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Erschienen in: Endocrine 3/2019

05.09.2019 | Original Article

Ultrasound combined with biochemical parameters can predict parathyroid carcinoma in patients with primary hyperparathyroidism

verfasst von: Ruifeng Liu, Yu Xia, Cheng Chen, Tiantian Ye, Xuepei Huang, Li Ma, Ya Hu, Yuxin Jiang

Erschienen in: Endocrine | Ausgabe 3/2019

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Abstract

Purposes

Parathyroid cancer (PC) is rare, but fatal condition. Preoperative prediction of PC remains challenging but meaningful. The aim of this study was to determine an effective model to predict PC in patients with parathyroid lesions >1.5 cm.

Methods

In this retrospective case-control study, we enrolled 30 patients with PC matched to 60 patients with parathyroid adenoma or hyperplasia by admission year. All patients were diagnosed with primary hyperparathyroidism (pHPT) and had parathyroid lesions >1.5 cm. Ultrasonic features of the two patient groups, as well as demographic, clinical, and biochemical characteristics were retrospectively compared. Best subset selection and multivariate logistic regression analysis were conducted to identify the independent risk factors of PC. ROC curve and decision curve analysis were developed to evaluate the applicability of the new model.

Results

The best subset selection method and multiple logistic regression analysis showed that ultrasonic features of DR (two diameters’ ratio of the lesion) and tumor infiltration in conjunction with intact parathyroid hormone (iPTH) level (collective model) were independent predictors of malignancy. Meanwhile, DR, shape, and tumor infiltration (ultrasound model) were found to be risk factors when only ultrasonic features were included in the multivariate analysis. The decision curve analysis showed that collective model outperforms ultrasound model with a better net benefit and a wider range of threshold probabilities.

Conclusions

Ultrasonic features in combination with iPTH level may be an applicable model for predicting PC and has a better potential to facilitate decision-making preoperatively.
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Metadaten
Titel
Ultrasound combined with biochemical parameters can predict parathyroid carcinoma in patients with primary hyperparathyroidism
verfasst von
Ruifeng Liu
Yu Xia
Cheng Chen
Tiantian Ye
Xuepei Huang
Li Ma
Ya Hu
Yuxin Jiang
Publikationsdatum
05.09.2019
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 3/2019
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-019-02069-7

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