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Erschienen in: Annals of Surgical Oncology 10/2018

11.07.2018 | Breast Oncology

Underdiagnosis of Hereditary Breast and Ovarian Cancer in Medicare Patients: Genetic Testing Criteria Miss the Mark

verfasst von: Shan Yang, PhD, Jennifer E. Axilbund, MS, Erin O’Leary, MS, Scott T. Michalski, MS, Robbie Evans, BA, Stephen E. Lincoln, BS, Edward D. Esplin, MD, PhD, Robert L. Nussbaum, MD

Erschienen in: Annals of Surgical Oncology | Ausgabe 10/2018

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Abstract

Background

An estimated 5–10% of breast and ovarian cancers are due to hereditary causes such as hereditary breast and ovarian cancer (HBOC) syndrome. Medicare, the third-party payer that covers 44 million patients in the United States, has implemented a set of clinical criteria to determine coverage for the testing of the BRCA1 and BRCA2 genes. These criteria, developed to identify carriers of BRCA1/2 variants, have not been evaluated in the panel testing era. This study investigated a series of Medicare patients undergoing genetic testing for HBOC to determine the efficacy of genetic testing criteria in identifying patients with hereditary risk.

Methods

This study retrospectively examined de-identified data from a consecutive series of Medicare patients undergoing genetic testing based on personal and family history of breast and gynecologic cancer. Ordering clinicians indicated whether patients did or did not meet established criteria for BRCA1/2 genetic testing. The genetic test results were compared between the group that met the criteria and the group that did not. Patients in families with known pathogenic (P) or likely pathogenic (LP) variants were excluded from the primary analysis.

Results

Among 4196 unique Medicare patients, the rate of P/LP variants for the patients who met the criteria for genetic testing was 10.5%, and for those who did not, the rate was 9% (p = 0.26).

Conclusions

The results of this study indicate that a substantial number of Medicare patients with clinically actionable genetic variants are being missed by current testing criteria and suggest the need for significant expansion and simplification of the testing criteria for HBOC.
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Metadaten
Titel
Underdiagnosis of Hereditary Breast and Ovarian Cancer in Medicare Patients: Genetic Testing Criteria Miss the Mark
verfasst von
Shan Yang, PhD
Jennifer E. Axilbund, MS
Erin O’Leary, MS
Scott T. Michalski, MS
Robbie Evans, BA
Stephen E. Lincoln, BS
Edward D. Esplin, MD, PhD
Robert L. Nussbaum, MD
Publikationsdatum
11.07.2018
Verlag
Springer International Publishing
Erschienen in
Annals of Surgical Oncology / Ausgabe 10/2018
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-6621-4

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