Background
Methods
Patients
Nutritional support
Ultrasonography of skeletal muscles
Statistical analysis
Results
ALL | SF n 20 | HPF n 18 | |
---|---|---|---|
Female sex, n (%) | 9 (24) | 5 (25) | 4 (22) |
Age (years) | 40 [31–54] | 47 [37–58] | 37 [29–46] |
Height (cm) | 175 [167–180] | 175 [168–180] | 170 [167–180] |
Weight (k) | 75 [70–81] | 80 [70–90] | 75 [67–85] |
BMI | 25 [23–28] | 26 [23–29] | 23 [24–26] |
GCS at inclusion | 7 [3–9] | 7 [3–9] | 6 [3–10] |
GCS-M at inclusion | 4 [1–5] | 4 [1–5] | 4 [1–5] |
Injury Severity Score (ISS) | 34 [27–42] | 34 [28–40] | 34 [27–45] |
Apache II score | 16 [13–20] | 16 [13–19] | 18 [12–22] |
SOFA | 7 [5–9] | 8 [5–10] | 6 [5–9] |
Brain injury n (%) | 32 (84) | 17 (85) | 15 (83) |
Thoracic trauma n (%) | 30 (79) | 16 (80) | 14 (78) |
Abdominal trauma n (%) | 17 (45) | 9 (45) | 8 (44) |
Pelvic trauma n (%) | 15 (40) | 8 (40) | 7 (40) |
Spinal trauma n (%) | 21 (55) | 10 (50) | 11 (61) |
GOS 28 days | 3 [3, 4] | 3 [3, 4] | 3 [3, 4] |
GCS-M at discharge | 6 [4–6] | 6 [5, 6] | 6 [4–6] |
Tracheostomy n (%) | 24 (63) | 12 (60) | 12 (67) |
Weaning | |||
Simple, n (%) | 21 (55) | 10 (50) | 11 (61) |
Difficult, n (%) | 11 (29) | 6 (30) | 5 (28) |
Prolonged, n (%) | 6 (16) | 4 (20) | 2 (11) |
Days of mechanical ventilation | 13 [11–19] | 14 [9–22] | 13 [11–17] |
Patients with at least one documented infection, n (%) | 34 (90) | 19 (95) | 15 (83) |
Patients with at least one documented infection MDR infection, n (%) | 23 (61) | 13 (65) | 10 (56) |
Patients with septic shock during the ICU stay, n (%) | 7 (18) | 5 (25) | 2 (11) |
ICU length of stay | 22 (17–33) | 22 (16–37) | 22 (17–31) |
ICU outcome, died, n (%) | 3 (8) | 2 (10) | 1 (6) |
Day 0 | Day 5 | Day 10 | Day 15 | Day 20 | |
---|---|---|---|---|---|
RF: AP diam (mm) | |||||
All pts | 17 [15–20] | 17 [15–20] | 16 [13–19] | 14 [12–17] | 13 [9–15] |
SF | 17 [15–20] | 18 [16–20] | 19 [14–20] | 15 [12–17] | 14 [9–17] |
HPF | 17 [15–19] | 16 [15–20] | 16 [12–18] | 13 [12–17] | 9 [9–12] |
RF: LL diam (mm) | |||||
All pts | 43 [40–46] | 41 [38–44] | 40 [37–45] | 40 [36–44] | 38 [34–41] |
SF | 41 [40–44] | 41 [37–42] | 39 [35–42] | 40 [34–44] | 35 [34–40] |
HPF | 43 [40–47] | 44 [37–46] | 44 [37–47] | 40 [37–47] | 41 [37–43] |
RF: CSA (cm2) | |||||
All pts | 6.1 [5.1–7.3] | 5.9 [4.8–6.3] | 5.1 [4.3–6.2] | 4.6 [3.8–5.3] | 3.5 [3.2–4.7] |
SF | 6.1 [5.1–7.3] | 5.9 [4.9–6.3] | 5.6 [4.2–6.2] | 4.7 [3.9–5.4] | 3.5 [3.2–4.8] |
HPF | 6.3 [4.7–7.3] | 5.9 [4.3–6.5] | 5 [4.2–6.6] | 4.4 [3.5–5.1] | 3.5 [2.8–4.4] |
RF: echogenicity, Heckmatt Scale | |||||
All pts | 1 [1, 2] | 2 [1, 2] | 2 [1–2.5] | 2 [1–3] | 2.5 [1.5–3] |
SF | 1 [1, 2] | 2 [1, 2] | 2 [1.3–2.8] | 2.3 [1.6–3.5] | 2.5 [2, 3] |
HPF | 1.3 [1, 2] | 1.5 [1, 2] | 1 [1, 2] | 1.5 [1–2.5] | 2.5 [1–3] |
AT: AP diam (mm) | |||||
All pts | 22 [20–25] | 21 [19–23] | 20 [17–22] | 19 [17–22] | 18 [16–20] |
SF | 22 [20–24] | 21 [19–24] | 20 [18–23] | 20 [17–23] | 19 [15–21] |
HPF | 24 [20–26] | 22 [19–23] | 21 [17–22] | 18 [17–20] | 18 [18] |
AT: LL diam (mm) | |||||
All pts | 25 [22–26] | 24 [21–26] | 23 [21–25] | 22 [20–25] | 22 [20–27] |
SF | 25 [23–27] | 24 [21–27] | 23 [21–26] | 23 [19–26] | 25 [21–28] |
HPF | 23 [22–26] | 24 [21–26] | 22 [21–25] | 21 [20–24] | 22 [20–22] |
AT: CSA (cm2) | |||||
All pts | 5.6 [4.5–6.4] | 4.8 [3.7–5.6] | 4 [3.7–5.2] | 4 [3.3–4.8] | 4.2 [3.4–4.7] |
SF | 5.7 [4.7–6.8] | 4 [3.6–6] | 3.9 [3.7–5.2] | 4 [3.3–5.7] | 4 [3.2–5.2] |
HPF | 5.5 [4.5–6.2] | 4.9 [4.2–5.9] | 4.2 [3.6–5.3] | 3.9 [3.3–4.5] | 4.3 [3.4–4.6] |
AT: echogenicity, Heckmatt Scale | |||||
All pts | 2 [1, 2] | 2 [1–3] | 2 [1–3] | 1.5 [1–3] | 2.5 [1–4] |
SF | 1.8 [1–2.1] | 2.3 [1.3–3] | 2 [1.3–3] | 2 [1–3.4] | 3.5 [1–4] |
HPF | 2 [1, 2] | 2 [1–3] | 1.3 [1–3] | 1.3 [1–2.5] | 1.5 [1–3] |
Day 0–5 | Day 5–10 | Day 10–15 | Day 15–20 | SF versus HPF p value | |
---|---|---|---|---|---|
Enteral nutrition (ml/day) | |||||
SF | 850 [625–900] | 1000 [1000–1400]* | 1050 [950–1500]* | 1350 [1000–1500]* | 0.007 |
HPF | 1000 [700–1200] | 1500 [1175–1500]* | 1500 [1500–1700]* | 1500 [1500–2000]* | |
Proteins (g/day) | |||||
SF | 47 [32–63]* | 67 [50–91]* | 70 [48–90]* | 70 [50–90]* | 0.001 |
HPF | 74 [40–93]* | 112 [99–136]* | 136 [112–136]* | 120 [106–136]* | |
Total calories (kcal/day) | |||||
SF | 1059 [763–1200]* | 1500 [1160–1915]* | 1500 [1050–2062]* | 1500 [1250–2200]* | 0.005 |
HPF | 1326 [934–1564]* | 1958 [1762–2250]* | 2250 [1920–2341]* | 2250 [1920–2560]* |
Day 0 | Day 5 | Day 10 | Day 15 | Day 20 | SF versus HPF p value | |
---|---|---|---|---|---|---|
BUN (mg/dl) | ||||||
SF | 12 [10–15] | 17 [13–26] | 20 [17–30] | 25 [17–35] | 24 [18–47] | 0.51 |
HPF | 13 [11–17] | 18 [12–22] | 23 [19–29] | 20 [16–24] | 30 [23–37] | |
Creatinine (mg/dl) | ||||||
SF | 0.8 [0.7–1] | 0.6 [0.5–0.8] | 0.6 [0.5–0.8] | 0.6 [0.5–0.7] | 0.6 [0.5–1.6] | 0.46 |
HPF | 1 [0.6–1.2] | 0.7 [0.5–0.8] | 0.6 [0.5–0.7] | 0.6 [0.4–0.7] | 0.7 [0.5–0.8] | |
Phosphate (mg/dl) | ||||||
SF | 2.7 [2–3.5] | 2.9 [2.3–3.4] | 3 [2.5–3.3] | 3.5 [2.7–3.8] | 3.5 [2.8–4.1] | 0.41 |
HPF | 3.1 [2.5–4] | 2.9 [2.1–3.6] | 3.5 [2.5–4] | 3.4 [2.6–4.1] | 3.6 [3.3–4] | |
Proteins (g/L) | ||||||
SF | 4.7 [3.9–6.1] | 5.2 [4.7–5.6] | 5.8 [5.2–6.3] | 6.1 [5.3–6.5] | 5.8 [5.2–6.4] | 0.07 |
HPF | 5.3 [5–5.7] | 5.4 [5, 6] | 5.8 [5.2–6.6] | 6.4 [5.7–7.3] | 7.3 [5.6–8.3] | |
Albumin (g/L) | ||||||
SF | 2.9 [2.4–3.4]* | 2.6 [2.2–2.9] | 2.6 [2.1–2.9] | 2.8 [2.3–3] | 2.5 [2.1–2.9]* | 0.03 |
HPF | 3.3 [3–3.6]* | 2.7 [2.5–3.1] | 2.7 [2.3–3.1] | 3 [2.8–3.3] | 3.1 [2.6–3.7]* |
Discussion
Quantitative changes of skeletal muscles
Qualitative changes of skeletal muscles
Grade | Ultrasound appearance |
---|---|
Grade 1 | Normal |
Grade 2 | Increased muscle echo intensity with distinct bone echo |
Grade 3 | Marked increased muscle echo intensity with a reduced bone echo |
Grade 4 | Very strong muscle echo and complete loss of bone echo |