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06.03.2018 | Commentary

Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers

verfasst von: Missak Haigentz Jr., Carlos Suarez, Primoz Strojan, Juan P. Rodrigo, Alessandra Rinaldo, Carol R. Bradford, June Corry, Robert P. Takes, Alfio Ferlito

Erschienen in: Advances in Therapy | Ausgabe 3/2018

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Abstract

The new 8th edition AJCC/UICC staging system for human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), developed to account for improved survival outcomes over HPV-negative cancers, includes anatomic features strictly associated with tumor-node-metastasis (TNM) and does not account for patient-specific characteristics that may impact prognosis. This commentary evaluates the evidence of smoking as an adverse prognostic factor in HPV-associated OPSCC. We review the multifactorial biological, clinical, and social/behavioral characteristics of smokers with OPSCC that impact outcomes, discuss current challenges with incorporating smoking history in prognostic classifications, and consider opportunities for future investigation.

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Titel: Understanding Interactions of Smoking on Prognosis of HPV-Associated Oropharyngeal Cancers
verfasst von: Missak Haigentz Jr.
Carlos Suarez
Primoz Strojan
Juan P. Rodrigo
Alessandra Rinaldo
Carol R. Bradford
June Corry
Robert P. Takes
Alfio Ferlito
Publikationsdatum: 06.03.2018
Verlag: Springer Healthcare
Erschienen in: Advances in Therapy / Ausgabe 3/2018
Print ISSN: 0741-238X
Elektronische ISSN: 1865-8652
DOI: https://doi.org/10.1007/s12325-018-0682-4

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