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Erschienen in: Clinical Reviews in Allergy & Immunology 2/2018

11.09.2017

Unmet Needs in the Pathogenesis and Treatment of Vasculitides

verfasst von: Francesco Muratore, Giulia Pazzola, Alessandra Soriano, Nicolò Pipitone, Stefania Croci, Martina Bonacini, Luigi Boiardi, Carlo Salvarani

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 2/2018

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Abstract

Despite the progress in the last years on the field of vasculitides, there are several unmet needs regarding classification, disease activity assessment, predictors of flares and complications, and type of treatment for the different forms. The 1990 American College of Rheumatology (ACR) classification criteria currently used to define giant cell arteritis and Takayasu arteritis were designed to discriminate between different types of vasculitides but not to differentiate vasculitis from other disorders. Recently, efforts have been made to overcome the shortcomings of the ACR criteria. The lack of an accepted definition of disease activity in large-vessel vasculitides presents a major challenge in creating useful and valid outcome tools for the assessment of disease course. Identification of predictors of flares can aid in optimizing therapeutic strategies, minimizing disease flares, and reducing treatment-related side effects. It is furthermore important to recognize and characterize the risk factor that might predict the manifestations associated with poor outcome and prognosis. Two RCTs have evidenced the efficacy of tocilizumab in addition to glucocorticoids (GCs) in the treatment of giant cell arteritis (GCA). However, the role of tocilizumab or other biological agents without GCs needs to be investigated. Recent observational studies have suggested that rituximab is also effective in patients with eosinophilic granulomatosis with polyangiitis and in antineutrophil cytoplasmic antibodies (ANCA)-negative patients with granulomatosis with polyangiitis and microscopic polyangiitis. Rituximab or anti-TNF alfa may represent a possible alternative therapy in case of refractory or difficult to treat polyarteritis nodosa (PAN) patients. The new International Criteria for Behçet’s Disease have shown a better sensitivity and a better accuracy compared to the older International Study Group on Behçet’s Disease criteria. The EULAR recommendations for the management of Behçet’s disease (BD) have been recently updated. However, the treatment of refractory disease is still a real challenge.
Literatur
1.
Zurück zum Zitat Hunder GG, Bloch DA, Michel BA et al (1990) The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum 33:1122–1128PubMedCrossRef Hunder GG, Bloch DA, Michel BA et al (1990) The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis. Arthritis Rheum 33:1122–1128PubMedCrossRef
2.
Zurück zum Zitat Arend WP, Michel BA, Bloch DA et al (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 33:1129–1134PubMedCrossRef Arend WP, Michel BA, Bloch DA et al (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 33:1129–1134PubMedCrossRef
3.
Zurück zum Zitat Bongartz T, Matteson EL (2006) Large-vessel involvement in giant cell arteritis. Curr Opin Rheumatol 18:10–17PubMedCrossRef Bongartz T, Matteson EL (2006) Large-vessel involvement in giant cell arteritis. Curr Opin Rheumatol 18:10–17PubMedCrossRef
4.
Zurück zum Zitat Muratore F, Kermani TA, Crowson CS, Green AB, Salvarani C, Matteson EL, Warrington KJ (2015) Large-vessel giant cell arteritis: a cohort study. Rheumatology (Oxford) 54:463–470CrossRef Muratore F, Kermani TA, Crowson CS, Green AB, Salvarani C, Matteson EL, Warrington KJ (2015) Large-vessel giant cell arteritis: a cohort study. Rheumatology (Oxford) 54:463–470CrossRef
5.
Zurück zum Zitat Pipitone N, Versari A, Salvarani C (2008) Role of imaging studies in the diagnosis and follow-up of large-vessel vasculitis: an update. Rheumatology (Oxford) 47:403–408CrossRef Pipitone N, Versari A, Salvarani C (2008) Role of imaging studies in the diagnosis and follow-up of large-vessel vasculitis: an update. Rheumatology (Oxford) 47:403–408CrossRef
6.
Zurück zum Zitat Direskeneli H, Aydin SZ, Kermani TA et al (2011) Development of outcome measures for large-vessel vasculitis for use in clinical trials: opportunities, challenges, and research agenda. J Rheumatol 38:1471–1479PubMedPubMedCentralCrossRef Direskeneli H, Aydin SZ, Kermani TA et al (2011) Development of outcome measures for large-vessel vasculitis for use in clinical trials: opportunities, challenges, and research agenda. J Rheumatol 38:1471–1479PubMedPubMedCentralCrossRef
7.
Zurück zum Zitat Karahaliou M, Vaiopoulos G, Papaspyrou S, Kanakis MA, Revenas K, Sfikakis PP (2006) Colour duplex sonography of temporal arteries before decision for biopsy: a prospective study in 55 patients with suspected giant cell arteritis. Arthritis Res Ther 8(4):R116PubMedPubMedCentralCrossRef Karahaliou M, Vaiopoulos G, Papaspyrou S, Kanakis MA, Revenas K, Sfikakis PP (2006) Colour duplex sonography of temporal arteries before decision for biopsy: a prospective study in 55 patients with suspected giant cell arteritis. Arthritis Res Ther 8(4):R116PubMedPubMedCentralCrossRef
8.
Zurück zum Zitat Craven A, Robson J, Ponte C et al (2013) ACR/EULAR-endorsed study to develop Diagnostic and Classification Criteria for Vasculitis (DCVAS). Clin Exp Nephrol 17:619–621PubMedCrossRef Craven A, Robson J, Ponte C et al (2013) ACR/EULAR-endorsed study to develop Diagnostic and Classification Criteria for Vasculitis (DCVAS). Clin Exp Nephrol 17:619–621PubMedCrossRef
9.
Zurück zum Zitat Aydin SZ, Direskeneli H, Sreih A et al (2015) Update on outcome measure development for large vessel vasculitis: report from OMERACT 12. J Rheumatol 42:2465–2469PubMedPubMedCentralCrossRef Aydin SZ, Direskeneli H, Sreih A et al (2015) Update on outcome measure development for large vessel vasculitis: report from OMERACT 12. J Rheumatol 42:2465–2469PubMedPubMedCentralCrossRef
10.
Zurück zum Zitat Aydin SZ, Merkel PA, Direskeneli H (2015) Outcome measures for Takayasu's arteritis. Curr Opin Rheumatol 27:32–37PubMedCrossRef Aydin SZ, Merkel PA, Direskeneli H (2015) Outcome measures for Takayasu's arteritis. Curr Opin Rheumatol 27:32–37PubMedCrossRef
11.
Zurück zum Zitat Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M, Hoffman GS (1994) Takayasu arteritis. Ann Intern Med 120:919–929PubMedCrossRef Kerr GS, Hallahan CW, Giordano J, Leavitt RY, Fauci AS, Rottem M, Hoffman GS (1994) Takayasu arteritis. Ann Intern Med 120:919–929PubMedCrossRef
12.
Zurück zum Zitat Pipitone N, Pazzola G, Muratore F, Salvarani C (2013) L30. Assessment of vasculitis extent and severity. Presse Med 42(4 Pt 2):588–589PubMedCrossRef Pipitone N, Pazzola G, Muratore F, Salvarani C (2013) L30. Assessment of vasculitis extent and severity. Presse Med 42(4 Pt 2):588–589PubMedCrossRef
13.
Zurück zum Zitat Luqmani RA, Bacon PA, Moots RJ, Janssen BA, Pall A, Emery P, Savage C, Adu D (1994) Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis. QJM 87:671–678PubMed Luqmani RA, Bacon PA, Moots RJ, Janssen BA, Pall A, Emery P, Savage C, Adu D (1994) Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis. QJM 87:671–678PubMed
14.
Zurück zum Zitat Aydin SZ, Yilmaz N, Akar S et al (2010) Assessment of disease activity and progression in Takayasu's arteritis with Disease Extent Index-Takayasu. Rheumatology (Oxford) 49:1889–1893PubMedCrossRef Aydin SZ, Yilmaz N, Akar S et al (2010) Assessment of disease activity and progression in Takayasu's arteritis with Disease Extent Index-Takayasu. Rheumatology (Oxford) 49:1889–1893PubMedCrossRef
15.
Zurück zum Zitat Misra R, Danda D, Rajappa SM et al (2013) Development and initial validation of the Indian Takayasu Clinical Activity Score (ITAS2010). Rheumatology (Oxford) 52:1795–1801PubMedCrossRef Misra R, Danda D, Rajappa SM et al (2013) Development and initial validation of the Indian Takayasu Clinical Activity Score (ITAS2010). Rheumatology (Oxford) 52:1795–1801PubMedCrossRef
16.
Zurück zum Zitat Alibaz-Oner F, Aydin SZ, Akar S et al (2015) Assessment of patients with Takayasu arteritis in routine practice with Indian Takayasu clinical activity score. J Rheumatol 42:1443–1447PubMedCrossRef Alibaz-Oner F, Aydin SZ, Akar S et al (2015) Assessment of patients with Takayasu arteritis in routine practice with Indian Takayasu clinical activity score. J Rheumatol 42:1443–1447PubMedCrossRef
17.
Zurück zum Zitat Mason JC (2010) Takayasu arteritis—advances in diagnosis and management. Nat Rev Rheumatol 6:406–415PubMedCrossRef Mason JC (2010) Takayasu arteritis—advances in diagnosis and management. Nat Rev Rheumatol 6:406–415PubMedCrossRef
18.
Zurück zum Zitat Salvarani C, Cantini F, Hunder GG (2008) Polymyalgia rheumatica and giant-cell arteritis. Lancet 372:234–245PubMedCrossRef Salvarani C, Cantini F, Hunder GG (2008) Polymyalgia rheumatica and giant-cell arteritis. Lancet 372:234–245PubMedCrossRef
19.
Zurück zum Zitat Muratore F, Pipitone N, Salvarani C, Schmidt WA (2016) Imaging of vasculitis: state of the art. Best Pract Res Clin Rheumatol 30:688–706PubMedCrossRef Muratore F, Pipitone N, Salvarani C, Schmidt WA (2016) Imaging of vasculitis: state of the art. Best Pract Res Clin Rheumatol 30:688–706PubMedCrossRef
20.
Zurück zum Zitat Muratore F, Pipitone N, Salvarani C (2017) Standard and biological treatment in large vessel vasculitis: guidelines and current approaches. Expert Rev Clin Immunol 13:345–360PubMedCrossRef Muratore F, Pipitone N, Salvarani C (2017) Standard and biological treatment in large vessel vasculitis: guidelines and current approaches. Expert Rev Clin Immunol 13:345–360PubMedCrossRef
21.
Zurück zum Zitat Martinez-Lado L, Calvino-Diaz C, Pineiro A et al (2011) Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern Spain. Medicine (Baltimore) 90:186–193CrossRef Martinez-Lado L, Calvino-Diaz C, Pineiro A et al (2011) Relapses and recurrences in giant cell arteritis: a population-based study of patients with biopsy-proven disease from northwestern Spain. Medicine (Baltimore) 90:186–193CrossRef
22.
Zurück zum Zitat Alba MA, Garcia-Martinez A, Prieto-Gonzalez S et al (2014) Relapses in patients with giant cell arteritis: prevalence, characteristics, and associated clinical findings in a longitudinally followed cohort of 106 patients. Medicine (Baltimore) 93:194–201CrossRef Alba MA, Garcia-Martinez A, Prieto-Gonzalez S et al (2014) Relapses in patients with giant cell arteritis: prevalence, characteristics, and associated clinical findings in a longitudinally followed cohort of 106 patients. Medicine (Baltimore) 93:194–201CrossRef
23.
Zurück zum Zitat Liozon E, Roblot P, Paire D et al (2000) Anticardiolipin antibody levels predict flares and relapses in patients with giant-cell (temporal) arteritis. A longitudinal study of 58 biopsy-proven cases. Rheumatology 39:1089–1094PubMedCrossRef Liozon E, Roblot P, Paire D et al (2000) Anticardiolipin antibody levels predict flares and relapses in patients with giant-cell (temporal) arteritis. A longitudinal study of 58 biopsy-proven cases. Rheumatology 39:1089–1094PubMedCrossRef
24.
Zurück zum Zitat Proven A, Gabriel SE, Orces C, O'Fallon WM, Hunder GG (2003) Glucocorticoid therapy in giant cell arteritis: duration and adverse outcomes. Arthritis Rheum 49:703–708PubMedCrossRef Proven A, Gabriel SE, Orces C, O'Fallon WM, Hunder GG (2003) Glucocorticoid therapy in giant cell arteritis: duration and adverse outcomes. Arthritis Rheum 49:703–708PubMedCrossRef
25.
Zurück zum Zitat Labarca C, Koster MJ, Crowson CS, Makol A, Ytterberg SR, Matteson EL, Warrington KJ (2016) Predictors of relapse and treatment outcomes in biopsy-proven giant cell arteritis: a retrospective cohort study. Rheumatology (Oxford) 55:347–356CrossRef Labarca C, Koster MJ, Crowson CS, Makol A, Ytterberg SR, Matteson EL, Warrington KJ (2016) Predictors of relapse and treatment outcomes in biopsy-proven giant cell arteritis: a retrospective cohort study. Rheumatology (Oxford) 55:347–356CrossRef
26.
Zurück zum Zitat Kermani TA, Warrington KJ, Cuthbertson D et al (2015) Disease relapses among patients with giant cell arteritis: a prospective longitudinal cohort study. J Rheumatol 42:1213–1217PubMedPubMedCentralCrossRef Kermani TA, Warrington KJ, Cuthbertson D et al (2015) Disease relapses among patients with giant cell arteritis: a prospective longitudinal cohort study. J Rheumatol 42:1213–1217PubMedPubMedCentralCrossRef
27.
Zurück zum Zitat Restuccia G, Boiardi L, Cavazza A et al (2016) Flares in biopsy-proven giant cell arteritis in northern Italy: characteristics and predictors in a long-term follow-up study. Medicine (Baltimore) 95:e3524CrossRef Restuccia G, Boiardi L, Cavazza A et al (2016) Flares in biopsy-proven giant cell arteritis in northern Italy: characteristics and predictors in a long-term follow-up study. Medicine (Baltimore) 95:e3524CrossRef
29.
Zurück zum Zitat Schmidt J, Kermani TA, Bacani AK, Crowson CS, Cooper LT, Matteson EL, Warrington KJ (2013) Diagnostic features, treatment, and outcomes of Takayasu arteritis in a US cohort of 126 patients. Mayo Clin Proc 88:822–830PubMedCrossRef Schmidt J, Kermani TA, Bacani AK, Crowson CS, Cooper LT, Matteson EL, Warrington KJ (2013) Diagnostic features, treatment, and outcomes of Takayasu arteritis in a US cohort of 126 patients. Mayo Clin Proc 88:822–830PubMedCrossRef
30.
Zurück zum Zitat Hong S, Bae SH, Ahn SM, Lim DH, Kim YG, Lee CK, Yoo B (2015) Outcome of Takayasu arteritis with inactive disease at diagnosis: the extent of vascular involvement as a predictor of activation. J Rheumatol 42:489–494PubMedCrossRef Hong S, Bae SH, Ahn SM, Lim DH, Kim YG, Lee CK, Yoo B (2015) Outcome of Takayasu arteritis with inactive disease at diagnosis: the extent of vascular involvement as a predictor of activation. J Rheumatol 42:489–494PubMedCrossRef
31.
Zurück zum Zitat Ohigashi H, Haraguchi G, Konishi M, Tezuka D, Kamiishi T, Ishihara T, Isobe M (2012) Improved prognosis of Takayasu arteritis over the past decade—comprehensive analysis of 106 patients. Circ J 76:1004–1011PubMedCrossRef Ohigashi H, Haraguchi G, Konishi M, Tezuka D, Kamiishi T, Ishihara T, Isobe M (2012) Improved prognosis of Takayasu arteritis over the past decade—comprehensive analysis of 106 patients. Circ J 76:1004–1011PubMedCrossRef
32.
Zurück zum Zitat Fukui S, Iwamoto N, Shimizu T et al (2016) Fewer subsequent relapses and lower levels of IL-17 in Takayasu arteritis developed after the age of 40 years. Arthritis Res Ther 18:293PubMedPubMedCentralCrossRef Fukui S, Iwamoto N, Shimizu T et al (2016) Fewer subsequent relapses and lower levels of IL-17 in Takayasu arteritis developed after the age of 40 years. Arthritis Res Ther 18:293PubMedPubMedCentralCrossRef
33.
Zurück zum Zitat Westman K, Flossmann O, Gregorini G (2015) The long-term outcomes of systemic vasculitis. Nephrol Dial Transplant 30(Suppl 1):i60–i66PubMed Westman K, Flossmann O, Gregorini G (2015) The long-term outcomes of systemic vasculitis. Nephrol Dial Transplant 30(Suppl 1):i60–i66PubMed
34.
Zurück zum Zitat Walsh M, Flossmann O, Berden A et al (2012) Risk factors for relapse of antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 64:542–548PubMedCrossRef Walsh M, Flossmann O, Berden A et al (2012) Risk factors for relapse of antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 64:542–548PubMedCrossRef
35.
Zurück zum Zitat Booth AD, Almond MK, Burns A et al (2003) Outcome of ANCA-associated renal vasculitis: a 5-year retrospective study. Am J Kidney Dis 41:776–784PubMedCrossRef Booth AD, Almond MK, Burns A et al (2003) Outcome of ANCA-associated renal vasculitis: a 5-year retrospective study. Am J Kidney Dis 41:776–784PubMedCrossRef
36.
Zurück zum Zitat Westman KW, Bygren PG, Olsson H et al (1998) Relapse rate, renal survival, and cancer morbidity in patients with Wegener’s granulomatosis or microscopic polyangiitis with renal involvement. J Am Soc Nephrol 9:842–852PubMed Westman KW, Bygren PG, Olsson H et al (1998) Relapse rate, renal survival, and cancer morbidity in patients with Wegener’s granulomatosis or microscopic polyangiitis with renal involvement. J Am Soc Nephrol 9:842–852PubMed
37.
Zurück zum Zitat Pagnoux C, Hogan SL, Chin H et al (2008) Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: comparison of two independent cohorts. Arthritis Rheum 58:2908–2918PubMedPubMedCentralCrossRef Pagnoux C, Hogan SL, Chin H et al (2008) Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody-associated small-vessel vasculitis: comparison of two independent cohorts. Arthritis Rheum 58:2908–2918PubMedPubMedCentralCrossRef
38.
Zurück zum Zitat Kemna MJ, Damoiseaux J, Austen J, Winkens B, Peters J, van Paassen P, Cohen Tervaert JW (2015) ANCA as a predictor of relapse: useful in patients with renal involvement but not in patients with nonrenal disease. J Am Soc Nephrol 26:537–542PubMedCrossRef Kemna MJ, Damoiseaux J, Austen J, Winkens B, Peters J, van Paassen P, Cohen Tervaert JW (2015) ANCA as a predictor of relapse: useful in patients with renal involvement but not in patients with nonrenal disease. J Am Soc Nephrol 26:537–542PubMedCrossRef
39.
Zurück zum Zitat Fussner LA, Hummel AM, Schroeder DR et al (2016) Factors determining the clinical utility of serial measurements of antineutrophil cytoplasmic antibodies targeting proteinase 3. Arthritis Rheum 68:1700–1710CrossRef Fussner LA, Hummel AM, Schroeder DR et al (2016) Factors determining the clinical utility of serial measurements of antineutrophil cytoplasmic antibodies targeting proteinase 3. Arthritis Rheum 68:1700–1710CrossRef
40.
Zurück zum Zitat Morgan MD, Szeto M, Walsh M et al (2017) Negative anti-neutrophil cytoplasm antibody at switch to maintenance therapy is associated with a reduced risk of relapse. Arthritis Res Ther 19:129PubMedPubMedCentralCrossRef Morgan MD, Szeto M, Walsh M et al (2017) Negative anti-neutrophil cytoplasm antibody at switch to maintenance therapy is associated with a reduced risk of relapse. Arthritis Res Ther 19:129PubMedPubMedCentralCrossRef
41.
Zurück zum Zitat Harper L, Morgan MD, Walsh M et al (2012) Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up. Ann Rheum Dis 71:955–960PubMedCrossRef Harper L, Morgan MD, Walsh M et al (2012) Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis: long-term follow-up. Ann Rheum Dis 71:955–960PubMedCrossRef
42.
Zurück zum Zitat Faurschou M, Westman K, Rasmussen N et al (2012) Long-term outcome of a clinical trial comparing methotrexate to cyclophosphamide for remission induction of early systemic ANCA-associated vasculitis. Arthritis Rheum 64:3472–3477PubMedCrossRef Faurschou M, Westman K, Rasmussen N et al (2012) Long-term outcome of a clinical trial comparing methotrexate to cyclophosphamide for remission induction of early systemic ANCA-associated vasculitis. Arthritis Rheum 64:3472–3477PubMedCrossRef
44.
Zurück zum Zitat Guillevin L, Pagnoux C, Karras A et al (2014) Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis. N Engl J Med 371:1771–1780PubMedCrossRef Guillevin L, Pagnoux C, Karras A et al (2014) Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis. N Engl J Med 371:1771–1780PubMedCrossRef
45.
Zurück zum Zitat Walsh M, Merkel PA, Mahr A et al (2010) Effects of duration of glucocorticoid therapy on relapse rate in antineutrophil cytoplasmic antibody-associated vasculitis: a meta-analysis. Arthritis Care Res 62:1166–1173CrossRef Walsh M, Merkel PA, Mahr A et al (2010) Effects of duration of glucocorticoid therapy on relapse rate in antineutrophil cytoplasmic antibody-associated vasculitis: a meta-analysis. Arthritis Care Res 62:1166–1173CrossRef
46.
Zurück zum Zitat Soriano A, Muratore F, Pipitone N, Boiardi L, Cimino L, Salvarani C (2017) Visual loss and other cranial ischaemic complications in giant cell arteritis. Nat Rev Rheumatol 13:476–484PubMedCrossRef Soriano A, Muratore F, Pipitone N, Boiardi L, Cimino L, Salvarani C (2017) Visual loss and other cranial ischaemic complications in giant cell arteritis. Nat Rev Rheumatol 13:476–484PubMedCrossRef
47.
Zurück zum Zitat Evans JM, O'Fallon WM, Hunder GG (1995) Increased incidence of aortic aneurysm and dissection in giant cell (temporal) arteritis. A population-based study. Ann Intern Med 122:502–507PubMedCrossRef Evans JM, O'Fallon WM, Hunder GG (1995) Increased incidence of aortic aneurysm and dissection in giant cell (temporal) arteritis. A population-based study. Ann Intern Med 122:502–507PubMedCrossRef
48.
Zurück zum Zitat Robson JC, Kiran A, Maskell J et al (2015) The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK. Ann Rheum Dis 74:129–135PubMedCrossRef Robson JC, Kiran A, Maskell J et al (2015) The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK. Ann Rheum Dis 74:129–135PubMedCrossRef
49.
Zurück zum Zitat Kermani TA, Warrington KJ, Crowson CS, Ytterberg SR, Hunder GG, Gabriel SE, Matteson EL (2013) Large-vessel involvement in giant cell arteritis: a population-based cohort study of the incidence—trends and prognosis. Ann Rheum Dis 72:1989–1994PubMedCrossRef Kermani TA, Warrington KJ, Crowson CS, Ytterberg SR, Hunder GG, Gabriel SE, Matteson EL (2013) Large-vessel involvement in giant cell arteritis: a population-based cohort study of the incidence—trends and prognosis. Ann Rheum Dis 72:1989–1994PubMedCrossRef
50.
Zurück zum Zitat Mackie SL, Hensor EM, Morgan AW, Pease CT (2014) Should I send my patient with previous giant cell arteritis for imaging of the thoracic aorta? A systematic literature review and meta-analysis. Ann Rheum Dis 73:143–148PubMedCrossRef Mackie SL, Hensor EM, Morgan AW, Pease CT (2014) Should I send my patient with previous giant cell arteritis for imaging of the thoracic aorta? A systematic literature review and meta-analysis. Ann Rheum Dis 73:143–148PubMedCrossRef
51.
Zurück zum Zitat Hill CL, Black RJ, Nossent JC, Ruediger C, Nguyen L, Ninan JV, Lester S (2017) Risk of mortality in patients with giant cell arteritis: a systematic review and meta-analysis. Semin Arthritis Rheum 46:513–519PubMedCrossRef Hill CL, Black RJ, Nossent JC, Ruediger C, Nguyen L, Ninan JV, Lester S (2017) Risk of mortality in patients with giant cell arteritis: a systematic review and meta-analysis. Semin Arthritis Rheum 46:513–519PubMedCrossRef
52.
Zurück zum Zitat Direskeneli H (2017) Clinical assessment in Takayasu's arteritis: major challenges and controversies. Clin Exp Rheumatol 35(Suppl 103):189–193PubMed Direskeneli H (2017) Clinical assessment in Takayasu's arteritis: major challenges and controversies. Clin Exp Rheumatol 35(Suppl 103):189–193PubMed
53.
Zurück zum Zitat Grayson PC, Cuthbertson D, Carette S et al (2013) New features of disease after diagnosis in 6 forms of systemic vasculitis. J Rheumatol 40:1905–1912PubMedPubMedCentralCrossRef Grayson PC, Cuthbertson D, Carette S et al (2013) New features of disease after diagnosis in 6 forms of systemic vasculitis. J Rheumatol 40:1905–1912PubMedPubMedCentralCrossRef
54.
Zurück zum Zitat Omma A, Erer B, Karadag O et al (2017) Remarkable damage along with poor quality of life in Takayasu arteritis: cross-sectional results of a long-term followed-up multicentre cohort. Clin Exp Rheumatol 35(Suppl 103):77–82PubMed Omma A, Erer B, Karadag O et al (2017) Remarkable damage along with poor quality of life in Takayasu arteritis: cross-sectional results of a long-term followed-up multicentre cohort. Clin Exp Rheumatol 35(Suppl 103):77–82PubMed
55.
Zurück zum Zitat Machen L, Clowse ME (2017) Vasculitis and pregnancy. Rheum Dis Clin N Am 43:239–247CrossRef Machen L, Clowse ME (2017) Vasculitis and pregnancy. Rheum Dis Clin N Am 43:239–247CrossRef
56.
Zurück zum Zitat Gatto M, Iaccarino L, Canova M, Zen M, Nalotto L, Ramonda R, Punzi L, Doria A (2012) Pregnancy and vasculitis: a systematic review of the literature. Autoimmun Rev 11:A447–A459PubMedCrossRef Gatto M, Iaccarino L, Canova M, Zen M, Nalotto L, Ramonda R, Punzi L, Doria A (2012) Pregnancy and vasculitis: a systematic review of the literature. Autoimmun Rev 11:A447–A459PubMedCrossRef
58.
Zurück zum Zitat Ishikawa K, Maetani S (1994) Long-term outcome for 120 Japanese patients with Takayasu's disease. Clinical and statistical analyses of related prognostic factors. Circulation 90:1855–1860PubMedCrossRef Ishikawa K, Maetani S (1994) Long-term outcome for 120 Japanese patients with Takayasu's disease. Clinical and statistical analyses of related prognostic factors. Circulation 90:1855–1860PubMedCrossRef
59.
Zurück zum Zitat Park MC, Lee SW, Park YB, Chung NS, Lee SK (2005) Clinical characteristics and outcomes of Takayasu's arteritis: analysis of 108 patients using standardised criteria for diagnosis, activity assessment, and angiographic classification. Scand J Rheumatol 34:284–292PubMedCrossRef Park MC, Lee SW, Park YB, Chung NS, Lee SK (2005) Clinical characteristics and outcomes of Takayasu's arteritis: analysis of 108 patients using standardised criteria for diagnosis, activity assessment, and angiographic classification. Scand J Rheumatol 34:284–292PubMedCrossRef
60.
Zurück zum Zitat Li J, Zhu M, Li M, Zheng W, Zhao J, Tian X, Zeng X (2016) Cause of death in Chinese Takayasu arteritis patients. Medicine (Baltimore) 95:e4069CrossRef Li J, Zhu M, Li M, Zheng W, Zhao J, Tian X, Zeng X (2016) Cause of death in Chinese Takayasu arteritis patients. Medicine (Baltimore) 95:e4069CrossRef
61.
Zurück zum Zitat Flossmann O, Berden A, de Groot K et al (2011) Long-term patient survival in ANCA-associated vasculitis. Ann Rheum Dis 70:488–494PubMedCrossRef Flossmann O, Berden A, de Groot K et al (2011) Long-term patient survival in ANCA-associated vasculitis. Ann Rheum Dis 70:488–494PubMedCrossRef
62.
Zurück zum Zitat Guillevin L, Lhote F, Gayraud M, Cohen P, Jarrousse B, Lortholary O, Thibult N, Casassus P (1996) Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients. Medicine (Baltimore) 75:17–28CrossRef Guillevin L, Lhote F, Gayraud M, Cohen P, Jarrousse B, Lortholary O, Thibult N, Casassus P (1996) Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients. Medicine (Baltimore) 75:17–28CrossRef
63.
Zurück zum Zitat Guillevin L, Pagnoux C, Seror R et al (2011) The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort. Medicine (Baltimore) 90:19–27CrossRef Guillevin L, Pagnoux C, Seror R et al (2011) The Five-Factor Score revisited: assessment of prognoses of systemic necrotizing vasculitides based on the French Vasculitis Study Group (FVSG) cohort. Medicine (Baltimore) 90:19–27CrossRef
64.
Zurück zum Zitat Holle JU, Gross WL, Latza U et al (2011) Improved outcome in 445 patients with Wegener’s granulomatosis in a German vasculitis center over four decades. Arthritis Rheum 63:257–266PubMedCrossRef Holle JU, Gross WL, Latza U et al (2011) Improved outcome in 445 patients with Wegener’s granulomatosis in a German vasculitis center over four decades. Arthritis Rheum 63:257–266PubMedCrossRef
65.
Zurück zum Zitat Mohammad AJ, Segelmark M (2014) A population-based study showing better renal prognosis for proteinase 3 antineutrophil cytoplasmic antibody (ANCA)-associated nephritis versus myeloperoxidase ANCA-associated nephritis. J Rheumatol 41:1366–1373PubMedCrossRef Mohammad AJ, Segelmark M (2014) A population-based study showing better renal prognosis for proteinase 3 antineutrophil cytoplasmic antibody (ANCA)-associated nephritis versus myeloperoxidase ANCA-associated nephritis. J Rheumatol 41:1366–1373PubMedCrossRef
66.
Zurück zum Zitat Jayne DR, Gaskin G, Rasmussen N et al (2007) Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis. J Am Soc Nephrol 18:2180–2188PubMedCrossRef Jayne DR, Gaskin G, Rasmussen N et al (2007) Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis. J Am Soc Nephrol 18:2180–2188PubMedCrossRef
67.
Zurück zum Zitat de Joode AA, Sanders JS, Stegeman CA (2013) Renal survival in proteinase 3 and myeloperoxidase ANCA-associated systemic vasculitis. Clin J Am Soc Nephrol 8:1709–1717PubMedPubMedCentralCrossRef de Joode AA, Sanders JS, Stegeman CA (2013) Renal survival in proteinase 3 and myeloperoxidase ANCA-associated systemic vasculitis. Clin J Am Soc Nephrol 8:1709–1717PubMedPubMedCentralCrossRef
68.
Zurück zum Zitat Marco H, Mirapeix E, Arcos E et al (2013) Long-term outcome of antineutrophil cytoplasmic antibody-associated small vessel vasculitis after renal transplantation. Clin Transpl 27:338–347CrossRef Marco H, Mirapeix E, Arcos E et al (2013) Long-term outcome of antineutrophil cytoplasmic antibody-associated small vessel vasculitis after renal transplantation. Clin Transpl 27:338–347CrossRef
69.
Zurück zum Zitat Berden AE, Ferrario F, Hagen EC et al (2010) Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol 21:1628–1636PubMedCrossRef Berden AE, Ferrario F, Hagen EC et al (2010) Histopathologic classification of ANCA-associated glomerulonephritis. J Am Soc Nephrol 21:1628–1636PubMedCrossRef
70.
Zurück zum Zitat Goupil R, Brachemi S, Nadeau-Fredette AC, Déziel C, Troyanov Y, Lavergne V, Troyanov S (2013) Lymphopenia and treatment-related infectious complications in ANCA-associated vasculitis. Clin J Am Soc Nephrol 8:416–423PubMedCrossRef Goupil R, Brachemi S, Nadeau-Fredette AC, Déziel C, Troyanov Y, Lavergne V, Troyanov S (2013) Lymphopenia and treatment-related infectious complications in ANCA-associated vasculitis. Clin J Am Soc Nephrol 8:416–423PubMedCrossRef
71.
Zurück zum Zitat Hoffman GS, Kerr GS, Leavitt RY et al (1992) Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med 116:488–498PubMedCrossRef Hoffman GS, Kerr GS, Leavitt RY et al (1992) Wegener granulomatosis: an analysis of 158 patients. Ann Intern Med 116:488–498PubMedCrossRef
72.
Zurück zum Zitat Faurschou M, Sorensen IJ, Mellemkjaer L et al (2008) Malignancies in Wegener's granulomatosis: incidence and relation to cyclophosphamide therapy in a cohort of 293 patients. J Rheumatol 35:100–105PubMed Faurschou M, Sorensen IJ, Mellemkjaer L et al (2008) Malignancies in Wegener's granulomatosis: incidence and relation to cyclophosphamide therapy in a cohort of 293 patients. J Rheumatol 35:100–105PubMed
73.
Zurück zum Zitat Heijl C, Harper L, Flossmann O et al (2011) Incidence of malignancy in patients treated for antineutrophil cytoplasm antibody-associated vasculitis: follow-up data from European Vasculitis Study Group clinical trials. Ann Rheum Dis 70:1415–1421PubMedCrossRef Heijl C, Harper L, Flossmann O et al (2011) Incidence of malignancy in patients treated for antineutrophil cytoplasm antibody-associated vasculitis: follow-up data from European Vasculitis Study Group clinical trials. Ann Rheum Dis 70:1415–1421PubMedCrossRef
74.
Zurück zum Zitat Robson J, Doll H, Suppiah R et al (2015) Damage in the ANCA-associated vasculitides: long-term data from the European Vasculitis Study Group (EUVAS) therapeutic trials. Ann Rheum Dis 74:177–184PubMedCrossRef Robson J, Doll H, Suppiah R et al (2015) Damage in the ANCA-associated vasculitides: long-term data from the European Vasculitis Study Group (EUVAS) therapeutic trials. Ann Rheum Dis 74:177–184PubMedCrossRef
75.
Zurück zum Zitat Robson J, Doll H, Suppiah R et al (2014) Glucocorticoid treatment and damage in the anti-neutrophil cytoplasm antibody-associated vasculitides: long-term data from the European Vasculitis Study Group trials. Rheumatology (Oxford) 54:471–481CrossRef Robson J, Doll H, Suppiah R et al (2014) Glucocorticoid treatment and damage in the anti-neutrophil cytoplasm antibody-associated vasculitides: long-term data from the European Vasculitis Study Group trials. Rheumatology (Oxford) 54:471–481CrossRef
76.
Zurück zum Zitat Nesher G, Sonnenblick M, Friedlander Y (1994) Analysis of steroid related complications and mortality in temporal arteritis: a 15-year survey of 43 patients. J Rheumatol 21:1283–1286PubMed Nesher G, Sonnenblick M, Friedlander Y (1994) Analysis of steroid related complications and mortality in temporal arteritis: a 15-year survey of 43 patients. J Rheumatol 21:1283–1286PubMed
77.
Zurück zum Zitat Hoes JN, Jacobs JW, Boers M et al (2007) EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases. Ann Rheum Dis 66:1560–1567PubMedPubMedCentralCrossRef Hoes JN, Jacobs JW, Boers M et al (2007) EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases. Ann Rheum Dis 66:1560–1567PubMedPubMedCentralCrossRef
78.
Zurück zum Zitat Condon MB, Ashby D, Pepper RJ, Cook HT, Levy JB, Griffith M, Cairns TD, Lightstone L (2013) Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids. Ann Rheum Dis 72:1280–1286PubMedCrossRef Condon MB, Ashby D, Pepper RJ, Cook HT, Levy JB, Griffith M, Cairns TD, Lightstone L (2013) Prospective observational single-centre cohort study to evaluate the effectiveness of treating lupus nephritis with rituximab and mycophenolate mofetil but no oral steroids. Ann Rheum Dis 72:1280–1286PubMedCrossRef
79.
Zurück zum Zitat Wagner AD, Wittkop U, Prahst A, Schmidt WA, Gromnica-Ihle E, Vorpahl K, Hudson AP, Zeidler H (2003) Dendritic cells co-localize with activated CD4+ T cells in giant cell arteritis. Clin Exp Rheumatol 21:185–192PubMed Wagner AD, Wittkop U, Prahst A, Schmidt WA, Gromnica-Ihle E, Vorpahl K, Hudson AP, Zeidler H (2003) Dendritic cells co-localize with activated CD4+ T cells in giant cell arteritis. Clin Exp Rheumatol 21:185–192PubMed
80.
Zurück zum Zitat Andonopoulos AP, Meimaris N, Daoussis D, Bounas A, Giannopoulos G (2003) Experience with infliximab (anti-TNF alpha monoclonal antibody) as monotherapy for giant cell arteritis. Ann Rheum Dis 62:1116PubMedPubMedCentralCrossRef Andonopoulos AP, Meimaris N, Daoussis D, Bounas A, Giannopoulos G (2003) Experience with infliximab (anti-TNF alpha monoclonal antibody) as monotherapy for giant cell arteritis. Ann Rheum Dis 62:1116PubMedPubMedCentralCrossRef
81.
Zurück zum Zitat Uthman I, Kanj N, Atweh S (2006) Infliximab as monotherapy in giant cell arteritis. Clin Rheumatol 25:109–110PubMedCrossRef Uthman I, Kanj N, Atweh S (2006) Infliximab as monotherapy in giant cell arteritis. Clin Rheumatol 25:109–110PubMedCrossRef
82.
Zurück zum Zitat Hoffman GS, Cid MC, Rendt-Zagar KE et al (2007) Infliximab for maintenance of glucocorticosteroid-induced remission of giant cell arteritis: a randomized trial. Ann Intern Med 146:621–630PubMedCrossRef Hoffman GS, Cid MC, Rendt-Zagar KE et al (2007) Infliximab for maintenance of glucocorticosteroid-induced remission of giant cell arteritis: a randomized trial. Ann Intern Med 146:621–630PubMedCrossRef
83.
Zurück zum Zitat Roche NE, Fulbright JW, Wagner AD, Hunder GG, Goronzy JJ, Weyand CM (1993) Correlation of interleukin-6 production and disease activity in polymyalgia rheumatica and giant cell arteritis. Arthritis Rheum 36:1286–1294PubMedCrossRef Roche NE, Fulbright JW, Wagner AD, Hunder GG, Goronzy JJ, Weyand CM (1993) Correlation of interleukin-6 production and disease activity in polymyalgia rheumatica and giant cell arteritis. Arthritis Rheum 36:1286–1294PubMedCrossRef
84.
Zurück zum Zitat Noris M, Daina E, Gamba S, Bonazzola S, Remuzzi G (1999) Interleukin-6 and RANTES in Takayasu arteritis: a guide for therapeutic decisions? Circulation 100:55–60PubMedCrossRef Noris M, Daina E, Gamba S, Bonazzola S, Remuzzi G (1999) Interleukin-6 and RANTES in Takayasu arteritis: a guide for therapeutic decisions? Circulation 100:55–60PubMedCrossRef
85.
Zurück zum Zitat Stone JH, Tuckwell K, Dimonaco S et al (2017 Jul) Trial of tocilizumab in giant-cell arteritis. N Engl J Med 377:317–328PubMedCrossRef Stone JH, Tuckwell K, Dimonaco S et al (2017 Jul) Trial of tocilizumab in giant-cell arteritis. N Engl J Med 377:317–328PubMedCrossRef
86.
Zurück zum Zitat Pazzola G, Padovano I, Boiardi L et al (2013) Tocilizumab in glucocorticoid-naïve large-vessel vasculitis. Clin Exp Rheumatol 31(1 Suppl 75):S59–S61PubMed Pazzola G, Padovano I, Boiardi L et al (2013) Tocilizumab in glucocorticoid-naïve large-vessel vasculitis. Clin Exp Rheumatol 31(1 Suppl 75):S59–S61PubMed
87.
Zurück zum Zitat Salvarani C, Magnani L, Catanoso M et al (2012) Tocilizumab: a novel therapy for patients with large-vessel vasculitis. Rheumatology (Oxford) 51:151–156CrossRef Salvarani C, Magnani L, Catanoso M et al (2012) Tocilizumab: a novel therapy for patients with large-vessel vasculitis. Rheumatology (Oxford) 51:151–156CrossRef
88.
Zurück zum Zitat Seitz M, Reichenbach S, Bonel HM, Adler S, Wermelinger F, Villiger PM (2011) Rapid induction of remission in large vessel vasculitis by IL-6 blockade. A case series. Swiss Med Wkly 141:w13156PubMed Seitz M, Reichenbach S, Bonel HM, Adler S, Wermelinger F, Villiger PM (2011) Rapid induction of remission in large vessel vasculitis by IL-6 blockade. A case series. Swiss Med Wkly 141:w13156PubMed
89.
Zurück zum Zitat Hernández-Rodríguez J, Segarra M, Vilardell C et al (2003) Elevated production of interleukin-6 is associated with a lower incidence of disease-related ischemic events in patients with giant-cell arteritis: angiogenic activity of interleukin-6 as a potential protective mechanism. Circulation 107:2428–2434PubMedCrossRef Hernández-Rodríguez J, Segarra M, Vilardell C et al (2003) Elevated production of interleukin-6 is associated with a lower incidence of disease-related ischemic events in patients with giant-cell arteritis: angiogenic activity of interleukin-6 as a potential protective mechanism. Circulation 107:2428–2434PubMedCrossRef
91.
Zurück zum Zitat Jennette JC, Falk RJ (1995) Clinical and pathological classification of ANCA-associated vasculitis: what are the controversies? Clin Exp Immunol 101(Suppl 1):18–22PubMedPubMedCentralCrossRef Jennette JC, Falk RJ (1995) Clinical and pathological classification of ANCA-associated vasculitis: what are the controversies? Clin Exp Immunol 101(Suppl 1):18–22PubMedPubMedCentralCrossRef
92.
Zurück zum Zitat Kubaisi B, Abu Samra K, Foster CS (2016) Granulomatosis with polyangiitis (Wegener's disease): an updated review of ocular disease manifestations. Intractable Rare Dis Res 5:61–69PubMedPubMedCentralCrossRef Kubaisi B, Abu Samra K, Foster CS (2016) Granulomatosis with polyangiitis (Wegener's disease): an updated review of ocular disease manifestations. Intractable Rare Dis Res 5:61–69PubMedPubMedCentralCrossRef
93.
Zurück zum Zitat Comarmond C, Cacoub P (2014) Granulomatosis with polyangiitis (Wegener): clinical aspects and treatment. Autoimmun Rev 13:1121–1125PubMedCrossRef Comarmond C, Cacoub P (2014) Granulomatosis with polyangiitis (Wegener): clinical aspects and treatment. Autoimmun Rev 13:1121–1125PubMedCrossRef
94.
Zurück zum Zitat De Groot K, Rasmussen N, Bacon PA et al (2005) Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 52:2461–2469PubMedCrossRef De Groot K, Rasmussen N, Bacon PA et al (2005) Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 52:2461–2469PubMedCrossRef
95.
Zurück zum Zitat Flossmann O, Jones RB, Jayne DR, Luqmani RA (2006) Should rituximab be used to treat antineutrophil cytoplasmic antibody associated vasculitis? Ann Rheum Dis 65:841–844PubMedPubMedCentralCrossRef Flossmann O, Jones RB, Jayne DR, Luqmani RA (2006) Should rituximab be used to treat antineutrophil cytoplasmic antibody associated vasculitis? Ann Rheum Dis 65:841–844PubMedPubMedCentralCrossRef
96.
Zurück zum Zitat Jones RB, Tervaert JW, Hauser T et al (2010) Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. N Engl J Med 363:211–220PubMedCrossRef Jones RB, Tervaert JW, Hauser T et al (2010) Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. N Engl J Med 363:211–220PubMedCrossRef
97.
98.
Zurück zum Zitat Seo P, Specks U, Keogh KA (2008) Efficacy of rituximab in limited Wegener's granulomatosis with refractory granulomatous manifestations. J Rheumatol 35:2017–2023PubMed Seo P, Specks U, Keogh KA (2008) Efficacy of rituximab in limited Wegener's granulomatosis with refractory granulomatous manifestations. J Rheumatol 35:2017–2023PubMed
99.
Zurück zum Zitat Aries PM, Hellmich B, Voswinkel J et al (2006) Lack of efficacy of rituximab in Wegener's granulomatosis with refractory granulomatous manifestations. Ann Rheum Dis 65:853–858PubMedPubMedCentralCrossRef Aries PM, Hellmich B, Voswinkel J et al (2006) Lack of efficacy of rituximab in Wegener's granulomatosis with refractory granulomatous manifestations. Ann Rheum Dis 65:853–858PubMedPubMedCentralCrossRef
100.
Zurück zum Zitat Holle JU, Dubrau C, Herlyn K et al (2012) Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations. Ann Rheum Dis 71:327–333PubMedCrossRef Holle JU, Dubrau C, Herlyn K et al (2012) Rituximab for refractory granulomatosis with polyangiitis (Wegener's granulomatosis): comparison of efficacy in granulomatous versus vasculitic manifestations. Ann Rheum Dis 71:327–333PubMedCrossRef
101.
Zurück zum Zitat Khan A, Lawson CA, Quinn MA et al (2010) Successful treatment of ANCA-negative Wegener's granulomatosis with rituximab. Int J Rheumatol 2010:846063PubMedPubMedCentralCrossRef Khan A, Lawson CA, Quinn MA et al (2010) Successful treatment of ANCA-negative Wegener's granulomatosis with rituximab. Int J Rheumatol 2010:846063PubMedPubMedCentralCrossRef
102.
Zurück zum Zitat Martinez Del Pero M, Chaudhry A, Jones RB et al (2009) B cell depletion with rituximab for refractory head and neck Wegener's granulomatosis: a cohort studies. Clin Otolaryngol 34:328–335PubMedCrossRef Martinez Del Pero M, Chaudhry A, Jones RB et al (2009) B cell depletion with rituximab for refractory head and neck Wegener's granulomatosis: a cohort studies. Clin Otolaryngol 34:328–335PubMedCrossRef
103.
Zurück zum Zitat Ooka S, Maeda A, Ito H et al (2009) Treatment of refractory retrobulbar granuloma with rituximab in a patient with ANCA-negative Wegener's granulomatosis: a case report. Mod Rheumatol 19:80–83PubMedCrossRef Ooka S, Maeda A, Ito H et al (2009) Treatment of refractory retrobulbar granuloma with rituximab in a patient with ANCA-negative Wegener's granulomatosis: a case report. Mod Rheumatol 19:80–83PubMedCrossRef
104.
Zurück zum Zitat Shah S, Hruskova Z, Segelmark M et al (2015) Treatment of severe renal disease in ANCA positive and negative small vessel vasculitis with rituximab. Am J Nephrol 41(4–5):296–301PubMedCrossRef Shah S, Hruskova Z, Segelmark M et al (2015) Treatment of severe renal disease in ANCA positive and negative small vessel vasculitis with rituximab. Am J Nephrol 41(4–5):296–301PubMedCrossRef
105.
Zurück zum Zitat Charles P, Néel A, Tieulié N et al (2014) Rituximab for induction and maintenance treatment of ANCA-associated vasculitides: a multicentre retrospective study on 80 patients. Rheumatology (Oxford) 53:532–539CrossRef Charles P, Néel A, Tieulié N et al (2014) Rituximab for induction and maintenance treatment of ANCA-associated vasculitides: a multicentre retrospective study on 80 patients. Rheumatology (Oxford) 53:532–539CrossRef
106.
Zurück zum Zitat Mukhtyar C, Guillevin L, Cid MC et al (2009) EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis 68:310–317PubMedCrossRef Mukhtyar C, Guillevin L, Cid MC et al (2009) EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis 68:310–317PubMedCrossRef
107.
Zurück zum Zitat Samson M, Puéchal X, Devilliers H et al (2013) Long-term outcomes of 118 patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) enrolled in two prospective trials. J Autoimmun 43:60–69PubMedCrossRef Samson M, Puéchal X, Devilliers H et al (2013) Long-term outcomes of 118 patients with eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) enrolled in two prospective trials. J Autoimmun 43:60–69PubMedCrossRef
108.
Zurück zum Zitat Healy B, Bibby S, Steele R et al (2013) Antineutrophil cytoplasmic autoantibodies and myeloperoxidase autoantibodies in clinical expression of Churg-Strauss syndrome. J Allergy Clin Immunol 131:571–576PubMedCrossRef Healy B, Bibby S, Steele R et al (2013) Antineutrophil cytoplasmic autoantibodies and myeloperoxidase autoantibodies in clinical expression of Churg-Strauss syndrome. J Allergy Clin Immunol 131:571–576PubMedCrossRef
109.
Zurück zum Zitat Vaglio A, Strehl JD, Manger B et al (2012) IgG4 immune response in Churg-Strauss syndrome. Ann Rheum Dis 71:390–393PubMedCrossRef Vaglio A, Strehl JD, Manger B et al (2012) IgG4 immune response in Churg-Strauss syndrome. Ann Rheum Dis 71:390–393PubMedCrossRef
110.
Zurück zum Zitat Vaglio A, Moosig F, Zwerina J (2012) Churg-Strauss syndrome: update on pathophysiology and treatment. Curr Opin Rheumatol 24:24–30PubMedCrossRef Vaglio A, Moosig F, Zwerina J (2012) Churg-Strauss syndrome: update on pathophysiology and treatment. Curr Opin Rheumatol 24:24–30PubMedCrossRef
111.
Zurück zum Zitat Mohammad AJ, Hot A, Arndt F et al (2016) Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Ann Rheum Dis 75:396–401PubMedCrossRef Mohammad AJ, Hot A, Arndt F et al (2016) Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Ann Rheum Dis 75:396–401PubMedCrossRef
112.
Zurück zum Zitat Novikov P, Moiseev S, Smitienko I, Zagvozdkina E (2016) Rituximab as induction therapy in relapsing eosinophilic granulomatosis with polyangiitis: a report of 6 cases. Joint Bone Spine 83:81–84PubMedCrossRef Novikov P, Moiseev S, Smitienko I, Zagvozdkina E (2016) Rituximab as induction therapy in relapsing eosinophilic granulomatosis with polyangiitis: a report of 6 cases. Joint Bone Spine 83:81–84PubMedCrossRef
113.
Zurück zum Zitat Thiel J, Hässler F, Salzer U et al (2013) Rituximab in the treatment of refractory or relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Arthritis Res Ther 24(15):R133CrossRef Thiel J, Hässler F, Salzer U et al (2013) Rituximab in the treatment of refractory or relapsing eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome). Arthritis Res Ther 24(15):R133CrossRef
114.
Zurück zum Zitat Cartin-Ceba R, Keogh KA, Specks U et al (2011) Rituximab for the treatment of Churg–Strauss syndrome with renal involvement. Nephrol Dial Transplant 26:2865–2871PubMedPubMedCentralCrossRef Cartin-Ceba R, Keogh KA, Specks U et al (2011) Rituximab for the treatment of Churg–Strauss syndrome with renal involvement. Nephrol Dial Transplant 26:2865–2871PubMedPubMedCentralCrossRef
115.
Zurück zum Zitat Donvik KK, Omdal R (2011) Churg–Strauss syndrome successfully treated with rituximab. Rheumatol Int 31:89–91PubMedCrossRef Donvik KK, Omdal R (2011) Churg–Strauss syndrome successfully treated with rituximab. Rheumatol Int 31:89–91PubMedCrossRef
116.
Zurück zum Zitat Pepper RJ, Fabre MA, Pavesio C et al (2008) Rituximab is effective in the treatment of refractory Churg–Strauss syndrome and is associated with diminished T-cell interleukin-5 production. Rheumatology (Oxford) 47:1104–1105CrossRef Pepper RJ, Fabre MA, Pavesio C et al (2008) Rituximab is effective in the treatment of refractory Churg–Strauss syndrome and is associated with diminished T-cell interleukin-5 production. Rheumatology (Oxford) 47:1104–1105CrossRef
117.
Zurück zum Zitat Roccatello D, Sciascia S, Rossi D et al (2011) Long-term effects of rituximab added to cyclophosphamide in refractory patients with vasculitis. Am J Nephrol 34:175–180PubMedCrossRef Roccatello D, Sciascia S, Rossi D et al (2011) Long-term effects of rituximab added to cyclophosphamide in refractory patients with vasculitis. Am J Nephrol 34:175–180PubMedCrossRef
119.
Zurück zum Zitat Fanouriakis A, Kougkas N, Vassilopoulos D et al (2015) Rituximab for eosinophilic granulomatosis with polyangiitis with severe vasculitic neuropathy: case report and review of current clinical evidence. Semin Arthritis Rheum 45:60–66PubMedCrossRef Fanouriakis A, Kougkas N, Vassilopoulos D et al (2015) Rituximab for eosinophilic granulomatosis with polyangiitis with severe vasculitic neuropathy: case report and review of current clinical evidence. Semin Arthritis Rheum 45:60–66PubMedCrossRef
120.
Zurück zum Zitat Martinez-Villaescusa M, Lopez-Montes A, Lopez-Rubio E et al (2013) Treatment-resistant Churg–Strauss syndrome: progression after five years using rituximab. Nefrologia 33:737–739PubMed Martinez-Villaescusa M, Lopez-Montes A, Lopez-Rubio E et al (2013) Treatment-resistant Churg–Strauss syndrome: progression after five years using rituximab. Nefrologia 33:737–739PubMed
121.
Zurück zum Zitat Saech J, Owczarczyk K, Rosgen S et al (2009) Successful use of rituximab in a patient with Churg–Strauss syndrome and refractory central nervous system involvement. Ann Rheum Dis 69:1254–1255PubMed Saech J, Owczarczyk K, Rosgen S et al (2009) Successful use of rituximab in a patient with Churg–Strauss syndrome and refractory central nervous system involvement. Ann Rheum Dis 69:1254–1255PubMed
122.
Zurück zum Zitat Rees F, Yazdani R, Lanyon P (2011) Long-term follow-up of different refractory systemic vasculitides treated with rituximab. Clin Rheumatol 30:1241–1245PubMedCrossRef Rees F, Yazdani R, Lanyon P (2011) Long-term follow-up of different refractory systemic vasculitides treated with rituximab. Clin Rheumatol 30:1241–1245PubMedCrossRef
123.
Zurück zum Zitat Lovric S, Erdbruegger U, Kumpers P et al (2009) Rituximab as rescue therapy in anti-neutrophil cytoplasmic antibody-associated vasculitis: a single-centre experience with 15 patients. Nephrol Dial Transplant 24:179–185PubMedCrossRef Lovric S, Erdbruegger U, Kumpers P et al (2009) Rituximab as rescue therapy in anti-neutrophil cytoplasmic antibody-associated vasculitis: a single-centre experience with 15 patients. Nephrol Dial Transplant 24:179–185PubMedCrossRef
124.
Zurück zum Zitat Najem CE, Yadav R, Carlson E (2015) Successful use of rituximab in a patient with recalcitrant multisystemic eosinophilic granulomatosis with polyangiitis. BMJ Case Rep 15:2015 Najem CE, Yadav R, Carlson E (2015) Successful use of rituximab in a patient with recalcitrant multisystemic eosinophilic granulomatosis with polyangiitis. BMJ Case Rep 15:2015
125.
Zurück zum Zitat Diamanti L, Berzero G, Bini P et al (2014) Spinal hemorrhage in eosinophilic granulomatosis with polyangiitis (Churg–Strauss). J Neurol 261:438–440PubMedCrossRef Diamanti L, Berzero G, Bini P et al (2014) Spinal hemorrhage in eosinophilic granulomatosis with polyangiitis (Churg–Strauss). J Neurol 261:438–440PubMedCrossRef
126.
Zurück zum Zitat Chao MP, Hong J, Kunder C et al (2015) Refractory warm IgM-mediated autoimmune hemolytic anemia associated with Churg–Strauss syndrome responsive to eculizumab and rituximab. Am J Hematol 90:78–81PubMedCrossRef Chao MP, Hong J, Kunder C et al (2015) Refractory warm IgM-mediated autoimmune hemolytic anemia associated with Churg–Strauss syndrome responsive to eculizumab and rituximab. Am J Hematol 90:78–81PubMedCrossRef
127.
Zurück zum Zitat Grigoriou A, Endean A, Sangle SR, DP D′C (2014) B cell depletion therapy and eosinophilic granulomatosis with polyangiitis with hepatic involvement. Rheumatology (Oxford) 53:1741CrossRef Grigoriou A, Endean A, Sangle SR, DP D′C (2014) B cell depletion therapy and eosinophilic granulomatosis with polyangiitis with hepatic involvement. Rheumatology (Oxford) 53:1741CrossRef
128.
Zurück zum Zitat Umezawa N, Kohsaka H, Nanki T et al (2014) Successful treatment of eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg–Strauss syndrome) with rituximab in a case refractory to glucocorticoids, cyclophosphamide, and IVIG. Mod Rheumatol 24:685–687PubMedCrossRef Umezawa N, Kohsaka H, Nanki T et al (2014) Successful treatment of eosinophilic granulomatosis with polyangiitis (EGPA; formerly Churg–Strauss syndrome) with rituximab in a case refractory to glucocorticoids, cyclophosphamide, and IVIG. Mod Rheumatol 24:685–687PubMedCrossRef
129.
Zurück zum Zitat Smith KG, Jones RB, Burns SM, Jayne DR (2006) Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: remission, relapse, and re-treatment. Arthritis Rheum 54:2970–2982PubMedCrossRef Smith KG, Jones RB, Burns SM, Jayne DR (2006) Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: remission, relapse, and re-treatment. Arthritis Rheum 54:2970–2982PubMedCrossRef
130.
Zurück zum Zitat Kaushik VV, Reddy HV, Bucknall RC (2006) Successful use of rituximab in a patient with recalcitrant Churg–Strauss syndrome. Ann Rheum Dis 65:1116–1117PubMedPubMedCentralCrossRef Kaushik VV, Reddy HV, Bucknall RC (2006) Successful use of rituximab in a patient with recalcitrant Churg–Strauss syndrome. Ann Rheum Dis 65:1116–1117PubMedPubMedCentralCrossRef
131.
Zurück zum Zitat Baikunje S, Vankalakunti M, Upadhyaya VS, Hosmane GB (2016) Eosinophilic granulomatosis with polyangiitis with severe pulmonary hemorrhage treated with rituximab. Indian J Nephrol 26:142–144PubMedPubMedCentralCrossRef Baikunje S, Vankalakunti M, Upadhyaya VS, Hosmane GB (2016) Eosinophilic granulomatosis with polyangiitis with severe pulmonary hemorrhage treated with rituximab. Indian J Nephrol 26:142–144PubMedPubMedCentralCrossRef
132.
Zurück zum Zitat Groh M, Pagnoux C, Baldini C et al (2015) Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management. Eur J Intern Med 26:545–553PubMedCrossRef Groh M, Pagnoux C, Baldini C et al (2015) Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (EGPA) Consensus Task Force recommendations for evaluation and management. Eur J Intern Med 26:545–553PubMedCrossRef
133.
Zurück zum Zitat Jennette J, Falk R, Bacon P et al (2013) 2012 revised International Chapel Hill Consensus Conference Nomenclature of vasculitides. Arthritis Rheum 65:1–11PubMedCrossRef Jennette J, Falk R, Bacon P et al (2013) 2012 revised International Chapel Hill Consensus Conference Nomenclature of vasculitides. Arthritis Rheum 65:1–11PubMedCrossRef
134.
Zurück zum Zitat Ribi C, Cohen P, Pagnoux C et al (2010) Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: a prospective randomized study of one hundred twenty-four patients. Arthritis Rheum 62:1186–1197PubMedCrossRef Ribi C, Cohen P, Pagnoux C et al (2010) Treatment of polyarteritis nodosa and microscopic polyangiitis without poor-prognosis factors: a prospective randomized study of one hundred twenty-four patients. Arthritis Rheum 62:1186–1197PubMedCrossRef
135.
Zurück zum Zitat Gayraud M, Guillevin L, le Toumelin P et al (2001) Long-term follow-up of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: analysis of four prospective trials including 278 patients. Arthritis Rheum 44:666–675PubMedCrossRef Gayraud M, Guillevin L, le Toumelin P et al (2001) Long-term follow-up of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: analysis of four prospective trials including 278 patients. Arthritis Rheum 44:666–675PubMedCrossRef
136.
Zurück zum Zitat Pagnoux C, Seror R, Henegar C et al (2010) Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database. Arthritis Rheum 62:616–626PubMedCrossRef Pagnoux C, Seror R, Henegar C et al (2010) Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database. Arthritis Rheum 62:616–626PubMedCrossRef
137.
Zurück zum Zitat Da Silva LS, De Campos KV, de Melo AK et al (2015) Rituximab as an alternative for patients with severe systemic vasculitis refractory to conventional therapy: report of seven cases and literature review. Rev Bras Reumatol 55:531–535PubMedCrossRef Da Silva LS, De Campos KV, de Melo AK et al (2015) Rituximab as an alternative for patients with severe systemic vasculitis refractory to conventional therapy: report of seven cases and literature review. Rev Bras Reumatol 55:531–535PubMedCrossRef
138.
Zurück zum Zitat Seri Y, Shoda H, Hanata N et al (2015) A case of refractory polyarteritis nodosa successfully treated with rituximab. Mod Rheumatol 12:1–3 Seri Y, Shoda H, Hanata N et al (2015) A case of refractory polyarteritis nodosa successfully treated with rituximab. Mod Rheumatol 12:1–3
139.
Zurück zum Zitat Krishnan S, Bhakuni DS, Kartik S (2012) Rituximab in refractory cutaneous polyarteritis. Int J Rheum Dis 15:e127PubMedCrossRef Krishnan S, Bhakuni DS, Kartik S (2012) Rituximab in refractory cutaneous polyarteritis. Int J Rheum Dis 15:e127PubMedCrossRef
140.
Zurück zum Zitat Néel A, Masseau A, Hervier B et al (2011) Life-threatening hepatitis C virus-associated polyarteritis nodosa successfully treated by rituximab. J Clin Rheumatol 17:439–441PubMedCrossRef Néel A, Masseau A, Hervier B et al (2011) Life-threatening hepatitis C virus-associated polyarteritis nodosa successfully treated by rituximab. J Clin Rheumatol 17:439–441PubMedCrossRef
141.
142.
Zurück zum Zitat Ribeiro E, Cressend T, Duffau P et al (2009) Rituximab efficacy during a refractory polyarteritis nodosa flare. Case Rep Med 2009:738293PubMedCrossRef Ribeiro E, Cressend T, Duffau P et al (2009) Rituximab efficacy during a refractory polyarteritis nodosa flare. Case Rep Med 2009:738293PubMedCrossRef
143.
Zurück zum Zitat Eleftheriou D, Melo M, Marks SD et al (2009) Biologic therapy in primary systemic vasculitis of the young. Rheumatology (Oxford) 48:978–986CrossRef Eleftheriou D, Melo M, Marks SD et al (2009) Biologic therapy in primary systemic vasculitis of the young. Rheumatology (Oxford) 48:978–986CrossRef
144.
Zurück zum Zitat Zoshima T, Matsumura M, Suzuki Y et al (2013) A case of refractory cutaneous polyarteritis nodosa in a patient with hepatitis B carrier status successfully treated with tumor necrosis factor alpha blockade. Mod Rheumatol 23:1029–1033PubMedCrossRef Zoshima T, Matsumura M, Suzuki Y et al (2013) A case of refractory cutaneous polyarteritis nodosa in a patient with hepatitis B carrier status successfully treated with tumor necrosis factor alpha blockade. Mod Rheumatol 23:1029–1033PubMedCrossRef
145.
Zurück zum Zitat Feinstein J, Arroyo R (2005) Successful treatment of childhood onset refractory polyarteritis nodosa with tumor necrosis factor alpha blockade. J Clin Rheumatol 11:219–222PubMedCrossRef Feinstein J, Arroyo R (2005) Successful treatment of childhood onset refractory polyarteritis nodosa with tumor necrosis factor alpha blockade. J Clin Rheumatol 11:219–222PubMedCrossRef
146.
Zurück zum Zitat Tous-Romero F, Rodríguez-Almaraz E, Rodríguez-Peralto JL, Postigo-Llorente C (2017) Polyarteritis nodosa with a systemic inflammatory response pattern: effectiveness of anti-TNF. Actas Dermosifiliogr Tous-Romero F, Rodríguez-Almaraz E, Rodríguez-Peralto JL, Postigo-Llorente C (2017) Polyarteritis nodosa with a systemic inflammatory response pattern: effectiveness of anti-TNF. Actas Dermosifiliogr
147.
Zurück zum Zitat Valor L, Monteagudo I, de la Torre I et al (2014) Young male patient diagnosed with cutaneous polyarteritis nodosa successfully treated with etanercept. Mod Rheumatol 24:(4)688–689PubMedCrossRef Valor L, Monteagudo I, de la Torre I et al (2014) Young male patient diagnosed with cutaneous polyarteritis nodosa successfully treated with etanercept. Mod Rheumatol 24:(4)688–689PubMedCrossRef
148.
149.
Zurück zum Zitat Matsuo S, Hayashi K, Morimoto E et al (2017) The successful treatment of refractory polyarteritis nodosa using infliximab. Intern Med 56:1435–1438PubMedPubMedCentralCrossRef Matsuo S, Hayashi K, Morimoto E et al (2017) The successful treatment of refractory polyarteritis nodosa using infliximab. Intern Med 56:1435–1438PubMedPubMedCentralCrossRef
150.
Zurück zum Zitat Garcia-Porrua C, Gonzalez-Gay MA (2003) Successful response to infliximab in a patient with undifferentiated spondyloarthropathy coexisting with polyarteritis nodosa-like cutaneous vasculitis. Clin Exp Rheumatol 21(6 Suppl 32):S138PubMed Garcia-Porrua C, Gonzalez-Gay MA (2003) Successful response to infliximab in a patient with undifferentiated spondyloarthropathy coexisting with polyarteritis nodosa-like cutaneous vasculitis. Clin Exp Rheumatol 21(6 Suppl 32):S138PubMed
151.
Zurück zum Zitat Wu K, Throssell D (2006) A new treatment for polyarteritis nodosa. Nephrol Dial Transplant 21:1710–1712PubMedCrossRef Wu K, Throssell D (2006) A new treatment for polyarteritis nodosa. Nephrol Dial Transplant 21:1710–1712PubMedCrossRef
152.
Zurück zum Zitat Al-Bishri J, le Riche N, Pope JE (2005) Refractory polyarteritis nodosa successfully treated with infliximab. J Rheumatol 32:1371–1373PubMed Al-Bishri J, le Riche N, Pope JE (2005) Refractory polyarteritis nodosa successfully treated with infliximab. J Rheumatol 32:1371–1373PubMed
153.
Zurück zum Zitat Keystone EC (2004) The utility of tumour necrosis factor blockade in orphan diseases. Ann Rheum Dis 63(Suppl 2):ii79–ii83PubMedPubMedCentral Keystone EC (2004) The utility of tumour necrosis factor blockade in orphan diseases. Ann Rheum Dis 63(Suppl 2):ii79–ii83PubMedPubMedCentral
154.
Zurück zum Zitat Vega Gutierrez J, Rodriguez Prieto MA, Garcia Ruiz JM (2007) Successful treatment of childhood cutaneous polyarteritis nodosa with infliximab. J Eur Acad Dermatol Venereol 21:570–571PubMed Vega Gutierrez J, Rodriguez Prieto MA, Garcia Ruiz JM (2007) Successful treatment of childhood cutaneous polyarteritis nodosa with infliximab. J Eur Acad Dermatol Venereol 21:570–571PubMed
155.
Zurück zum Zitat Campanilho-Marques R, Ramos F, Canhão H, Fonseca JE (2014) Remission induced by infliximab in a childhood polyarteritis nodosa refractory to conventional immunosuppression and rituximab. Joint Bone Spine 81:277–278PubMedCrossRef Campanilho-Marques R, Ramos F, Canhão H, Fonseca JE (2014) Remission induced by infliximab in a childhood polyarteritis nodosa refractory to conventional immunosuppression and rituximab. Joint Bone Spine 81:277–278PubMedCrossRef
156.
Zurück zum Zitat Wahezi DM, Gomes WA, Ilowite NT (2010) Cranial nerve involvement with juvenile polyarteritis nodosa: clinical manifestations and treatment. Pediatrics 126:e719–e722PubMedCrossRef Wahezi DM, Gomes WA, Ilowite NT (2010) Cranial nerve involvement with juvenile polyarteritis nodosa: clinical manifestations and treatment. Pediatrics 126:e719–e722PubMedCrossRef
157.
Zurück zum Zitat Braun-Moscovici Y, Markovits D, Rozin A et al (2008) Anti-tumor necrosis factor therapy: 6 year experience of a single center in northern Israel and possible impact of health policy on results. Isr Med Assoc J 10:277–281PubMed Braun-Moscovici Y, Markovits D, Rozin A et al (2008) Anti-tumor necrosis factor therapy: 6 year experience of a single center in northern Israel and possible impact of health policy on results. Isr Med Assoc J 10:277–281PubMed
158.
Zurück zum Zitat Soriano A, Pipitone N, Salvarani C Cardiac involvement in Behçet disease. In: The heart in rheumatic, autoimmune and inflammatory diseases. Elsevier Ed. ISBN: 978-0-12-803267-1 | Feb 28, 2017 Soriano A, Pipitone N, Salvarani C Cardiac involvement in Behçet disease. In: The heart in rheumatic, autoimmune and inflammatory diseases. Elsevier Ed. ISBN: 978-0-12-803267-1 | Feb 28, 2017
159.
Zurück zum Zitat Ombrello MJ, Kirino Y, de Bakker PI, Kastner DL, Remmers EF (2014) Behcet disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated toxicity. Proc Natl Acad Sci U S A 111(24):8867–8872PubMedPubMedCentralCrossRef Ombrello MJ, Kirino Y, de Bakker PI, Kastner DL, Remmers EF (2014) Behcet disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated toxicity. Proc Natl Acad Sci U S A 111(24):8867–8872PubMedPubMedCentralCrossRef
160.
161.
Zurück zum Zitat Mahr A, Belarbi L, Wechsler B et al (2008) Population-based prevalence study of Behcet's disease: differences by ethnic origin and low variation by age at immigration. Arthritis Rheum 58:3951–3959PubMedCrossRef Mahr A, Belarbi L, Wechsler B et al (2008) Population-based prevalence study of Behcet's disease: differences by ethnic origin and low variation by age at immigration. Arthritis Rheum 58:3951–3959PubMedCrossRef
162.
Zurück zum Zitat Salvarani C, Pipitone N, Catanoso MG et al (2007) Epidemiology and clinical course of Behcet's disease in the Reggio Emilia area of Northern Italy: a seventeen-year population-based study. Arthritis Rheum 57:171–178PubMedCrossRef Salvarani C, Pipitone N, Catanoso MG et al (2007) Epidemiology and clinical course of Behcet's disease in the Reggio Emilia area of Northern Italy: a seventeen-year population-based study. Arthritis Rheum 57:171–178PubMedCrossRef
163.
Zurück zum Zitat Calamia KT, Wilson FC, Icen M, Crowson CS, Gabriel SE, Kremers HM (2009) Epidemiology and clinical characteristics of Behcet's disease in the US: a population-based study. Arthritis Rheum 61:600–604PubMedPubMedCentralCrossRef Calamia KT, Wilson FC, Icen M, Crowson CS, Gabriel SE, Kremers HM (2009) Epidemiology and clinical characteristics of Behcet's disease in the US: a population-based study. Arthritis Rheum 61:600–604PubMedPubMedCentralCrossRef
164.
Zurück zum Zitat Zouboulis CC (1999) Epidemiology of Adamantiades-Behcet's disease. Ann Med Interne (Paris) 150:488–498 Zouboulis CC (1999) Epidemiology of Adamantiades-Behcet's disease. Ann Med Interne (Paris) 150:488–498
165.
Zurück zum Zitat Savey L, Resche-Rigon M, Wechsler B et al (2014) Ethnicity and association with disease manifestations and mortality in Behcet's disease. Orphanet J Rare Dis 9:42PubMedPubMedCentralCrossRef Savey L, Resche-Rigon M, Wechsler B et al (2014) Ethnicity and association with disease manifestations and mortality in Behcet's disease. Orphanet J Rare Dis 9:42PubMedPubMedCentralCrossRef
166.
Zurück zum Zitat Behcet H (1937) Über rezidivierende, aphthöse, durch ein virus verursachte Geschwüre am Mund, am Auge und an den Genitalien. Dermatol Wochenschr 105:1152–1157 Behcet H (1937) Über rezidivierende, aphthöse, durch ein virus verursachte Geschwüre am Mund, am Auge und an den Genitalien. Dermatol Wochenschr 105:1152–1157
167.
Zurück zum Zitat Davatchi F, Sadeghi AB, Chams-Davatchi C et al (2015) The saga of diagnostic/classification criteria in Behcet's disease. Int J Rheum Dis 18:594–605PubMedCrossRef Davatchi F, Sadeghi AB, Chams-Davatchi C et al (2015) The saga of diagnostic/classification criteria in Behcet's disease. Int J Rheum Dis 18:594–605PubMedCrossRef
168.
Zurück zum Zitat Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's Disease. Lancet 1990; 335:1078–80 Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's Disease. Lancet 1990; 335:1078–80
169.
Zurück zum Zitat O'Neill TW, Rigby AS, Silman AJ, Barnes C (1994) Validation of the International Study Group criteria for Behcet's disease. Br J Rheumatol 33:115–117PubMedCrossRef O'Neill TW, Rigby AS, Silman AJ, Barnes C (1994) Validation of the International Study Group criteria for Behcet's disease. Br J Rheumatol 33:115–117PubMedCrossRef
170.
Zurück zum Zitat Yazici H, Yazici Y (2014) Criteria for Behçet’s disease with reflections on all disease criteria. J Autoimmun 48-49:104–107PubMedCrossRef Yazici H, Yazici Y (2014) Criteria for Behçet’s disease with reflections on all disease criteria. J Autoimmun 48-49:104–107PubMedCrossRef
171.
Zurück zum Zitat The International Criteria for Behcet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol 2014; 28:338–47 The International Criteria for Behcet's Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol 2014; 28:338–47
172.
Zurück zum Zitat Ozguler Y, Leccese P, Christensen R et al (2016) A systematic literature review on the treatment of major organ involvement of Behçet’s syndrome informing the EULAR recommendations for the management of Behçet’s syndrome. Clin Exp Rheumatol 34(Suppl. 102):S175 Ozguler Y, Leccese P, Christensen R et al (2016) A systematic literature review on the treatment of major organ involvement of Behçet’s syndrome informing the EULAR recommendations for the management of Behçet’s syndrome. Clin Exp Rheumatol 34(Suppl. 102):S175
173.
Zurück zum Zitat Guzelant G, Ucar D, Hatemi G et al (2016) Earlier use of infliximab for the uveitis of Behçet’s syndrome appears to be associated with better outcome. Clin Exp Rheumatol 34(Suppl. 102):S143 Guzelant G, Ucar D, Hatemi G et al (2016) Earlier use of infliximab for the uveitis of Behçet’s syndrome appears to be associated with better outcome. Clin Exp Rheumatol 34(Suppl. 102):S143
174.
Zurück zum Zitat Esatoglu SN, Hatemi G, Leccese P (2016) Olivieri I. Highlights of the 17th International Conference on Behçet’s syndrome. Matera, Italy, 15-17 September 2016. Clin Exp Rheumatol 34(Suppl 012):S3–S9 Esatoglu SN, Hatemi G, Leccese P (2016) Olivieri I. Highlights of the 17th International Conference on Behçet’s syndrome. Matera, Italy, 15-17 September 2016. Clin Exp Rheumatol 34(Suppl 012):S3–S9
175.
Zurück zum Zitat Lopalco G, Emmi G, Gentileschi S et al (2016) Certolizumab pegol treatment in Behçet’s disease: a multicenter retrospective observational study. Clin Exp Rheumatol 34(Suppl. 102):S187 Lopalco G, Emmi G, Gentileschi S et al (2016) Certolizumab pegol treatment in Behçet’s disease: a multicenter retrospective observational study. Clin Exp Rheumatol 34(Suppl. 102):S187
176.
Zurück zum Zitat Tsianakas A, Brunner PM, Ghoreschi K et al (2016) The single-chain anti-TNF antibody DLX105 induces clinical and biomarkers responses upon local administration in patients with chronic plaque-type psoriasis. Exp Dermatol 25:428–433PubMedCrossRef Tsianakas A, Brunner PM, Ghoreschi K et al (2016) The single-chain anti-TNF antibody DLX105 induces clinical and biomarkers responses upon local administration in patients with chronic plaque-type psoriasis. Exp Dermatol 25:428–433PubMedCrossRef
177.
Zurück zum Zitat Xenitidis T, Berger C, Jung T, Henes J, Koetter I (2016) Effective and rapid treatment of flares in patients with Behçet’s disease by the single chain anti-TNF antibody DLX105. Clin Exp Rheumatol 34(Suppl. 102):S188 Xenitidis T, Berger C, Jung T, Henes J, Koetter I (2016) Effective and rapid treatment of flares in patients with Behçet’s disease by the single chain anti-TNF antibody DLX105. Clin Exp Rheumatol 34(Suppl. 102):S188
178.
Zurück zum Zitat Hatemi G, Melikoglu M, Tunc R et al (2015) Apremilast for Behçet’s syndrome—a phase 2, placebo-controlled study. N Engl J Med 372:1510–1518PubMedCrossRef Hatemi G, Melikoglu M, Tunc R et al (2015) Apremilast for Behçet’s syndrome—a phase 2, placebo-controlled study. N Engl J Med 372:1510–1518PubMedCrossRef
179.
Zurück zum Zitat Touzot M, Cacoub P, Bodaghi B, Soumelis V, Saadoun D (2015) IFN-a induces IL-10 production and tilt the balance between Th1 and Th17 in Behçet disease. Autoimmun Rev 14:370e375CrossRef Touzot M, Cacoub P, Bodaghi B, Soumelis V, Saadoun D (2015) IFN-a induces IL-10 production and tilt the balance between Th1 and Th17 in Behçet disease. Autoimmun Rev 14:370e375CrossRef
180.
Zurück zum Zitat Habibagahi Z, Habibagahi M, Heidari M (2010) Raised concentration of soluble form of vascular endothelial cadherin and IL-23 in sera of patients with Behçet's disease. Mod Rheumatol 20:154e159CrossRef Habibagahi Z, Habibagahi M, Heidari M (2010) Raised concentration of soluble form of vascular endothelial cadherin and IL-23 in sera of patients with Behçet's disease. Mod Rheumatol 20:154e159CrossRef
181.
Zurück zum Zitat Mirouse A, Barete S, Monfort JB et al (2017) Ustekinumab for Behçet’s disease. J Autoimmun 82:41–46PubMedCrossRef Mirouse A, Barete S, Monfort JB et al (2017) Ustekinumab for Behçet’s disease. J Autoimmun 82:41–46PubMedCrossRef
182.
Zurück zum Zitat Cantarini L, Vitale A, Scalini P, Dinarello CA, Rigante D, Franceschini R, Simonini G et al (2015) Anakinra treatment in drug-resistant Behcet’s disease: a case series. Clin Rheumatol 34:1293–1301PubMedCrossRef Cantarini L, Vitale A, Scalini P, Dinarello CA, Rigante D, Franceschini R, Simonini G et al (2015) Anakinra treatment in drug-resistant Behcet’s disease: a case series. Clin Rheumatol 34:1293–1301PubMedCrossRef
183.
Zurück zum Zitat Botsios C, Sfriso P, Furlan A, Punzi L, Dinarello CA (2008) Resistant Behçet disease responsive to anakinra. Ann Intern Med 149:284–286PubMedCrossRef Botsios C, Sfriso P, Furlan A, Punzi L, Dinarello CA (2008) Resistant Behçet disease responsive to anakinra. Ann Intern Med 149:284–286PubMedCrossRef
184.
Zurück zum Zitat Vitale A, Rigante D, Caso F et al (2014) Inhibition of interleukin-1 by canakinumab as a successful mono-drug strategy for the treatment of refractory Behçet’s disease: a case series. Dermatology 228:211–214PubMedCrossRef Vitale A, Rigante D, Caso F et al (2014) Inhibition of interleukin-1 by canakinumab as a successful mono-drug strategy for the treatment of refractory Behçet’s disease: a case series. Dermatology 228:211–214PubMedCrossRef
185.
Zurück zum Zitat Capittini C, De Silvestri C, De Silvestri A, Scotti V, Scudelleri L, Tinelli C (2016) Systematic review of the literature for the use of intravenous immunoglobulins in Behçet disease. Clin Exp Rheumatol 34(Suppl. 102):S182 Capittini C, De Silvestri C, De Silvestri A, Scotti V, Scudelleri L, Tinelli C (2016) Systematic review of the literature for the use of intravenous immunoglobulins in Behçet disease. Clin Exp Rheumatol 34(Suppl. 102):S182
186.
Zurück zum Zitat Capittini C, De Amici M, De Silvestri A (2016) Plasma cytokines as biomarkers for clinical response during nine months of intravenous immunoglobulins therapy in a Behçet disease patient unsuitable for immunosuppression. Clin Exp Rheumatol 34(Suppl. 102):S182 Capittini C, De Amici M, De Silvestri A (2016) Plasma cytokines as biomarkers for clinical response during nine months of intravenous immunoglobulins therapy in a Behçet disease patient unsuitable for immunosuppression. Clin Exp Rheumatol 34(Suppl. 102):S182
187.
Zurück zum Zitat Shapiro LS, Farrell J, Borhani HA (2012) Tocilizumab treatment for neuro-Behcet’s disease, the first report. Clin Neurol Neurosurg 114:297–298PubMedCrossRef Shapiro LS, Farrell J, Borhani HA (2012) Tocilizumab treatment for neuro-Behcet’s disease, the first report. Clin Neurol Neurosurg 114:297–298PubMedCrossRef
188.
Zurück zum Zitat Addimanda O, Pipitone N, Pazzola G, Salvarani C (2015) Tocilizumab for severe refractory neuro-Behçet: three cases IL-6 blockade in neuro-Behçet. Semin Arthritis Rheum 44:472–475PubMedCrossRef Addimanda O, Pipitone N, Pazzola G, Salvarani C (2015) Tocilizumab for severe refractory neuro-Behçet: three cases IL-6 blockade in neuro-Behçet. Semin Arthritis Rheum 44:472–475PubMedCrossRef
Metadaten
Titel
Unmet Needs in the Pathogenesis and Treatment of Vasculitides
verfasst von
Francesco Muratore
Giulia Pazzola
Alessandra Soriano
Nicolò Pipitone
Stefania Croci
Martina Bonacini
Luigi Boiardi
Carlo Salvarani
Publikationsdatum
11.09.2017
Verlag
Springer US
Erschienen in
Clinical Reviews in Allergy & Immunology / Ausgabe 2/2018
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-017-8643-2

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