Skip to main content
main-content

01.02.2013 | Viewpoint | Ausgabe 1/2013

Breast Cancer Research 1/2013

Unraveling the 'TGF-β paradox' one metastamir at a time

Zeitschrift:
Breast Cancer Research > Ausgabe 1/2013
Autoren:
Danny R Welch, Douglas R Hurst
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Abstract

Transforming growth factor beta (TGF-β) has received noteworthy attention in the recent past due to its unique characteristic of functionally switching roles from tumor suppressor to metastasis promoter. To uncover the black box surrounding the mechanisms of TGF-β, Taylor and colleagues performed global miRNA expression analyses using a murine mammary carcinoma progression model. They discovered multiple miRNA regulated by TGF-β and matrix stiffness. Focusing on miR-181a, they uncovered an intricate pathway regulating breast cancer metastasis that sheds new insight into metastasis regulation that may prove useful in clinical settings.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2013

Breast Cancer Research 1/2013 Zur Ausgabe

Neu im Fachgebiet Onkologie

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Onkologie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise