Dyspepsia is a common problem in the community and clinical practice with symptom(s) considered arising from the gastroduodenal region. Dyspepsia burden and associated factors vary from country to country. The aim of this study was to determine the prevalence of uninvestigated dyspepsia (UD) using Rome III criteria, associated risk factors and self-reported dyspepsia symptoms’ correlation with H. pylori infection.
A cross-sectional study was conducted among randomly selected 318 out patients with gastrointestinal complaints during the period from September 1 to December 30, 2015. All patients completed a questionnaire for collecting data regarding sociodemographic, lifestyle and functional gastrointestinal disorders. Diagnosis of dyspepsia was made according to the Rome III criteria. H. pylori infection was assessed using stool antigen test. SPSS version 20.0 statistical software package was used for data analysis.
From a total of 318 patients, 48.4% had UD according to Rome III criteria; with 42.1% symptoms of epigastric pain/burning, 26.1% postprandial fullness and 22.6% early satiation. Epigastric pain/burning (AOR = 1.92, 95% CI 1.07–3.43), early satiation (AOR = 2.68, 95% CI 1.38–5.20) and belching (AOR = 4.7, 95% CI 1.54–14.40) were significantly correlated with H. pylori infection. H. pylori infection (AOR = 4.33, 95% CI 2.41–7.76) and aspirin/NSAIDs consumption (AOR = 5.29, 95% CI 2.82–9.93) were independent risk factors for UD. However, consumption of raw fruits/ vegetables at least once a week (AOR = 0.48, 95% CI 0.24–0.98) and taking two or more cups of tea a day (AOR = 0.339, 95% CI 0.17–0.70) were inversely associated with UD.
UD is highly prevalent among adults with gastrointestinal complaints. H. pylori infection is significantly associated with UD and correlates with its symptoms. Individuals with epigastric pain/burning, early satiation and belching should be primary focus of H. pylori infection diagnosis and treatment. The role of consumption of tea, raw fruits and vegetables on dyspepsia needs further large scale study.
Drossman DA, Corazziari E, Delvaux M, Spiller RC, Talley NJ, Thompson WG, et al. In: Drossman DA, Corazziari E, Delvaux M, Spiller RC, Talley NJ, Thompson WG, Whitehead WE, editors. The functional gastrointestinal disorders. 3rd edn. Virginia: Degnon associates, Inc., McLean; 2006. p. 963–90.
Tepeš B. Subgroups of dyspepsia. In: Duvnjak M, editor. Dyspepsia in clinical practice. Springer; 2011. p. 9–18.
Drossman DA1, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, Whitehead WE, Janssens J, Funch-Jensen P, Corazziari E,. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig DisSci.1993;38: 1569–80.
Hasan M. Dyspepsia in primary care practice in Bangladesh. Bangladesh Med J .2013; 42 (2):63–69. A review article.
Ghoshal UC, Singh R, Chang FY, Hou X, Wong BC, Kachintorn U. Epidemiology of uninvestigated and functional dyspepsia in Asia: facts and fiction. J Neurogastroenterol Motil. 2011;17(3):235–44. doi: https://doi.org/10.5056/jnm.2011.17.3.235.
Yazdanpanah K, Moghimi N, Yousefinejad V, Ghaderi E, Azizi A, Nazem SF. Dyspepsia prevalence in general population aged over 20 in the west part of Iran. J Pak Med Assoc. 2012;62(7):672–6. PubMed
Rejchrt S, Koupil I, Kopa ´cˇova´ M, Vor, ´s˘ek V, Seifert B, Pozler O. Prevalence and sociodemographic determinants of uninvestigated dyspepsia in the Czech Republic. Eur J Gastroenterol Hepatol 2008; 20: 898–905.
Solomon OA, Ajayi AO. Risk factors for un-investigated dyspepsia among primary care patients in northern Nigeria. African health Science. 2013;13(4):1007–11. CrossRef
Tesfahun T, Yohannes M, Kassu D, Daniel A. Seroprevalence of helicobacter pylori infection in and its relationship with ABO blood groups. Ethiop.J.Health Dev .2005; 19(1):55–59.
Moayyedi P, Forman D, Braunholtz D, Feltbower R, Crocombe W, Liptrott M, Axon A. The proportion of upper gastrointestinal symptoms in the community associated with helicobacter pylori, lifestyle factors, and nonsteroidal anti-inflammatory drugs. Leeds HELP study group. The Am J Gastroenterol. 2000;95(6):1448–55. CrossRefPubMed
Gizachew T, Abebe H, Kassu D, Samuel E, Abate B. Association of dyspepsia symptoms and Helicobacter pylori infections in private higher clinic, Addis Ababa, Ethiopia. Ethiop Med J . 2011; 49 (2). Abstract.
Wubejig A, Mulugeta K, Bayeh A. Prevalence and risk factors of H. Pylori from dyspeptic patients in Northwest Ethiopia: a hospital based cross-sectional study. Asian Pac J Cancer Prev. 2014;15(11):4459–63. CrossRef
Asrat D, Nilsson I, Mengistu Y, Ashenafi S, Ayenew K, Al-Soud WA, Wadström T, Kassa E. Prevalence of helicobacter pylori infection among adult dyspeptic patients in Ethiopia. Trop Med Parasitol. 2004;98(2):181–9. CrossRef
Rome Foundation, “Rome III: A self-reported integrated questionnaire to diagnose adults for one or more functional gastrointestinal disorders, including alarm symptoms/red flags,” https://theromefoundation.org/products/copyright-and-licensing/.
Ogunmodede JA, Bojuwoye MO, Olokoba AB, Bolarinwa OA, Kolo PM. Self-reported symptoms of uninvestigated dyspepsia among university staff in Ilorin, Nigeria. Res. J. of Health Sci. 2016;4(4):296–303. CrossRef
Li M, Lu B, Chu L, Zhou H, Chen M-Y. Prevalence and characteristic of dyspepsia among college students in Zhejiang province. World j gastronology. 2014;20(13):3649–54. CrossRef
Lee J-Y, Hsu Y-C, Chen M-J, Tseng P-H, Chang C-Y, Yang T-H, Chang W-H, J-Y W, Wang H-P, Luo J-C, Lin J-T, Shun C-T, Distinct WM-S. Aetiopathogenesis in subgroups of functional dyspepsia according to the Rome III criteria. Gut. 2015;64:1517–28. https://doi.org/10.1136/gutjnl-2014-308114.
Nwokediuko SC, Ijoma U, Obienu O. Functional Dyspepsia: Subtypes, Risk Factors, and Overlap with Irritable Bowel Syndrome in a Population of African Patients. Gastroenterology Research and Practice, Article ID. 2012:562393, 5 pages. doi: https://doi.org/10.1155/2012/562393.
Seyedmirzaei S M, Haghdoost AA, Afshari M; Dehghani A. Prevalence of Dyspepsia and its Associated Factors Among the Adult Population in Southeast of Iran in 2010. Iran Red Crescent Med J. 2014; 16(11): e14757. doi: https://doi.org/10.5812/ircmj.14757.
Shokrzadeh L, Baghaei K, Yamaoka Y, Shiota S, Mirsattari D, Porhoseingholi A, Zali MR. Prevalence of helicobacter pylori infection in dyspeptic patients in Iran. Gastroenterology Insights. 2012;4:e8. doi: https://doi.org/10.4081/gi.2012.e8.
Wildner-christensen M, Hansen J M & Schaffalitzky de muckadell O B. Risk factors for dyspepsia in a general population: non-steroidal anti-inflammatory drugs, cigarette smoking and unemployment are more important than helicobacter pylori infection. Scand J Gastroenterol 2006; 41: 149–154.
Suzuki H, Matsuzaki J, Hibi T. What Is the Difference between Helicobacter pylori Associated Dyspepsia and Functional Dyspepsia?. J Neurogastroenterol Motil. 2011; 17(2):124–30. Review article.
Mohammad MA, Altayar M, Toboli AB, Bakk A. Characteristics of helicobacter pylori infection in libyan healthy peoples in two teaching hospitals in benghazi. Medical Journal of Islamic World Academy of Sciences. 2011;19(1):27–32.
Khan MA, Ghazi HO. Helicobacter pylori infection in asymptomatic subjects in Makkah Saudi Arabia. JPMA. 2007;57(3):114–7.
Shah SS, Bhatia SJ, Mistry FP. Epidemiology of dyspepsia in the general population in Mumbai. Indian J Gastroenterol. 2001;20:103–6. PubMed
Haque M, Wyeth JW, Stace NH, Talley NJ. Prevalence, severity and associated features of gastro-oesophageal reflux and dyspepsia: a population-based study. N Z Med J. 2000;113:178–81. PubMed
- Uninvestigated dyspepsia and associated factors of patients with gastrointestinal disorders in Dessie Referral Hospital, Northeast Ethiopia
- BioMed Central
Neu im Fachgebiet Innere Medizin
Meistgelesene Bücher aus der Inneren Medizin
Mail Icon II