, De Marinis F, Giaccone G et al. IMpower110: Interim overall survival (OS) analysis of a phase III study of atezolizumab (atezo) vs platinum-based chemotherapy (chemo) as first-line (1L) treatment (tx) in PD-L1-selected NSCLC. Ann Oncol. 2019;30(Suppl 5):v915 Spigel D, De Marinis F, Giaccone G et al. IMpower110: Interim overall survival (OS) analysis of a phase III study of atezolizumab (atezo) vs platinum-based chemotherapy (chemo) as first-line (1L) treatment (tx) in PD-L1-selected NSCLC. Ann Oncol. 2019;30(Suppl 5):v915
21.
Zurück zum Zitat Sezer A, Kilickap S, Gümüş M et al. LBA52: EMPOWER-Lung 1: Phase III first-line (1L) cemiplimab monotherapy vs platinum-doublet chemotherapy (chemo) in advanced non-small cell lung cancer (NSCLC) with programmed cell death-ligand 1 (PD-L1) ≥50 %. Ann Oncol. 2020;31(Suppl 4):S1142-S1215; https://doi.org/10.1016/j.annonc.2020.08.2285 Sezer A, Kilickap S, Gümüş M et al. LBA52: EMPOWER-Lung 1: Phase III first-line (1L) cemiplimab monotherapy vs platinum-doublet chemotherapy (chemo) in advanced non-small cell lung cancer (NSCLC) with programmed cell death-ligand 1 (PD-L1) ≥50 %. Ann Oncol. 2020;31(Suppl 4):S1142-S1215; https://​doi.​org/​10.​1016/​j.​annonc.​2020.​08.​2285
22.
Zurück zum Zitat Gandhi L, Rodriguez-Abreu D, Gadgeel S et al. Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378:2078-92 Gandhi L, Rodriguez-Abreu D, Gadgeel S et al. Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378:2078-92
23.
Zurück zum Zitat Socinski MA, Jotte RM, Cappuzzo F et al. Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC. N Engl J Med. 2018;378:2288-301 Socinski MA, Jotte RM, Cappuzzo F et al. Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC. N Engl J Med. 2018;378:2288-301
24.
Zurück zum Zitat Jotte R, Cappuzzo F, Vynnychenko I et al. Atezolizumab in Combination With Carboplatin and Nab-Paclitaxel in Advanced Squamous NSCLC (IMpower131): Results From a Randomized Phase III Trial. J Thorac Oncol. 2020;15:1351-60 Jotte R, Cappuzzo F, Vynnychenko I et al. Atezolizumab in Combination With Carboplatin and Nab-Paclitaxel in Advanced Squamous NSCLC (IMpower131): Results From a Randomized Phase III Trial. J Thorac Oncol. 2020;15:1351-60
25.
Zurück zum Zitat West H, Mccleod M, Hussein M et al. Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2019;20:924-37 West H, Mccleod M, Hussein M et al. Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2019;20:924-37
26.
Zurück zum Zitat Paz-Ares L, Luft A, Vicente D et al. Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer. N Engl J Med. 2018;379:2040-51 Paz-Ares L, Luft A, Vicente D et al. Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer. N Engl J Med. 2018;379:2040-51
27.
Zurück zum Zitat Reck M, Ciuleanu TE, Dols MC et al. Nivolumab (NIVO) + ipilimumab (IPI) + 2 cycles of platinum-doublet chemotherapy (chemo) vs 4 cycles chemo as first-line (1L) treatment (tx) for stage IV/recurrent non-small cell lung cancer (NSCLC): CheckMate 9LA. J Clin Oncol. 2020;38:abstr 9501 Reck M, Ciuleanu TE, Dols MC et al. Nivolumab (NIVO) + ipilimumab (IPI) + 2 cycles of platinum-doublet chemotherapy (chemo) vs 4 cycles chemo as first-line (1L) treatment (tx) for stage IV/recurrent non-small cell lung cancer (NSCLC): CheckMate 9LA. J Clin Oncol. 2020;38:abstr 9501
28.
Zurück zum Zitat Leighl NB, Laurie SA, Goss GD et al. CCTG BR.34: A randomized trial of durvalumab and tremelimumab +/- platinum-based chemotherapy in patients with metastatic (Stage IV) squamous or nonsquamous non-small cell lung cancer (NSCLC). J Clin Oncol. 2020;38:abstr 9502 Leighl NB, Laurie SA, Goss GD et al. CCTG BR.34: A randomized trial of durvalumab and tremelimumab +/- platinum-based chemotherapy in patients with metastatic (Stage IV) squamous or nonsquamous non-small cell lung cancer (NSCLC). J Clin Oncol. 2020;38:abstr 9502
29.
Zurück zum Zitat Martins F, Sofiya L, Sykiotis GP et al. Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance. Nat Rev Clin Oncol 16:563-580 Martins F, Sofiya L, Sykiotis GP et al. Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance. Nat Rev Clin Oncol 16:563-580
30.
Zurück zum Zitat Antonia SJ, Villegas A, Daniel D et al. (2018) Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC. N Engl J Med. 2019;379:2342-50 Antonia SJ, Villegas A, Daniel D et al. (2018) Overall Survival with Durvalumab after Chemoradiotherapy in Stage III NSCLC. N Engl J Med. 2019;379:2342-50
31.
Zurück zum Zitat Faivre-Finn C, Vicente D, Kurata T et al. Durvalumab after chemoradiotherapy in stage III NSCLC: 4-year survival update from the phase III PACIFIC trial. Ann Oncol. 2020;31:S1142-S1215. Abstract LBA1149 Faivre-Finn C, Vicente D, Kurata T et al. Durvalumab after chemoradiotherapy in stage III NSCLC: 4-year survival update from the phase III PACIFIC trial. Ann Oncol. 2020;31:S1142-S1215. Abstract LBA1149
32.
Zurück zum Zitat Forde PM, Chaft JE, Smith KN et al. Neoadjuvant PD-1 Blockade in Resectable Lung Cancer. N Engl J Med. 2018;378:1976-86 Forde PM, Chaft JE, Smith KN et al. Neoadjuvant PD-1 Blockade in Resectable Lung Cancer. N Engl J Med. 2018;378:1976-86
33.
Zurück zum Zitat Wakelee HA, Altorki NK, Zhou C et al. IMpower010: Primary results of a phase III global study of atezolizumab versus best supportive care after adjuvant chemotherapy in resected stage IB-IIIA non-small cell lung cancer (NSCLC). J Clin Oncol. 2021;39:abstr 8500 Wakelee HA, Altorki NK, Zhou C et al. IMpower010: Primary results of a phase III global study of atezolizumab versus best supportive care after adjuvant chemotherapy in resected stage IB-IIIA non-small cell lung cancer (NSCLC). J Clin Oncol. 2021;39:abstr 8500
34.
Zurück zum Zitat Wu YL, Tsuboi M, He J et al. Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer. N Engl J Med. 2020;383:1711-23 Wu YL, Tsuboi M, He J et al. Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer. N Engl J Med. 2020;383:1711-23
35.
Zurück zum Zitat Horn L, Mansfield AS, Szczesna A et al. First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer. N Engl J Med. 2018;379:2220-9 Horn L, Mansfield AS, Szczesna A et al. First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer. N Engl J Med. 2018;379:2220-9
36.
Zurück zum Zitat Paz-Ares L, Dvorkin M, Chen Y et al. Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial. Lancet. 2019;394:1929-39 Paz-Ares L, Dvorkin M, Chen Y et al. Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial. Lancet. 2019;394:1929-39
37.
Zurück zum Zitat Von Pawel J, Jotte R, Spigel DR et al. Randomized phase III trial of amrubicin versus topotecan as second-line treatment for patients with small-cell lung cancer. J Clin Oncol. 2014;32:4012-9 Von Pawel J, Jotte R, Spigel DR et al. Randomized phase III trial of amrubicin versus topotecan as second-line treatment for patients with small-cell lung cancer. J Clin Oncol. 2014;32:4012-9
38.
Zurück zum Zitat Trigo J, Subbiah V, Besse B et al. Lurbinectedin as second-line treatment for patients with small-cell lung cancer: a single-arm, open-label, phase 2 basket trial. Lancet Oncol. 2020;21:645-54 Trigo J, Subbiah V, Besse B et al. Lurbinectedin as second-line treatment for patients with small-cell lung cancer: a single-arm, open-label, phase 2 basket trial. Lancet Oncol. 2020;21:645-54
Metadaten
Titel
Neuerungen in der thorakalen Onkologie
NSCLC und SCLC
verfasst von
Priv.-Doz. Dr. med. Niels Reinmuth
Martina Merk
Thomas Duell
Publikationsdatum
10.09.2021
Verlag
Springer Medizin
Erschienen in
Pneumo News / Ausgabe 4/2021
Print ISSN: 1865-5467
Elektronische ISSN: 2199-3866
DOI
https://doi.org/10.1007/s15033-021-2728-6

Weitere Artikel der Ausgabe 4/2021

Pneumo News 4/2021 Zur Ausgabe