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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Women's Health 1/2015

Ultrasound guided aspiration of hydrosalpinx fluid versus salpingectomy in the management of patients with ultrasound visible hydrosalpinx undergoing IVF-ET: a randomized controlled trial

Zeitschrift:
BMC Women's Health > Ausgabe 1/2015
Autoren:
Usama M Fouda, Ahmed M Sayed, Hatem I Abdelmoty, Khaled A Elsetohy
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

All the authors have made substantial contributions to conception and design, or collection of data, or analysis of data, and have been involved in drafting the manuscript or revising it critically for important intellectual content. All the authors have read and approved the final manuscript.

Authors’ information

• Usama M. Fouda, MD, PhD, Assistant Professor of Obstetrics and Gynecology, Faculty of Medicine, Cairo university, and scientific director of assisted conception unit, Aljazeera (Al Gazeera) hospital.
• Ahmed M. Sayed, MD, PhD, Assistant professor of Obstetrics and Gynecology, Faculty of medicine, Cairo university, and clinical director of assisted conception unit, Aljazeera (Al Gazeera) hospital.
• Hatem I. Abdelmoty, M.D, PhD, Assistant Professor of Obstetrics and Gynecology, Faculty of Medicine, Cairo university.
• Khaled A. Elsetohy, MD, PhD, Lecturer of Obstetrics and Gynecology, Faculty of Medicine, Cairo university.

Abstract

Background

The aim of this study was to compare the efficacy of ultrasound guided aspiration of hydrosalpinx fluid at the time of oocyte retrieval with salpingectomy in the management of patients with ultrasound visible hydrosalpinx undergoing IVF-ET.

Methods

One hundred and sixty patients with ultrasound visible hydrosalpinx were randomized into salpingectomy group and aspiration group using computer generated randomization list and sequentially numbered sealed envelopes containing allocation information written on a card.

Results

The clinical pregnancy rate per started cycle and the implantation rate were non- significantly higher in the salpingectomy group compared with the aspiration group [40% vs. 27.5% (p value = 0.132) and 18.95% vs. 12.82% (p value =0.124), respectively]. In the aspiration group, 34.21% of patients had rapid re-accumulation of the hydrosalpinx fluid (i.e. within first two weeks after embryo transfer). Whereas, the clinical pregnancy rate per transfer cycle and the implantation rate were significantly higher in salpingectomy group compared with the subgroup of patients with rapid re-accumulation of hydrosalpinx fluid [42.67% vs. 19.23% (p value = 0.036) and 18.95% vs. 7.58% (p value = 0.032), respectively], no significant differences were detected between the salpingectomy group and the subgroup of patients with no re-accumulation of hydrosalpinx fluid (42.67% vs. 34% (p value = 0.356) and 18.95% vs. 15.5% (p value = 0.457), respectively).

Conclusion

The small sample size could be the cause of failure of detecting significant increase in implantation and pregnancy rates in salpingectomy group compared with aspiration group. Further larger randomized controlled trials are needed to determine whether salpingectomy is more effective than aspiration of hydrosalpinx fluid or not. Moreover, the data presented in this study suggested that rapid re-accumulation of hydrosalpinx fluid is an obstacle against successful implantation and the cause of lower success rate with ultrasound guided aspiration of hydrosalpinx fluid compared with salpingectomy.

Trial registration

Clinical trials.gov (NCT02008240), registered 8 December 2013.
Literatur
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