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Erschienen in: Archives of Dermatological Research 6/2018

17.05.2018 | Concise Communication

Ultraviolet radiation induces Melan-A-expressing cells in interfollicular epidermis in wild-type mice

verfasst von: David A. De Luca, Barbara Sterniczky, Susanne Kimeswenger, Dagmar Födinger, Agatha Schwarz, Thomas Schwarz, Christian Jantschitsch

Erschienen in: Archives of Dermatological Research | Ausgabe 6/2018

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Abstract

Adult wild-type mice are not supposed to be proper models for ultraviolet radiation (UVR)-induced melanoma since melanocytes are confined to hair follicles and cannot be sufficiently reached by UVR. On the other hand, in mutated mouse models used for melanoma research limitations, including an altered immune system and selection of affected pathways, lead to tumors phenotypically quite different from naturally occurring melanomas. We compared the distribution of epidermal melanocytes in UVR and not-UVR-exposed wild-type C57BL/6 mice. Starting at the age of 8 weeks, mice were exposed to physiologic doses of UVR three times weekly over 16 weeks. Back skin biopsies were taken 4, 8, 12 and 16 weeks after initiation of exposure, and stained for Melan-A, representing a highly selective marker for melanocytes. Surprisingly, after exposure to UVR, Melan-A positive cells were detected also in the interfollicular epidermis of C57BL/6 mice. We conclude that UVR is capable of inducing interfollicular epidermal melanocytes in wild-type mice.
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Metadaten
Titel
Ultraviolet radiation induces Melan-A-expressing cells in interfollicular epidermis in wild-type mice
verfasst von
David A. De Luca
Barbara Sterniczky
Susanne Kimeswenger
Dagmar Födinger
Agatha Schwarz
Thomas Schwarz
Christian Jantschitsch
Publikationsdatum
17.05.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Dermatological Research / Ausgabe 6/2018
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-018-1840-x

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