Lipids as a fuel source for energy supply during submaximal exercise originate from subcutaneous adipose tissue derived fatty acids (FA), intramuscular triacylglycerides (IMTG), cholesterol and dietary fat. These sources of fat contribute to fatty acid oxidation (FAox) in various ways. The regulation and utilization of FAs in a maximal capacity occur primarily at exercise intensities between 45 and 65% VO2max, is known as maximal fat oxidation (MFO), and is measured in g/min. Fatty acid oxidation occurs during submaximal exercise intensities, but is also complimentary to carbohydrate oxidation (CHOox). Due to limitations within FA transport across the cell and mitochondrial membranes, FAox is limited at higher exercise intensities. The point at which FAox reaches maximum and begins to decline is referred to as the crossover point. Exercise intensities that exceed the crossover point (~65% VO2max) utilize CHO as the predominant fuel source for energy supply. Training status, exercise intensity, exercise duration, sex differences, and nutrition have all been shown to affect cellular expression responsible for FAox rate. Each stimulus affects the process of FAox differently, resulting in specific adaptions that influence endurance exercise performance. Endurance training, specifically long duration (>2 h) facilitate adaptations that alter both the origin of FAs and FAox rate. Additionally, the influence of sex and nutrition on FAox are discussed. Finally, the role of FAox in the improvement of performance during endurance training is discussed.
Venables M, Achten J, Jeukendrup AE. Determinants of fat oxidation during exercise in healthy men and women: a cross-sectional study. J Appl Phys. 2005;98:160–7.
Brooks GA, Mercier J. Balance of carbohydrate and lipid utilization during exercise: the "crossover" concept. J Appl Phys. 1994;76(6):2253–61.
Valizadeh A, Khosravi A, Azmoon H. Fat oxidation rate during and after three exercise intensities in non-athlete young men. World Appl Sci J. 2011;15(9):1260–6.
Ogasawara J, Izawa T, Sakurai T, Sakurai T, Shirato K, Ishibashi Y, Ishida H, Ohno H, Kizaki T. The molecular mechanism underlying continuous exercise training-induced adaptive changes of lipolysis in white adipose cells. J Obesity. 2015; https://doi.org/10.1155/2015/473430.
Watt M, Spriet LL. Triacylglycerol lipases and metabolic control: implications for health and disease. Am J of Physol. Endocrinol Metab. 2010;299(2):162–8.
Tank A, Wong D. Peripheral and central effects of circulating catecholamines. Compr Physol. 2015;5:1–15.
van Hall G. THe physiological regulation of skeletal muscle fatty acid supply and oxidation during moderate-intensity exercise. Sports Med. 2015;Suppl 1:S23-S32.
Horowitz J, Klein S. Lipid metabolism during endurance exercise. Am J Clin Nutr. 2000;72(suppl):S558–63.
Frayn K. Fat as fuel: emerging understanding of the adipose tissue-skeletal muscle axis. Acta Physiol. 2010;199:509–18. CrossRef
Kiens B. Skeletal muscle lipid metabolism in exercise and insulin resistance. Physol Rev. 2006;86(1):205–43.
Jeppesen J, Keins B. Regulation and limitations to fatty acid oxidation during exercise. J Phys. 2012;1(590pt. 5):1059–68.
Klien S, Coyle E, Wolfe R. Fat metabolism during low-intensity exercise in endurance-trained and untrained men. Am J Phys. 1994;267(30):934–40.
Lundsgaard A, Kiens B. Gender differences in skeletal muscle substrate metabolism-molecular mechanisms and insulin sensitivity. Front Endocrinol. 2014;5(195):1–16.
DeLany J, Windhauser M, Champagne C, Bray G. Differential oxidation of individual dietary fatty acids in humans. Am J Clin Nutr. 2000;72:905–11. PubMed
Misell L, Lagomarcino N, Shuster V, Kern M. Chronic medium-chain triacylglycerol consumption and endurance performance in trained runners. J Sports Med Phys Fit. 2001;41:210–5.
Jeukendrup A, Aldred S. Fat supplementation, health, and endurance performance. Nutr. 2004;20:678–88. CrossRef
Volek J, Freidenreich D, Saenz C, Kunces L, Creighton B, Bartley, Davitt P, Munoz C, Anderson J, Maresh C, Lee E, Schuenke M, Aerni G, Kramer W, Phinney S. Metabolic characteristics of keto-adapted ultra-endurance runners. Metab. 2016;65:100–10. CrossRef
Scharhag-Rosenberger FM, Meyer T, Walitzek S, Kindermann W. Effects of one year aerobic endurance training on resting metabolic rate and exercise fat oxidation in previously untrained men and women. Metabolic endurance training adaptations. Int J Sports Med. 2010;31:498–504.
Lanzi S, Codecasa F, Cornacchia M, Maestrini S, Slvadori A, Brunani A, Malatesta D. Fat oxidation, hormonal and plasma metabolite kinetics during a submaximal incremental test in lean and obese adults. PLoS One. 2014;9(2) https://doi.org/10.1371/journal.pone.0088707.
Mora-Rodriguez R, Hodgkinson BJ, Byerley LO, Coyle EF. Effects of -adrenergic receptor stimulation and blockade on substrate metabolism during submaximal exercise. Am J Physol. Endocrinol Metab. 2001;280:752–60.
Martin W. Effects of acute and chronic exercise on fat metabolism. Exerc Sport Sci Revs. 1996;24:203–31.
Romijn J, Coyle E, Sidossis L, Gastaldelli A, Horowitz J, Endert E, Wolfe R. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. Am J phys. Endocrinol Metab. 1993;28:380–91.
Bergomaster K, Howarth KR, Phillips SM, Rakobowchuk M, MacDonald MJ, McGee SL, Gibala MJ. Similar metabolic adaptations during exercise after low volume sprint interval and traditional endurance training in humans. J Phys. 2008;586(1):151–60. CrossRef
Astorino T. Is the ventilatory threshold coincident with maximal fat oxidation during submaximal exercise in women? J Sports Med Phys Fitness. 2000;40:209–16. PubMed
Turcotte L, Richeter E, Kiens B. Increased plasma FFA uptake and oxidation during prolonged exericse in trained vs. untrained humans. Am J Physiol Endocrinol Metab. 1992;25:791–9. CrossRef
Maher A, Akhtar M, Vockley J, Tarnopolosky M. Women have higher protein content of beta oxidation enzymes in skeletal muscle than men. PLoS One. 2010;5(8) https://doi.org/10.1371/journal.pone.0012025.
Tarnopolosky M. Sex differences in exercise metabolism and the role of 17-beta estradiol. Med Sci Sports Exerc. 2008;40(4):648–54. CrossRef
Varmlamov O, Bethea CL, Roberts CT. Sex-specific differences in lipid and glucose metabolism. Front Endocrinol. 2015;5(241):1–7.
Carter S, Rennie C, Tarnopolosky M. Substrate utilization during endurance exercise in men and women after endurance training. Am J Endocrinoly Metab. 2001;280(6):898–907. CrossRef
Phinney S. Ketogenic diets and physical performance. Nutr Metab. 2004;1:2. CrossRef
Miles-Chan J, Dulloo AG, Schutz Y. Fasting substrate oxidation at rest assessed by indirect calorimetry: is prior dietary macronutrient level and composition a confounder? Int J Obes. 2015;39:1114–7. CrossRef
Stellingwerff T, Spriet LL, Watt M, Kimber N, Hargreaves M, Hawley J, Burkey L. Decreased PDH activiation and glycogenolysis during exercise following fat adaptation with carbohydrate resortation. Am J Endocrinol Metab. 2006;290:E380–8.
Webster C, Noakes T, Chacko S, Swart J, Kohn T, Smith J. Gluconeogenesis during endurance exercise in cyclists habituated to a long-term low carbohydrate high fat diet. J Physiol. 2016. https://doi.org/10.1113/JP271934.
Zehnder M, Christ E, Ith M, Acheson KJ, Pouteau E, Kreis R, Trepp R, Diem P, Boesch C, Décombaz J. Intramyocellular lipid stores increase markedly in athletes after 1.5 days lipid supplementation and are utilized during exercise in proportion to their content. Eur J Appl Physiol. 2006;98:341–54. PubMedCrossRef
Leckey J, Burke J, Morton J, Hawley J. Altering fatty acid availability does not impair prolonged, continuous running to fatigue: evidence for carbohydrate dependence. J of Appl Physiol. 2016;120(3):107–13.
- Understanding the factors that effect maximal fat oxidation
- BioMed Central
Journal of the International Society of Sports Nutrition
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