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Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging 8/2019

01.05.2019 | Original Article

Ultrafast bone scintigraphy scan for detecting bone metastasis using a CZT whole-body gamma camera

verfasst von: Tomohiko Yamane, Atsushi Kondo, Masafumi Takahashi, Yuuki Miyazaki, Toshihiko Ehara, Kenji Koga, Ichiei Kuji, Ichiro Matsunari

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 8/2019

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Abstract

Purpose

To evaluate the feasibility of short whole-body bone scan acquisition times using a novel gamma camera with cadmium-zinc-telluride (CZT) semiconductor detectors.

Methods

We retrospectively enrolled 78 consecutive patients with prostate cancer who underwent bone scintigraphy using a whole-body gamma camera with CZT detectors. After acquisition of list-mode data with 180 s per bed position, anterior and posterior whole-body images were reconstructed using the first 5%, 10%, 25%, 50%, 75% and 100% of the list-mode data. Two experienced nuclear medicine physicians interpreted the images, and interrater agreement and the diagnostic value of the images were determined. Quantitative artificial neural network (ANN) values, bone scan indexes (BSI) and hotspot numbers (HsN) were also calculated by automated diagnostic software.

Results

Excellent interrater reliabilities of the visual assessments were obtained for the 100%, 75%, 50%, and 25% images (κ = 0.88, 0.88, 0.88 and 0.88, respectively). The 5% images also showed high diagnostic value (sensitivity 0.94, specificity 0.84 and accuracy 0.86). Intraclass correlation coefficients (ICC) between the 100% images and the reduced acquisition time images were evaluated in quantitative analyses, and excellent correlations were observed for ANN value in the 75% images (ICC 0.77), for BSI in all the reduced acquisition time images (75%, 50%, 25%, 10% and 5%; ICC 0.99, 0.99, 0.99, 0.96 and 0.75, respectively), and for HsN in the 75%, 50%, 25% and 10% images (ICC 0.99, 0.99, 0.98 and 0.90, respectively).

Conclusion

Whole-body gamma cameras with CZT detectors have the potential to reduce image acquisition times and the dose of radioisotope injected for bone scans.
Literatur
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Metadaten
Titel
Ultrafast bone scintigraphy scan for detecting bone metastasis using a CZT whole-body gamma camera
verfasst von
Tomohiko Yamane
Atsushi Kondo
Masafumi Takahashi
Yuuki Miyazaki
Toshihiko Ehara
Kenji Koga
Ichiei Kuji
Ichiro Matsunari
Publikationsdatum
01.05.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 8/2019
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI
https://doi.org/10.1007/s00259-019-04329-0

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