Erschienen in:
01.08.2007 | Editorial
Understanding high-frequency oscillation: lessons from the animal kingdom
verfasst von:
Niall D. Ferguson, Jesús Villar, Arthur S. Slutsky
Erschienen in:
Intensive Care Medicine
|
Ausgabe 8/2007
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Excerpt
Our understanding of the mechanisms and importance of ventilator-induced lung injury (VILI) has advanced over the past three decades, in large part because of carefully conducted animal experiments [
1‐
4]. The principles derived and knowledge gained from these studies has subsequently been applied and tested in the clinical arena, leading to reductions in mortality in adults with the acute respiratory distress syndrome (ARDS) [
5,
6]. While significant progress has been made, mortality of ventilated patients with disease processes, such as ARDS, remains very high, and despite the advances, it is likely that this high mortality is still due partly to VILI. Many experimental and clinical questions related to VILI remain unanswered; one such area is the impact of high-frequency oscillation (HFO) on VILI in ARDS. …