Skip to main content
Erschienen in: Tumor Biology 11/2016

12.09.2016 | Original Article

U/G SNP rs111904020 in 3′UTR of STAT3 regulated by miR-214 promotes hepatocellular carcinoma development in Chinese population

verfasst von: Ye Fan, Xiaofeng Qian, Chuanyong Zhang

Erschienen in: Tumor Biology | Ausgabe 11/2016

Einloggen, um Zugang zu erhalten

Abstract

STAT3 is an oncogene which mainly capable of regulating various biological characters by its transcriptional factor features driving thousands of genes. However, its upstream noncoding RNA-related regulations still remain unknown. In this study, we focused on the microRNA (miRNA)-associated single nucleotide polymorphisms (SNPs) in the 3′ unstranslated region (UTR) of STAT3 to investigate the further relationship of the SNPs with miRNAs among Chinese patients with hepatocellular carcinoma (HCC). We found that patients suffering from HBV infection indicated to be the susceptible population by comparing with controls. Besides, SNP rs111904020 (U/G) in STAT3, 3′UTR was involved in the occurrence of HCC by acting as tumor promoter factors. SNP rs111904020 (U/G) could be regulated by miR-214 which caused an upregulation of STAT3. Furthermore, the carriers of G genotype was related to high expression of STAT3, and larger tumor size as well as high probability of metastasis. Moreover, the SNP of U/G was associated with poor survival and high reoccurrence of HCC with a 5-year follow-up study. In conclusion, our findings have shown that the SNP rs111904020 (U/G) in STAT3 3′UTR acted as promotion factors in the HCC development through disrupting the regulatory role of miR-214 in STAT3 expression.
Literatur
3.
Zurück zum Zitat Banerjee K, Resat H. Constitutive activation of STAT3 in breast cancer cells: a review. International journal of cancer Journal international du cancer. 2015. doi:10.1002/ijc.29923. Banerjee K, Resat H. Constitutive activation of STAT3 in breast cancer cells: a review. International journal of cancer Journal international du cancer. 2015. doi:10.​1002/​ijc.​29923.
5.
10.
Zurück zum Zitat Zhang Y, Wei W, Cheng N, Wang K, Li B, Jiang X, et al. Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling. Hepatology. 2012;56(5):1631–40. doi:10.1002/hep.25849.CrossRefPubMed Zhang Y, Wei W, Cheng N, Wang K, Li B, Jiang X, et al. Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling. Hepatology. 2012;56(5):1631–40. doi:10.​1002/​hep.​25849.CrossRefPubMed
11.
Zurück zum Zitat Wang B, Hsu SH, Majumder S, Kutay H, Huang W, Jacob ST, et al. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene. 2010;29(12):1787–97. doi:10.1038/onc.2009.468.CrossRefPubMed Wang B, Hsu SH, Majumder S, Kutay H, Huang W, Jacob ST, et al. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene. 2010;29(12):1787–97. doi:10.​1038/​onc.​2009.​468.CrossRefPubMed
12.
Zurück zum Zitat Sentinelli F, Filippi E, Fallarino M, Romeo S, Fanelli M, Buzzetti R, et al. The 3′-UTR C>T polymorphism of the oxidized LDL-receptor 1 (OLR1) gene does not associate with coronary artery disease in Italian CAD patients or with the severity of coronary disease. Nutrition, metabolism, and cardiovascular diseases: NMCD. 2006;16(5):345–52. doi:10.1016/j.numecd.2005.06.002.CrossRefPubMed Sentinelli F, Filippi E, Fallarino M, Romeo S, Fanelli M, Buzzetti R, et al. The 3′-UTR C>T polymorphism of the oxidized LDL-receptor 1 (OLR1) gene does not associate with coronary artery disease in Italian CAD patients or with the severity of coronary disease. Nutrition, metabolism, and cardiovascular diseases: NMCD. 2006;16(5):345–52. doi:10.​1016/​j.​numecd.​2005.​06.​002.CrossRefPubMed
14.
Zurück zum Zitat GoDarts, Group UDPS, Wellcome Trust Case Control C, Zhou K, Bellenguez C, Spencer CC, et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet. 2011;43(2):117–20. doi:10.1038/ng.735.CrossRef GoDarts, Group UDPS, Wellcome Trust Case Control C, Zhou K, Bellenguez C, Spencer CC, et al. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet. 2011;43(2):117–20. doi:10.​1038/​ng.​735.CrossRef
16.
20.
Zurück zum Zitat Deguchi A. Curcumin targets in inflammation and cancer. Endocrine, metabolic & immune disorders drug targets. 2015;15(2):88–96.CrossRef Deguchi A. Curcumin targets in inflammation and cancer. Endocrine, metabolic & immune disorders drug targets. 2015;15(2):88–96.CrossRef
21.
Zurück zum Zitat Rybak AP, Bristow RG, Kapoor A. Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression. Oncotarget. 2015;6(4):1900–19.CrossRefPubMed Rybak AP, Bristow RG, Kapoor A. Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression. Oncotarget. 2015;6(4):1900–19.CrossRefPubMed
22.
Zurück zum Zitat Shih TC, Tien YJ, Wen CJ, Yeh TS, Yu MC, Huang CH, et al. MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. J Hepatol. 2012;57(3):584–91. doi:10.1016/j.jhep.2012.04.031.CrossRefPubMed Shih TC, Tien YJ, Wen CJ, Yeh TS, Yu MC, Huang CH, et al. MicroRNA-214 downregulation contributes to tumor angiogenesis by inducing secretion of the hepatoma-derived growth factor in human hepatoma. J Hepatol. 2012;57(3):584–91. doi:10.​1016/​j.​jhep.​2012.​04.​031.CrossRefPubMed
Metadaten
Titel
U/G SNP rs111904020 in 3′UTR of STAT3 regulated by miR-214 promotes hepatocellular carcinoma development in Chinese population
verfasst von
Ye Fan
Xiaofeng Qian
Chuanyong Zhang
Publikationsdatum
12.09.2016
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 11/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-016-5352-z

Weitere Artikel der Ausgabe 11/2016

Tumor Biology 11/2016 Zur Ausgabe

Update Onkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.