Skip to main content
Erschienen in: Der Orthopäde 7/2005

01.07.2005 | Leitthema

Übergewicht und Arthrose

verfasst von: A.-F. Groß, S. Fickert, Prof. Dr. K. P. Günther

Erschienen in: Die Orthopädie | Ausgabe 7/2005

Einloggen, um Zugang zu erhalten

Zusammenfassung

Immer mehr Menschen erkranken an einer Osteoarthrose der unterschiedlichen Gelenke. Daraus ergeben sich vielfältige sozioökonomische Probleme.
In verschiedenen epidemiologischen Studien konnte ein Zusammenhang zwischen Gon- bzw. Koxarthrosen und Übergewicht aufgezeigt werden. Die genauen Entstehungsmechanismen der Arthrose sind in diesen Fällen noch unklar, jedoch ist ein multifaktorielles Geschehen zu vermuten: Neben einer im Vordergrund stehenden erhöhten mechanischen Belastung, die zur Knorpelschädigung führt, kann auch ein metabolischer Effekt über biochemische Faktoren wirksam sein. Die Kenntnis der unterschiedlichen Entstehungsmechanismen könnte Ansätze für künftige therapeutische Möglichkeiten bieten.
Literatur
1.
Zurück zum Zitat Anderson JJ, Felson DT (1988) Factors associated with osteoarthritis of the knee in the first national Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work. Am J Epidemiol 128: 179–189PubMed Anderson JJ, Felson DT (1988) Factors associated with osteoarthritis of the knee in the first national Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work. Am J Epidemiol 128: 179–189PubMed
2.
Zurück zum Zitat Bagge E, Bjelle A, Eden S, Svanborg A (1991) Factors associated with radiographic osteoarthritis: results from the population study 70-year-old people in Goteborg. J Rheumatol 18: 1218–1222PubMed Bagge E, Bjelle A, Eden S, Svanborg A (1991) Factors associated with radiographic osteoarthritis: results from the population study 70-year-old people in Goteborg. J Rheumatol 18: 1218–1222PubMed
3.
Zurück zum Zitat Coggon D, Reading I, Croft P, McLaren M, Barrett D, Cooper C (2001) Knee osteoarthritis and obesity. Int J Obes Relat Metab Disord 25: 622–627CrossRefPubMed Coggon D, Reading I, Croft P, McLaren M, Barrett D, Cooper C (2001) Knee osteoarthritis and obesity. Int J Obes Relat Metab Disord 25: 622–627CrossRefPubMed
4.
Zurück zum Zitat Davis MA, Ettinger WH, Neuhaus JM (1990) Obesity and osteoarthritis of the knee: evidence from the National Health and Nutrition Examination Survey (NHANES I). Semin Arthritis Rheum 20: 34–41CrossRefPubMed Davis MA, Ettinger WH, Neuhaus JM (1990) Obesity and osteoarthritis of the knee: evidence from the National Health and Nutrition Examination Survey (NHANES I). Semin Arthritis Rheum 20: 34–41CrossRefPubMed
5.
Zurück zum Zitat Felson DT (1996) Does excess weight cause osteoarthritis and, if so, why? Ann Rheum Dis 55: 668–670PubMed Felson DT (1996) Does excess weight cause osteoarthritis and, if so, why? Ann Rheum Dis 55: 668–670PubMed
6.
Zurück zum Zitat Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF (1988) Obesity and knee osteoarthritis. The Framingham Study. Ann Intern Med 109: 18–24PubMed Felson DT, Anderson JJ, Naimark A, Walker AM, Meenan RF (1988) Obesity and knee osteoarthritis. The Framingham Study. Ann Intern Med 109: 18–24PubMed
7.
Zurück zum Zitat Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ (1992) Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med 116: 535–539PubMed Felson DT, Zhang Y, Anthony JM, Naimark A, Anderson JJ (1992) Weight loss reduces the risk for symptomatic knee osteoarthritis in women. The Framingham Study. Ann Intern Med 116: 535–539PubMed
8.
Zurück zum Zitat Felson DT, Zhang Y, Hannan MT, Naimark A, Weissman B, Aliabadi P, Levy D (1997) Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum 40: 728–733PubMed Felson DT, Zhang Y, Hannan MT, Naimark A, Weissman B, Aliabadi P, Levy D (1997) Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum 40: 728–733PubMed
9.
Zurück zum Zitat Gunther KP, Scharf HP, Puhl W (1997) Standardization of roentgen diagnosis in coxarthrosis and gonarthrosis in clinical studies. Recommendations of the 1st Working Circle of the DGOT (Connective Tissue Research and Arthrosis Deformans). Z Orthop Ihre Grenzgeb 135: 193–196PubMed Gunther KP, Scharf HP, Puhl W (1997) Standardization of roentgen diagnosis in coxarthrosis and gonarthrosis in clinical studies. Recommendations of the 1st Working Circle of the DGOT (Connective Tissue Research and Arthrosis Deformans). Z Orthop Ihre Grenzgeb 135: 193–196PubMed
10.
Zurück zum Zitat Gunther KP, Scharf HP, Puhl W, Willauschus W, Kalke Y, Glückert K, Sun Y (1997) Reproduzierbarkeit der radiologischen Diagnostik bei Gonarthrose. Z Orthop 135: 197–202PubMed Gunther KP, Scharf HP, Puhl W, Willauschus W, Kalke Y, Glückert K, Sun Y (1997) Reproduzierbarkeit der radiologischen Diagnostik bei Gonarthrose. Z Orthop 135: 197–202PubMed
11.
Zurück zum Zitat Gunther KP, Sturmer T, Sauerland S et al. (1998) Prevalence of generalised osteoarthritis in patients with advanced hip and knee osteoarthritis: the Ulm Osteoarthritis Study. Ann Rheum Dis 57: 717–723PubMed Gunther KP, Sturmer T, Sauerland S et al. (1998) Prevalence of generalised osteoarthritis in patients with advanced hip and knee osteoarthritis: the Ulm Osteoarthritis Study. Ann Rheum Dis 57: 717–723PubMed
12.
Zurück zum Zitat Gunther KP, Sturmer T, Trepte CT, Naumann T, Kinzl L, Puhl W (1999) Incidence of joint-specific risk factors in patients with advanced cox- and gonarthroses in the Ulm Osteoarthrosis Study. Z Orthop Ihre Grenzgeb 137: 468–473PubMed Gunther KP, Sturmer T, Trepte CT, Naumann T, Kinzl L, Puhl W (1999) Incidence of joint-specific risk factors in patients with advanced cox- and gonarthroses in the Ulm Osteoarthrosis Study. Z Orthop Ihre Grenzgeb 137: 468–473PubMed
13.
Zurück zum Zitat Hart DJ, Spector TD (1993) The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. J Rheumatol 20: 331–335PubMed Hart DJ, Spector TD (1993) The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. J Rheumatol 20: 331–335PubMed
14.
Zurück zum Zitat Hochberg MC, Lethbridge-Cejku M, Scott WW Jr, Reichle R, Plato CC, Tobin JD (1995) The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol 22: 488–493PubMed Hochberg MC, Lethbridge-Cejku M, Scott WW Jr, Reichle R, Plato CC, Tobin JD (1995) The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol 22: 488–493PubMed
15.
Zurück zum Zitat Kiess W, Gausche R, Keller A, Burmeister J, Willgerodt H, Keller E (2001) Computer-guided, population-based screening system for growth disorders (CrescNet) and on-line generation of normative data for growth and development. Horm Res 56 [Suppl 1]: 59–66CrossRefPubMed Kiess W, Gausche R, Keller A, Burmeister J, Willgerodt H, Keller E (2001) Computer-guided, population-based screening system for growth disorders (CrescNet) and on-line generation of normative data for growth and development. Horm Res 56 [Suppl 1]: 59–66CrossRefPubMed
16.
Zurück zum Zitat Korsten-Reck U, Kromeyer-Hauschild K, Wolfarth B, Dickhuth HH, Berg A (2005) Freiburg Intervention trial for obese children (FITOC): results of a clinical observation study. Int J Obes Relat Metab Disord 29: 356–361PubMed Korsten-Reck U, Kromeyer-Hauschild K, Wolfarth B, Dickhuth HH, Berg A (2005) Freiburg Intervention trial for obese children (FITOC): results of a clinical observation study. Int J Obes Relat Metab Disord 29: 356–361PubMed
17.
Zurück zum Zitat Kromeyer-Hauschild K, Zellner K, Jaeger U, Hoyer H (1999) Prevalence of overweight and obesity among school children in Jena (Germany). Int J Obes Relat Metab Disord 23: 1143–1150PubMed Kromeyer-Hauschild K, Zellner K, Jaeger U, Hoyer H (1999) Prevalence of overweight and obesity among school children in Jena (Germany). Int J Obes Relat Metab Disord 23: 1143–1150PubMed
18.
Zurück zum Zitat Lievense AM, Bierma-Zeinstra SM, Verhagen AP, van Baar ME, Verhaar JA, Koes BW (2002) Influence of obesity on the development of osteoarthritis of the hip: a systematic review. Rheumatology (Oxford) 41: 1155–1162 Lievense AM, Bierma-Zeinstra SM, Verhagen AP, van Baar ME, Verhaar JA, Koes BW (2002) Influence of obesity on the development of osteoarthritis of the hip: a systematic review. Rheumatology (Oxford) 41: 1155–1162
19.
Zurück zum Zitat Manninen P, Riihimak H, Heliovaara M (1995) Incidence and risk factors of low-back pain in middle-aged farmers. Occup Med (Lond) 45: 141–146 Manninen P, Riihimak H, Heliovaara M (1995) Incidence and risk factors of low-back pain in middle-aged farmers. Occup Med (Lond) 45: 141–146
20.
Zurück zum Zitat Manninen P, Riihimaki H, Heliovaara M, Suomalainen O (2004) Weight changes and the risk of knee osteoarthritis requiring arthroplasty. Ann Rheum Dis 63: 1434–147PubMed Manninen P, Riihimaki H, Heliovaara M, Suomalainen O (2004) Weight changes and the risk of knee osteoarthritis requiring arthroplasty. Ann Rheum Dis 63: 1434–147PubMed
21.
Zurück zum Zitat Maquet P, Van De Berg A, Simonet J (1976) The weight-bearing surfaces of the femoro-tibial joint. Acta Orthop Belg 42 [Suppl 1]: 139–143 Maquet P, Van De Berg A, Simonet J (1976) The weight-bearing surfaces of the femoro-tibial joint. Acta Orthop Belg 42 [Suppl 1]: 139–143
22.
Zurück zum Zitat Marks R, Allegrante JP (2002) Body mass indices in patients with disabling hip osteoarthritis. Arthritis Res 4: 112–116CrossRefPubMed Marks R, Allegrante JP (2002) Body mass indices in patients with disabling hip osteoarthritis. Arthritis Res 4: 112–116CrossRefPubMed
23.
Zurück zum Zitat McGoey BV, Deitel M, Saplys RJ, Kliman ME (1990) Effect of weight loss on musculoskeletal pain in the morbidly obese. J Bone Joint Surg Br 72: 322–323PubMed McGoey BV, Deitel M, Saplys RJ, Kliman ME (1990) Effect of weight loss on musculoskeletal pain in the morbidly obese. J Bone Joint Surg Br 72: 322–323PubMed
24.
Zurück zum Zitat Mehrotra C, Naimi TS, Serdula M, Bolen J, Pearson K (2004) Arthritis, body mass index, and professional advice to lose weight: implications for clinical medicine and public health. Am J Prev Med 27: 16–21PubMed Mehrotra C, Naimi TS, Serdula M, Bolen J, Pearson K (2004) Arthritis, body mass index, and professional advice to lose weight: implications for clinical medicine and public health. Am J Prev Med 27: 16–21PubMed
25.
Zurück zum Zitat Miller GD, Rejeski WJ, Williamson JD et al. (2003) The arthritis, diet and activity promotion trial (ADAPT): design, rationale, and baseline results. Control Clin Trials 24: 462–480CrossRefPubMed Miller GD, Rejeski WJ, Williamson JD et al. (2003) The arthritis, diet and activity promotion trial (ADAPT): design, rationale, and baseline results. Control Clin Trials 24: 462–480CrossRefPubMed
26.
Zurück zum Zitat Morrill AC, Chinn CD (2004) The obesity epidemic in the United States. J Public Health Policy 25: 353–366PubMed Morrill AC, Chinn CD (2004) The obesity epidemic in the United States. J Public Health Policy 25: 353–366PubMed
27.
Zurück zum Zitat Oliveria SA, Felson DT, Cirillo PA, Reed JI, Walker AM (1999) Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology 10: 161–166PubMed Oliveria SA, Felson DT, Cirillo PA, Reed JI, Walker AM (1999) Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology 10: 161–166PubMed
28.
Zurück zum Zitat Pauwels F (1976) Developmental effects of the functional adaptation of bone. Anat Anz 139: 213–220PubMed Pauwels F (1976) Developmental effects of the functional adaptation of bone. Anat Anz 139: 213–220PubMed
29.
Zurück zum Zitat Petersson IF (1996) Occurrence of osteoarthritis of the peripheral joints in European populations. Ann Rheum Dis 55: 659–661PubMed Petersson IF (1996) Occurrence of osteoarthritis of the peripheral joints in European populations. Ann Rheum Dis 55: 659–661PubMed
30.
Zurück zum Zitat Schouten JS, van den Ouweland FA, Valkenburg HA (1992) A 12 year follow up study in the general population on prognostic factors of cartilage loss in osteoarthritis of the knee. Ann Rheum Dis 51: 932–937PubMed Schouten JS, van den Ouweland FA, Valkenburg HA (1992) A 12 year follow up study in the general population on prognostic factors of cartilage loss in osteoarthritis of the knee. Ann Rheum Dis 51: 932–937PubMed
31.
Zurück zum Zitat Sturmer T, Sun Y, Sauerland S, Zeissig I, Gunther KP, Puhl W, Brenner H (1998) Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study. J Rheumatol 25: 1827–1832PubMed Sturmer T, Sun Y, Sauerland S, Zeissig I, Gunther KP, Puhl W, Brenner H (1998) Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study. J Rheumatol 25: 1827–1832PubMed
32.
Zurück zum Zitat Sturmer T, Brenner H, Brenner RE, Gunther KP (2001) Non-insulin dependent diabetes mellitus (NIDDM) and patterns of osteoarthritis. The Ulm osteoarthritis study. Scand J Rheumatol 30: 169–171PubMed Sturmer T, Brenner H, Brenner RE, Gunther KP (2001) Non-insulin dependent diabetes mellitus (NIDDM) and patterns of osteoarthritis. The Ulm osteoarthritis study. Scand J Rheumatol 30: 169–171PubMed
33.
Zurück zum Zitat Sun Y, Brenner H, Sauerland S, Gunther KP, Puhl W, Sturmer T (2000) Serum uric acid and patterns of radiographic osteoarthritis — the Ulm Osteoarthritis Study. Scand J Rheumatol 29: 380–386PubMed Sun Y, Brenner H, Sauerland S, Gunther KP, Puhl W, Sturmer T (2000) Serum uric acid and patterns of radiographic osteoarthritis — the Ulm Osteoarthritis Study. Scand J Rheumatol 29: 380–386PubMed
34.
Zurück zum Zitat Sun Y, Sturmer T, Gunther KP, Brenner H (1997) Incidence and prevalence of cox- and gonarthrosis in the general population. Z Orthop Ihre Grenzgeb 135: 184–192PubMed Sun Y, Sturmer T, Gunther KP, Brenner H (1997) Incidence and prevalence of cox- and gonarthrosis in the general population. Z Orthop Ihre Grenzgeb 135: 184–192PubMed
35.
Zurück zum Zitat Tepper S, Hochberg MC (1993) Factors associated with hip osteoarthritis: data from the First National Health and Nutrition Examination Survey (NHANES-I). Am J Epidemiol 137: 1081–1088PubMed Tepper S, Hochberg MC (1993) Factors associated with hip osteoarthritis: data from the First National Health and Nutrition Examination Survey (NHANES-I). Am J Epidemiol 137: 1081–1088PubMed
36.
Zurück zum Zitat Vingard E, Alfredsson L, Malchau H (1997) Lifestyle factors and hip arthrosis. A case referent study of body mass index, smoking and hormone therapy in 503 Swedish women. Acta Orthop Scand 68: 216–220PubMed Vingard E, Alfredsson L, Malchau H (1997) Lifestyle factors and hip arthrosis. A case referent study of body mass index, smoking and hormone therapy in 503 Swedish women. Acta Orthop Scand 68: 216–220PubMed
37.
Zurück zum Zitat Zhang Y, Niu J, Kelly-Hayes M, Chaisson CE, Aliabadi P, Felson DT (2002) Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: The Framingham Study. Am J Epidemiol 156: 1021–1027CrossRefPubMed Zhang Y, Niu J, Kelly-Hayes M, Chaisson CE, Aliabadi P, Felson DT (2002) Prevalence of symptomatic hand osteoarthritis and its impact on functional status among the elderly: The Framingham Study. Am J Epidemiol 156: 1021–1027CrossRefPubMed
Metadaten
Titel
Übergewicht und Arthrose
verfasst von
A.-F. Groß
S. Fickert
Prof. Dr. K. P. Günther
Publikationsdatum
01.07.2005
Verlag
Springer-Verlag
Erschienen in
Die Orthopädie / Ausgabe 7/2005
Print ISSN: 2731-7145
Elektronische ISSN: 2731-7153
DOI
https://doi.org/10.1007/s00132-005-0814-9

Weitere Artikel der Ausgabe 7/2005

Der Orthopäde 7/2005 Zur Ausgabe

Leitthema

Achillodynie

Einführung zum Thema

Die Last mit den Pfunden

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.