Background
Methods
Research targets and grouping
Instruments and methods
Liver Elastography ultrasound
Quantitative measurement of the common carotid artery
Clinical information
Statistical analysis
Results
General clinical data of the subjects
Control Group n = 64 | Patients with chronic viral hepatitis | F |
P
| ||
---|---|---|---|---|---|
Patients with CHB n = 147 | Patients with CHC n = 70 | ||||
Age, Years | 45.8 ± 10.6 | 46.5 ± 12.2 | 47.6 ± 12.1 | 0.400 | 0.670 |
Men Percentage, Count (%) | 43(67) | 98(67) | 47(67) | – | – |
Systolic pressure, mmHg | 115.7 ± 11.6 | 116.2 ± 13.1 | 119.7 ± 12.8 | 2.166 | 0.177 |
Diastolic, pressure mmHg | 71.2 ± 8.7 | 73.2 ± 8.6 | 71.2 ± 8.6 | 1.872 | 0.156 |
Blood Glu, mmol/L | 4.9 ± 0.5 | 5.3 ± 1.1 | 6.0 ± 1.7 | 15.933 | < 0.001 |
Glycated haemoglobin, % | 5.3 ± 0.5 | 5.5 ± 1.4 | 6.8 ± 1.6 | 30.804 | < 0.001 |
BMI, Kg/m2 | 23.2 ± 2.6 | 23.5 ± 3.0 | 24.4 ± 3.4 | 2.936 | 0.055 |
Cholesterol, mmol/L | 3.8 ± 1.1 | 3.8 ± 1.3 | 3.7 ± 1.1 | 0.373 | 0.689 |
Triglycerides, mmol/L | 1.2 ± 0.7 | 1.2 ± 0.5 | 1.2 ± 0.6 | 0.185 | 0.831 |
LDL, mmol/L | 1.9 ± 0.8 | 1.8 ± 0.8 | 1.7 ± 0.8 | 0.695 | 0.500 |
HDL, mmol/L | 1.0 ± 0.3 | 1.2 ± 0.4 | 1.1 ± 0.5 | 3.115 | 0.046* |
Platelets, 109 /L | 187.6 ± 70.2 | 137.4 ± 77.8 | 138.3 ± 64.3 | 11.598 | < 0.001 |
AST, U/L | 23.8 ± 8.7 | 45.8 ± 34.2 | 37.7 ± 24.6 | 13.927 | < 0.001 |
ALT, U/L | 28.5 ± 13.8 | 46.1 ± 38.5 | 43.1 ± 40.4 | 5.765 | 0.004 |
Albumin, g/L | 43.8 ± 7.4 | 40.9 ± 8.9 | 40.8 ± 8.2 | 3.104 | 0.046* |
Globulin, g/L | 24.2 ± 6.3 | 25.3 ± 7.2 | 24.9 ± 7.1 | 0.566 | 0.569 |
Comparison of liver stiffness and elasticity parameters among groups
Comparison of liver stiffness and left common carotid elasticity parameters among different age groups
Age, Year | No. | ARFI, m/s | IMT, μm | PWV, m/s | DC, 1/kPa | |
---|---|---|---|---|---|---|
Control Group | < 50 | 41 | 1.02 ± 0.09 | 478.44 ± 107.86 | 5.72 ± 0.73 | 0.035 ± 0.007 |
≥50 | 23 | 1.06 ± 0.13 | 633.26 ± 120.02 | 6.75 ± 0.80 | 0.026 ± 0.007 | |
P
| – | 0.127 | < 0.001* | < 0.001* | < 0.001* | |
CHB Group | < 50 | 86 | 1.72 ± 0.50 | 456.70 ± 87.56 | 6.26 ± 1.35 | 0.038 ± 0.062 |
≥50 | 61 | 2.02 ± 0.50 | 630.30 ± 112.17 | 7.32 ± 1.00 | 0.020 ± 0.007 | |
P
| – | < 0.001* | < 0.001* | < 0.001* | 0.009* | |
CHC Group | < 50 | 41 | 1.84 ± 0.38 | 526.63 ± 130.03 | 7.70 ± 1.57 | 0.018 ± 0.009 |
≥50 | 29 | 1.89 ± 0.36 | 673.17 ± 167.48 | 8.36 ± 1.09 | 0.015 ± 0.006 | |
P
| – | 0.569 | < 0.001* | 0.041* | 0.079 |
Age, Year | No. | CC, mm2/kPa | α | β | Aix,% | |
---|---|---|---|---|---|---|
Control Group | < 50 | 41 | 1.376 ± 0.259 | 2.70 ± 0.54 | 5.54 ± 1.10 | 0.82 ± 5.18 |
≥50 | 23 | 1.137 ± 0.129 | 3.63 ± 0.81 | 7.30 ± 1.70 | 3.14 ± 4.76 | |
P
| – | < 0.001* | < 0.001* | < 0.001* | 0.082 | |
CHB Group | < 50 | 86 | 1.139 ± 0.420 | 3.71 ± 1.69 | 7.58 ± 3.41 | 1.55 ± 4.41 |
≥50 | 61 | 0.935 ± 0.291 | 4.72 ± 1.51 | 9.61 ± 2.96 | 5.25 ± 4.68 | |
P
| – | 0.001* | < 0.001* | < 0.001* | < 0.001* | |
CHC Group | < 50 | 41 | 0.854 ± 0.423 | 5.31 ± 1.97 | 10.65 ± 3.79 | 1.75 ± 3.45 |
≥50 | 29 | 0.761 ± 0.303 | 6.42 ± 2.57 | 13.11 ± 5.13 | 4.84 ± 3.75 | |
P
| – | 0.317 | 0.044* | 0.024* | 0.001* |