Background
Methods
Study design and setting
Intervention
Measurements
Statistics
Results
Phase I
Variables | All (n = 28) | LT (n = 19) | NL (n = 9) |
p-value |
---|---|---|---|---|
Men, % | 57 | 42 | 89 | 0.04 |
Age, years | 64 [53–74] | 60 [49–70] | 69 [55–78] | 0.29 |
Years on HD | 3 [1–6] | 3 [1–7] | 3 [1–5] | 0.94 |
Remaining diuresis, l/24 h | 0.2 [0–0.5] | 0.3 [0–0.6] | 0.2 [0–0.4] | 0.60 |
Weight, kg | 78 [67–87] | 73 [66–79] | 85 [88–92] | 0.03 |
BMI, kg/m2 | 26 [24–28] | 27 [23–30] | 26 [25–28] | 0.94 |
UF volume, l | 2.3 [1.3–3.2] | 2.6 [1.6–3.3] | 1.7 [1.2–2.1] | 0.10 |
Cause of ESRD, % | ||||
Diabetes | 32 | 21 | 56 | |
Hypertension | 18 | 26 | 0 | |
ADPKD | 7 | 5 | 11 | 0.27 |
ATN | 14 | 16 | 11 | |
Miscellaneous | 29 | 32 | 22 | |
Drugs, % | ||||
ß-blocker | 61 | 42 | 67 | 1.0 |
ACE inhibitor | 61 | 74 | 33 | 0.1 |
Calcium antagonist | 47 | 58 | 22 | 0.09 |
Variables | Baseline | Post HD/UF |
p-value |
---|---|---|---|
Mean arterial pressure, mmHg | 93 [76–111] | 96 [84–110] | 0.39 |
Heartrate, beats/min | 69 [62–80] | 73 [60–84] | 0.24 |
SpO2, % | 97 [96–98] | 98 [98–99] | 0.009 |
MFI, AU | 3 [2.8–3] | 3 [2.8–3] | 0.55 |
TVD, mm/mm2
| 22.2 [18–29.8] | 22.7 [19.9–29] | 0.11 |
PPV, % | 98 [96–100] | 98 [96–99] | 0.35 |
Phase II
Variables | Baseline | Post-intervention |
p-value |
---|---|---|---|
UF isolated | |||
UF | - | 1.7 [1.2–2] | |
UF rate, l/h | - | 1.7 [1.2–2]†
| |
MFI, AU | 2.8 [2.5–2.9] | 2.5 [2.2–2.8] | 0.03 |
TVD, mm/mm2
| 17.7 [16.5–18.4] | 18.7 [16.1–20.3] | 0.26 |
Hematocrit, % | 37 [35–39] | 39 [36–44] | 0.11 |
NT-pro-BNP, pmol/l | 599 [215–1702] | 580 [158–1440] | 0.01 |
Troponine T, ng/l | 90 [60–150] | 87 [56–130] | 0.08 |
BCM overhydration, l | 1.4 [0.6–3.2] | 0.3 [−0.1–0.8] | 0.02 |
HD isolated | |||
UF | – | 0 [0–0] | |
UF rate, l/h | – | 0 [0–0]†
| |
MFI, AU | 2.8 [2.5–2.9] | 2.8 [2.7–2.9] | 0.61 |
TVD, mm/mm2
| 17.7 [16.5–18.4] | 18.6 [14.6–19.7] | 0.86 |
Hematocrit, % | 37 [35–39] | NA | |
NT-pro-BNP, pmol/l | 599 [215–1702] | NA | |
Troponine T, ng/l | 90 [60–150] | NA | |
BCM overhydration, l | 1.4 [0.6–3.2] | NA | |
HD + linear UF | |||
UF | 1.7 [1.2–2.1] | ||
UF rate, l/h | 0.42 [0.3–5.1]†
| ||
MFI, AU | 2.9 [2.5–3] | 2.6 [2.2–2.9] | 0.12 |
TVD, mm/mm2
| 17.8 [16.6–18.8] | 19.8 [17.9–21.5] | 0.07 |
Hematocrit, % | 38 [35–40] | 40 [35–41] | 0.18 |
T-pro-BNP, pmol/l | 618 [279–1926] | 536 [167–1003] | 0.01 |
Troponine T, ng/l | 94 [61–179] | 84 [62–139] | 0.02 |
BCM overhydration, l | 1.8 [0.5–5.3] | 0.3 [−0.9–3.2] | 0.02 |
HD + BVM-guided UF | |||
UF | 2.0 [1.5–2.1] | ||
UF rate, l/h | 0.5 [0.39–0.52]†
| ||
MFI, AU | 2.8 [2.5–3] | 2.8 [1.9–2.9] | 0.06 |
TVD, mm/mm2
| 18.8 [16.8–20.6] | 18.2 [16.9–20.6] | 0.77 |
Hematocrit, % | 37 [34–39] | 39 [35–42] | 0.12 |
NT-pro-BNP, pmol/l | 574 [229–2011] | 511 [172–1163] | 0.01 |
Troponine T, ng/l | 81 [54–379] | 79 [54–387] | 0.12 |
BCM overhydration, l | 2.4 [1.5–5.1] | 0.2 [−0.9–4.2] | 0.04 |